Patents by Inventor Sharath K. Rai
Sharath K. Rai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240000913Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.Type: ApplicationFiled: May 16, 2023Publication date: January 4, 2024Inventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
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Patent number: 11701415Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.Type: GrantFiled: February 16, 2021Date of Patent: July 18, 2023Assignee: Zoetis Services LLCInventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
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Publication number: 20230100089Abstract: The invention provides a substantially antigen-free composition for induction of innate immune response in a bird or a mammal, the composition comprising a saponin, a sterol, a quaternary amine, and a polyacrylic polymer to the mammal or bird. Methods of using the composition are also provided.Type: ApplicationFiled: April 28, 2022Publication date: March 30, 2023Inventors: Paul Joseph Dominowski, Duncan Mwangi, Joseph M. Bricker, Dennis L. Foss, Sharath K. Rai, Suman Mahan
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Patent number: 11318200Abstract: The invention provides a substantially antigen-free composition for induction of innate immune response in a bird or a mammal, the composition comprising a saponin, a sterol, a quaternary amine, and a polyacrylic polymer to the mammal or bird. Methods of using the composition are also provided.Type: GrantFiled: November 21, 2014Date of Patent: May 3, 2022Assignee: Zoetis Services LLCInventors: Paul Joseph Dominowski, Duncan Mwangi, Joseph M. Bricker, Dennis L. Foss, Sharath K. Rai, Suman Mahan
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Publication number: 20220047696Abstract: The invention provides stable coronavirus spike proteins. Immunogenic compositions comprising same and the methods of using these immunogenic compositions are also provided.Type: ApplicationFiled: July 30, 2021Publication date: February 17, 2022Inventors: Eric Todd Baima, Yulia Burakova, Paul Joseph Dominowski, Steven Alan Dunham, Nicole Lynn Hainer, John Morgan Hardham, Mahesh Kumar, Jason John Millership, Duncan M. Mwangi, Sharath K. Rai, Sharon Marie Wappel, Dennis Lee Foss
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Publication number: 20210170013Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.Type: ApplicationFiled: February 16, 2021Publication date: June 10, 2021Inventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
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Patent number: 10953080Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.Type: GrantFiled: October 22, 2018Date of Patent: March 23, 2021Assignee: Zoetis Services LLCInventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
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Publication number: 20210008195Abstract: Disclosed is a method of protecting an animal in need thereof from Hendra or Nipah virus infection comprising administering to said animal a single dose of a vaccine, the vaccine comprising:an antigen component comprising a Hendra antigen or a Nipah antigen; and an adjuvant comprising oil, polycationic carrier and a CpG containing immunostimulatory oligonucleotide, wherein the vaccine is a W/O emulsion.Type: ApplicationFiled: December 18, 2018Publication date: January 14, 2021Inventors: Paul Joseph Dominowski, Duncan M. Mwangi, Dennis Lee Foss, Sharath K. Rai, John Morgan Hardham
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Patent number: 10456459Abstract: The invention provides a liposomal adjuvant composition comprising an external membrane and an internal compartment, the external membrane comprising: a quaternary ammonium compound; a sterol; a phospholipid; and a glycolipid. Vaccine compositions comprising the liposomal adjuvant of the instant invention are also provided.Type: GrantFiled: July 19, 2016Date of Patent: October 29, 2019Assignee: Zoetis Services LLCInventors: Paul Joseph Dominowski, Duncan Mwangi, Sharath K. Rai, Dennis L. Foss, Traci K. Godbee, Laurel Mary Sly, Suman Mahan, Shaunak Vora
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Publication number: 20190038737Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.Type: ApplicationFiled: October 22, 2018Publication date: February 7, 2019Inventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
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Patent number: 10117921Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.Type: GrantFiled: September 19, 2014Date of Patent: November 6, 2018Assignee: Zoetis Services LLCInventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
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Publication number: 20180021424Abstract: The invention provides a liposomal adjuvant composition comprising an external membrane and an internal compartment, the external membrane comprising: a quaternary ammonium compound; a sterol; a phospholipid; and a glycolipid. Vaccine compositions comprising the liposomal adjuvant of the instant invention are also provided.Type: ApplicationFiled: July 19, 2016Publication date: January 25, 2018Inventors: Paul Joseph Dominowski, Duncan Mwangi, Sharath K. Rai, Dennis L. Foss, Traci K. Godbee, Laurel Mary Sly, Suman Mahan, Shaunak Vora
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Publication number: 20180008701Abstract: The invention provides a substantially antigen-free composition for induction of innate immune response in a bird or a mammal, the composition comprising a saponin, a sterol, a quaternary amine, and a polyacrylic polymer to the mammal or bird. Methods of using the composition are also provided.Type: ApplicationFiled: November 21, 2014Publication date: January 11, 2018Inventors: Paul Joseph Dominowski, Duncan Mwangi, Joseph Bricker, Dennis Foss, Sharath K. Rai, Suman Mahan
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Publication number: 20150140034Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.Type: ApplicationFiled: September 19, 2014Publication date: May 21, 2015Inventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
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Publication number: 20110020909Abstract: The present invention relates generally to the growth of Lawsonia intracellularis in non-mammalian cells and the production of the bacteria on a large scale.Type: ApplicationFiled: October 14, 2008Publication date: January 27, 2011Applicant: Pfizer Inc.Inventors: Jonathan Evans, Connie Gebhart, Michael John Huether, Rajendra Krishnan, Gregory P. Nitzel, Sharath K. Rai, Catherine J. Streitzel
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Publication number: 20030104357Abstract: The present invention demonstrates that JSRV envelope protein (Env) can be used to transduce human and other mammalian cells. Hybrid retrovirus packaging cells have been constructed that express the JSRV Env and retrovirus Gag-Pol proteins, and can produce JSRV-pseudotype vectors at high titers. Using high-titer virus the host range for JSRV has been established, and included sheep, human, monkey, bovine and dog cells, but not murine, rat or hamster cells. Retroviral packaging cell lines comprising the JSRV envelope protein, and receptor binding fragments thereof, are provided which transiently and stably produce high titers of recombinant retrovirus particles which can be used to transfer a heterologous gene to a eukaryotic cell.Type: ApplicationFiled: March 29, 2002Publication date: June 5, 2003Applicant: Fred Hutchinson Cancer Research CenterInventors: Sharath K. Rai, Arthur Dusty Miller