Abstract: A handy dental flosser has a housing (10) with a body and an extending tube (17), a winding wheel (11) rotatably attached inside the body of the housing (10), a string of dental floss (14) wound on the winding wheel (11) and tied to a distal end of the extending tube (17), and a locking device mounted on the housing (10) to detachably engage with the winding wheel (11) to release the dental floss. Thereby, the dental floss is easily replaced to renew a section between the winding wheel (11) and the distal end of the extending tube (17). Moreover, the handy dental flosser is conveniently used by one hand to clean teeth.