Patents by Inventor Shelley R. Holets-McCormack
Shelley R. Holets-McCormack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230302453Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.Type: ApplicationFiled: April 24, 2023Publication date: September 28, 2023Applicant: ABBOTT LABORATORIESInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew Fischer, John M. Robinson, Shelley R. Holets-McCormack, Sophie Laurenson
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Patent number: 11633738Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.Type: GrantFiled: October 3, 2017Date of Patent: April 25, 2023Assignee: ABBOTT LABORATORIESInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew Fischer, John M. Robinson, Shelley R. Holets-McCormack, Sophie Laurenson
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Patent number: 11578358Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. The detection modules disclosed here can be used for detecting analytes of interest which analytes may have been enriched by amplification, isolation, or other techniques.Type: GrantFiled: September 14, 2017Date of Patent: February 14, 2023Inventors: Mark A. Hayden, Jeffrey B. Huff, Sophie Laurenson, Andrew Fischer, John Robinson, Shelley R. Holets-McCormack
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Patent number: 11022598Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.Type: GrantFiled: October 3, 2017Date of Patent: June 1, 2021Assignee: ABBOTT LABORATORIESInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew S. Schapals, Anthony S. Muerhoff, M. Felicia Bogdan, Thomas Leary, Shelley R. Holets-McCormack, Sophie Laurenson, Andrew T. Fischer, Richard Haack, Stefan Hershberger, Dustin House, Lei Qiao, M. Shawn Murphy, Mark R. Pope, Edna M. Prieto-Ballengee, QiaoQiao Ruan, Pathik Soni, Sergey Tetin, Lyle Yarnell
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Publication number: 20200256843Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.Type: ApplicationFiled: May 1, 2020Publication date: August 13, 2020Applicant: ABBOTT LABORATORIESInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew S. Schapals, Anthony S. Muerhoff, M. Felicia Bogdan, Thomas Leary, Shelley R. Holets-McCormack, Sophie Laurenson, Andrew T. Fischer, Richard Haack, Stefan Hershberger, Dustin House, Lei Qiao, M. Shawn Murphy, Mark R. Pope, Edna M. Prieto-Ballengee, QiaoQiao Ruan, Pathik Soni, Sergey Tetin, Lyle Yarnell
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Publication number: 20190153524Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. The detection modules disclosed here can be used for detecting analytes of interest which analytes may have been enriched by amplification, isolation, or other techniques.Type: ApplicationFiled: September 14, 2017Publication date: May 23, 2019Inventors: Mark A. Hayden, Jeffrey B. Huff, Sophie Laurenson, Andrew Fischer, John Robinson, Shelley R. Holets-McCormack
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Publication number: 20180188230Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.Type: ApplicationFiled: October 3, 2017Publication date: July 5, 2018Applicant: ABBOTT LABORATORIESInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew S. Schapals, Anthony S. Muerhoff, Felicia Bogdan, Thomas Leary, Shelley R. Holets-McCormack, Sophie Laurenson, Andrew T. Fischer, Richard Haack, Stefan Hershberger, Dustin House, Lei Qiao, M. Shawn Murphy, Mark R. Pope, Edna M. Prieto-Ballengee, QiaoQiao Ruan, Pathik Soni, Sergey Tetin, Lyle Yarnell
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Publication number: 20180104694Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.Type: ApplicationFiled: October 3, 2017Publication date: April 19, 2018Applicant: ABBOTT LABORATORIESInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew Fischer, John M. Robinson, Shelley R. Holets-McCormack, Sophie Laurenson
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Publication number: 20180095067Abstract: Integrated microfluidic and analyte detection devices are disclosed, along with methods of detecting target analytes. Digital microfluidic and analyte detection devices include a first substrate and a second substrate aligned generally parallel to each other to define a gap therebetween, the first substrate including a plurality of electrodes to generate electrical actuation forces on a liquid droplet disposed in the gap; at least one reagent disposed on at least one of the first substrate or the second substrate and configured to be carried by the liquid droplet; and an analyte detection device in fluid communication with the gap, wherein the plurality of electrodes are configured to move the liquid droplet towards the analyte detection device.Type: ApplicationFiled: October 3, 2017Publication date: April 5, 2018Applicant: Abbott LaboratoriesInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew S. Schapals, Anthony S. Muerhoff, Felicia Bogdan, Thomas Leary, Shelley R. Holets-McCormack, Sophie Laurenson, Andrew T. Fischer, Richard Haack, Stefan Hershberger, Dustin House, Lei QIAO, M. Shawn Murphy, Mark R. Pope, Edna M. Prieto-Ballengee, QiaoQiao Ruan, Pathik Soni, Sergey Tetin, Lyle Yarnell, John M. Robinson
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Patent number: 8329415Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and non-specific animal immunoglobulins. Other aspects of the invention include related immunoassays and test kits.Type: GrantFiled: August 2, 2011Date of Patent: December 11, 2012Assignee: Abbott LaboratoriesInventor: Shelley R. Holets-McCormack
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Patent number: 8288111Abstract: The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosure provides such immunoassays where the hydrophobic drug is an immunosuppressant drug such as cyclosporine A.Type: GrantFiled: May 23, 2008Date of Patent: October 16, 2012Assignee: Abbott LaboratoriesInventors: Elaine M. Brate, David M. Finley, Shelley R. Holets-McCormack, David P. Pacenti, Ryan E. Piktel, Michelle L. Shields, Thomas G. Spring, Phillip P. Wang
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Publication number: 20110294140Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and non-specific animal immunoglobulins. Other aspects of the invention include related immunoassays and test kits.Type: ApplicationFiled: August 2, 2011Publication date: December 1, 2011Applicant: ABBOTT LABORATORIESInventor: Shelley R. Holets-McCormack
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Patent number: 7993851Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and non-specific animal immunoglobulins. Other aspects of the invention include related immunoassays and test kits.Type: GrantFiled: June 25, 2009Date of Patent: August 9, 2011Assignee: Abbott LaboratoriesInventor: Shelley R. Holets-McCormack
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Publication number: 20090325198Abstract: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and non-specific animal immunoglobulins. Other aspects of the invention include related immunoassays and test kits.Type: ApplicationFiled: June 25, 2009Publication date: December 31, 2009Applicant: ABBOTT LABORATORIESInventor: Shelley R. Holets-McCormack
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Publication number: 20080311676Abstract: The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosure provides such immunoassays where the hydrophobic drug is an immunosuppressant drug such as cyclosporine A.Type: ApplicationFiled: May 23, 2008Publication date: December 18, 2008Applicant: ABBOTT LABORATORIESInventors: Elaine M. Brate, David M. Finley, Shelley R. Holets-McCormack, David P. Pacenti, Ryan E. Piktel, Michelle Shields, Thomas G. Spring, Philip P. Wang