Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase represented by formula (I): or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: A semantically aware relational database management system includes suitable programming to relate attributes of the relational database to semantic equivalents of such attributes. In response to receiving a query, the relational database management system performs at least one semantically aware operation on the data in the relational database in order to determine what data is to be retrieved in response to the query. Results of the query presented to a user may include data derived from performing the semantically aware operations.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The invention relates to compounds of the Formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X2, X4, X5 and X1 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of Formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of Formula 1.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase represented by formula (I): or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: A flexible workflow is described that includes a pocket of flexibility. The pocket of flexibility may include workflow fragments that may be joined together, subject to pre-defined constraints. In implementing the flexible workflow, a user may encounter the pocket of flexibility, and select from the fragments to construct a workflow that is consistent with the user's current needs. The fragments may be incrementally presented to the user on a user interface, such that only those fragments determined to be combinable in a valid way may be selected by the user. In this way, a user who may have little experience with workflow languages or terminology may be able to use the flexible workflow, and be confident that the result is valid. Thus, difficulties in dealing with change in workflow systems may be mitigated, and this mitigation may be achieved without compromising the simplicity and generic nature of a workflow language.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase, represented by structural formula I: or pharmaceutically acceptable salts thereof, wherein values of the variables of structural formula are as described in the specification and claims. The invention also provides pharmaceutically acceptable compositions comprising the compounds or salts, and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: A semantically aware relational database management system includes suitable programming to relate attributes of the relational database to semantic equivalents of such attributes. In response to receiving a query, the relational database management system performs at least one semantically aware operation on the data in the relational database in order to determine what data is to be retrieved in response to the query. Results of the query presented to a user may include data derived from performing the semantically aware operations.

Abstract: A semantically aware relational database management system includes suitable programming to relate attributes of the relational database to semantic equivalents of such attributes. In response to receiving a query, the relational database management system performs at least one semantically aware operation on the data in the relational database in order to determine what data is to be retrieved in response to the query. Results of the query presented to a user may include data derived from performing the semantically aware operations.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract: Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3?, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.

Abstract: A semantically aware relational database management system includes suitable programming to relate attributes of the relational database to semantic equivalents of such attributes. In response to receiving a query, the relational database management system performs at least one semantically aware operation on the data in the relational database in order to determine what data is to be retrieved in response to the query. Results of the query presented to a user may include data derived from performing the semantically aware operations.

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.