Patents by Inventor Sharmila Shankar

Sharmila Shankar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating cancer
    Patent number: 11286241
    Abstract: This invention is directed to compositions and methods for treating cancer in a patient.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: March 29, 2022
    Assignee: GLAX LLC
    Inventors: Rakesh K Srivastava, Sharmila Shankar, Sushant Kumar Shrivastava, Prabhash Nath Tripathi, Pavan Srivastava
  • Compositions and methods for reducing cell viability
    Patent number: 11208389
    Abstract: This invention is directed to compositions, methods and kits that can be used for reducing cell viability, inducing cell apoptosis, and inhibiting cell proliferation, such as for the treatment of cancer. The invention is also directed to compositions, methods and kits that can be used for treating inflammatory conditions, such as by modulating inflammatory cytokines.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: December 28, 2021
    Assignee: GLAX LLC
    Inventors: Rakesh K Srivastava, Sharmila Shankar, Sushant Kumar Shrivastava, Anupam G. Banerjee
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20200087267
    Abstract: This invention is directed to compositions and methods for treating cancer in a patient.
    Type: Application
    Filed: September 9, 2019
    Publication date: March 19, 2020
    Applicant: GLAX LLC
    Inventors: Rakesh K Srivastava, Sharmila Shankar, Sushant Kumar Shrivastava, Prabhash Nath Tripathi, Pavan Srivastava
  • METHODS FOR TREATING CANCER AND METABOLIC SYNDROME
    Publication number: 20190336486
    Abstract: This invention is directed to methods for treating cancer and metabolic syndrome.
    Type: Application
    Filed: April 30, 2019
    Publication date: November 7, 2019
    Applicant: GLAX LLC
    Inventors: Rakesh K Srivastava, Sharmila Shankar, Sushant Kumar Shrivastava, Pavan Srivastava, Piyoosh Sharma, Prabhash Nath Tripathi
  • COMPOSITIONS AND METHODS FOR REDUCING CELL VIABILITY
    Publication number: 20190330165
    Abstract: This invention is directed to compositions, methods and kits that can be used for reducing cell viability, inducing cell apoptosis, and inhibiting cell proliferation, such as for the treatment of cancer. The invention is also directed to compositions, methods and kits that can be used for treating inflammatory conditions, such as by modulating inflammatory cytokines.
    Type: Application
    Filed: April 29, 2019
    Publication date: October 31, 2019
    Applicant: GLAX LLC
    Inventors: Rakesh K Srivastava, Sharmila Shankar, Sushant Kumar Shrivastava, Anupam G. Banerjee
  • COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CANCER BY TARGETING AND INHIBITING CANCER STEM CELLS
    Publication number: 20130129809
    Abstract: The invention relates to compositions and methods for treating cancer comprising administering to a subject in need a pharmaceutically effective dose of a cancer stem cell inhibitor, methods of inhibiting the growth of cancer stem cells or tumor initiating cell comprising administering to a subject in need a pharmaceutically effective dose of a cancer stem cell inhibitor, and methods of enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells comprising administering to a subject in need a pharmaceutically effective dose of a chemotherapeutic drug and a pharmaceutically effective dose of a cancer stem cell inhibitor.
    Type: Application
    Filed: May 21, 2012
    Publication date: May 23, 2013
    Applicant: Glax L.L.C.
    Inventors: Rakesh K. Srivastava, Sharmila Shankar
  • METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS
    Publication number: 20110172234
    Abstract: This invention describes a series of methods and compositions for prevention and treatment of diseases such as cancer. One aspect of the invention describes small molecule-based drugs that can be used to bind to death receptors TRAIL-R1/DR4 and/or TRAIL-R2/DR5 and induce apoptosis in cancer cells, while sparing normal cells. The invention also describes TRAIL Death Receptor Agonists/Activators (DRAs) and their uses, such as the induction of apoptosis through caspase-8 and caspase-3 activation. The present invention also describes the methods of treating cancers, such as breast, prostate, colon, pancreatic, ovarian, lung, and brain cancers, leukemia, lymphoma, multiple myeloma, and mesothelioma, using DRAs either as single-agent treatments, or in combination with other therapies.
    Type: Application
    Filed: March 28, 2011
    Publication date: July 14, 2011
    Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, UNIVERSITY OF MARYLAND, BALTIMORE A CONSTITUENT INSTITUTION OF THE UNIVERSITY
    Inventors: Rakesh Srivastava, Sharmila Shankar, Alexander D. MacKerell, JR.
  • Methods and compositions of trail-death receptor agonists/activators
    Patent number: 7915245
    Abstract: This invention describes a series of methods and compositions for prevention and treatment of diseases such as cancer. One aspect of the invention describes small molecule-based drugs that can be used to bind to death receptors TRAIL-R1/DR4 and/or TRAIL-R2/DR5 and induce apoptosis in cancer cells, while sparing normal cells. The invention also describes TRAIL Death Receptor Agonists/Activators (DRAs) and their uses, such as the induction of apoptosis through caspase-8 and caspase-3 activation. The present invention also describes the methods of treating cancers, such as breast, prostate, colon, pancreatic, ovarian, lung, and brain cancers, leukemia, lymphoma, multiple myeloma, and mesothelioma, using DRAs either as single-agent treatments, or in combination with other therapies.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: March 29, 2011
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Rakesh Srivastava, Sharmila Shankar, Alexander D. Mackerell, Jr.
  • METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS
    Publication number: 20080214547
    Abstract: This invention describes a series of methods and compositions for prevention and treatment of diseases such as cancer. One aspect of the invention describes small molecule-based drugs that can be used to bind to death receptors TRAIL-R1/DR4 and/or TRAIL-R2/DR5 and induce apoptosis in cancer cells, while sparing normal cells. The invention also describes TRAIL Death Receptor Agonists/Activators (DRAs) and their uses, such as the induction of apoptosis through caspase-8 and caspase-3 activation. The present invention also describes the methods of treating cancers, such as breast, prostate, colon, pancreatic, ovarian, lung, and brain cancers, leukemia, lymphoma, multiple myeloma, and mesothelioma, using DRAs either as single-agent treatments, or in combination with other therapies.
    Type: Application
    Filed: October 2, 2007
    Publication date: September 4, 2008
    Inventors: Rakesh K. Srivastava, Sharmila Shankar