Patents by Inventor Shawn T. Blumberg

Shawn T. Blumberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recrystallized HI-6 dimethylsulfate
    Patent number: 11986779
    Abstract: The present invention is directed at the synthesis and characterization of recrystallized HI-6 dimethylsulfate (DMS). The method can comprise dissolving HI-6 DMS in an alkyl-based glycol and adding an antisolvent to recrystallize HI-6 DMS or dissolving HI-6 DMS in methanol and adding dimethoxy ethane or dimethyl formamide as the antisolvent to recrystallize HI-6 DMS. The recrystallized HI-6 DMS indicates a resistance to moisture absorption and/or a DSC melting point onset (MP Onset) at least at or above 160.0° C.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: May 21, 2024
    Assignee: SOUTHWEST RESEARCH INSTITUTE
    Inventors: Shawn T. Blumberg, Paul W. Miguel
  • ILLUDIN ANALOGS, USES THEREOF, AND METHODS FOR SYNTHESIZING THE SAME
    Publication number: 20230399285
    Abstract: This invention provides illudin derivatives, intermediates, preparation methods, pharmaceutical compositions and uses thereof. Specific examples include novel synthetic routes to prepare illudin derivatives and an illudin derivative having a positive optical rotation, which has therapeutic value.
    Type: Application
    Filed: August 27, 2023
    Publication date: December 14, 2023
    Applicant: LANTERN PHARMA INC.
    Inventors: Gregory J. Tobin, Shawn T. Blumberg, Andrey D. Malakhov
  • SYNTHETIC ROUTE TO SCOPOLAMINE AND/OR ATROPINE
    Publication number: 20230312555
    Abstract: A synthetic route to scopolamine and/or atropine. In such context, the present invention identifies a method for preparing 6,7-dehydro atropine, which can be converted into either scopolamine and/or atropine, along with a method for converting a protected pyrrole into a tetrachlorobicylic compound, such as benzyl 3-oxo-8-azabicyclo[3.2.1]oct-6-ene-8-carboxylate.
    Type: Application
    Filed: April 25, 2023
    Publication date: October 5, 2023
    Inventors: Shawn T. BLUMBERG, Paul W. MIGUEL, Daniel A. HINOJOSA
  • Synthetic route to scopolamine and/or atropine
    Patent number: 11739084
    Abstract: A synthetic route to scopolamine and/or atropine. In such context, the present invention identifies a method for preparing 6,7-dehydro atropine, which can be converted into either scopolamine and/or atropine, along with a method for converting a protected pyrrole into a tetrachlorobicylic compound, such as benzyl 3-oxo-8-azabicyclo[3.2.1]oct-6-ene-8-carboxylate.
    Type: Grant
    Filed: October 7, 2021
    Date of Patent: August 29, 2023
    Assignee: SOUTHWEST RESEARCH INSTITUTE
    Inventors: Shawn T. Blumberg, Paul W. Miguel, Daniel A. Hinojosa
  • Illudin analogs, uses thereof, and methods for synthesizing the same
    Patent number: 11739043
    Abstract: This invention provides illudin derivatives, intermediates, preparation methods, pharmaceutical compositions and uses thereof. Specific examples include novel synthetic routes to prepare illudin derivatives and an illudin derivative having a positive optical rotation, which has therapeutic value.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: August 29, 2023
    Assignee: Lantern Pharma Inc.
    Inventors: Gregory J. Tobin, Shawn T. Blumberg, Andrey D. Malakhov
  • PURIFICATION OF BIS-QUATERNARY PYRIDINIUM OXIMES
    Publication number: 20230242487
    Abstract: Purification of bis-quaternary pyridinium oximes (BQPO) which may serve as organophosphorus nerve agent antidotes.
    Type: Application
    Filed: February 1, 2022
    Publication date: August 3, 2023
    Inventors: Shawn T. BLUMBERG, Antonio MENCHACA, Christopher DORSEY, Asa WATERMAN
  • SYNTHETIC ROUTE TO SCOPOLAMINE AND/OR ATROPINE
    Publication number: 20230121306
    Abstract: A synthetic route to scopolamine and/or atropine. In such context, the present invention identifies a method for preparing 6,7-dehydro atropine, which can be converted into either scopolamine and/or atropine, along with a method for converting a protected pyrrole into a tetrachlorobicylic compound, such as benzyl 3-oxo-8-azabicyclo[3.2.1]oct-6-ene-8-carboxylate.
    Type: Application
    Filed: October 7, 2021
    Publication date: April 20, 2023
    Inventors: Shawn T. BLUMBERG, Paul W. MIGUEL, Daniel A. HINOJOSA
  • ILLUDIN ANALOGS, USES THEREOF, AND METHODS FOR SYNTHESIZING THE SAME
    Publication number: 20210198191
    Abstract: This invention provides illudin derivatives, intermediates, preparation methods, pharmaceutical compositions and uses thereof. Specific examples include novel synthetic routes to prepare illudin derivatives and an illudin derivative having a positive optical rotation, which has therapeutic value.
    Type: Application
    Filed: March 4, 2021
    Publication date: July 1, 2021
    Inventors: Gregory J. Tobin, Shawn T. Blumberg, Andrey D. Malakhov, Varsin A. Archer
  • Recrystallized HI-6 Dimethylsulfate
    Publication number: 20210138359
    Abstract: The present invention is directed at the synthesis and characterization of recrystallized HI-6 dimethylsulfate (DMS). The method can comprise dissolving HI-6 DMS in an alkyl-based glycol and adding an antisolvent to recrystallize HI-6 DMS or dissolving HI-6 DMS in methanol and adding dimethoxy ethane or dimethyl formamide as the antisolvent to recrystallize HI-6 DMS. The recrystallized HI-6 DMS indicates a resistance to moisture absorption and/or a DSC melting point onset (MP Onset) at least at or above 160.0° C.
    Type: Application
    Filed: November 10, 2020
    Publication date: May 13, 2021
    Inventors: Shawn T. BLUMBERG, Paul W. MIGUEL
  • Synthesis of oxime nerve agent antidotes
    Patent number: 10633340
    Abstract: The present invention relates to a new route to bis-quaternary pyridinium oximes which can be utilized to restore activity of acetylcholinesterase inhibited by combination with organophosphates.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: April 28, 2020
    Assignee: SOUTHWEST RESEARCH INSTITUTE
    Inventors: Shawn T. Blumberg, Antonio A Menchaca