Patents by Inventor Sharron Brown

Sharron Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tweak-pseudomonas exotoxin a fusion protein for cancer therapy
    Publication number: 20080175896
    Abstract: Soluble TNF superfamily ligand monomers, including TWEAK, spontaneously associate into a homotrimeric structure that binds with high affinity to a cell surface receptor(s). A TWEAK is fused with a modified (mutant) Pseudomonas exotoxin (PE38). This fusion protein's TWEAK domain binds with high affinity to a fibroblast growth factor-inducible 14 (Fn14) cell surface receptor. These fusion proteins act as cytotoxins targeting various cells, diseased cells, such as cancer cells, and cells undergoing cellular insult response.
    Type: Application
    Filed: November 30, 2007
    Publication date: July 24, 2008
    Inventors: Jeffrey A. Winkles, Sharron Brown