Patents by Inventor Sharon Boyd

Sharon Boyd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING CANCER WITH AN ANTIBODY-DRUG CONJUGATE
    Publication number: 20090175888
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: March 2, 2009
    Publication date: July 9, 2009
    Applicant: Medarex, Inc.
    Inventors: Howard P. Ng, Zhihong Li, Danny P.C. McGee, Oliver L. Saunders, Guoxian Wu, David J. King, Valeri Martichonok, Sharon Boyd, Thomas J. Lobl
  • Chemical linkers and conjugates thereof
    Publication number: 20060024317
    Abstract: The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
    Type: Application
    Filed: May 19, 2005
    Publication date: February 2, 2006
    Applicant: Medarex, Inc
    Inventors: Sharon Boyd, Liang Chen, Sanjeev Gangwar, Vincent Guerlavais, Killian Horgan, Zhi-Hong Li, Bilal Sufi
  • Disulfide prodrugs and linkers and stabilizers useful therefor
    Patent number: 6989452
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: January 24, 2006
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Zhihong Li, Danny P. C. McGee, Oliver L. Saunders, Guoxian Wu, David J. King, Valeri Martichonok, Sharon Boyd, Thomas J. Lobl
  • Disulfide prodrugs and linkers and stabilizers useful therefor
    Publication number: 20050272798
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: June 21, 2005
    Publication date: December 8, 2005
    Applicant: Medarex, Inc.
    Inventors: Howard Ng, Zhihong Li, Danny McGee, Oliver Saunders, Guoxian Wu, David King, Valeri Martichonok, Sharon Boyd, Thomas Lobl
  • Disulfide prodrugs and linkers and stabilizers useful therefor
    Publication number: 20030073852
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Application
    Filed: May 31, 2002
    Publication date: April 17, 2003
    Applicant: Medarex, Inc.
    Inventors: Howard P. Ng, Zhihong Li, Danny P.C. McGee, Oliver L. Saunders, Guoxian Wu, David J. King, Valeri Martichonok, Sharon Boyd, Thomas J. Lobl