Abstract: An iontophoresis method for delivenng an active substance or drug to a target tissue which includes the step of sandwiching the target tissue between a donor electrode and receptor electrode which are each electrically connnected to a power source wherein a current path between the donor electrode and the receptor electrode is maintained at a minimum value to enhance delivery of the active substance to the target tissue.

Abstract: A vaso-active agent is administered in combination with a therapeutic agent which is useful in treatment of tissue of the body which is located below the stratum corneum or the outermost layer of the epidermis, wherein the vaso-active agent may be administered by a local, topical or transdermal route to a particular site and the therapeutic agent may be administered in a similar manner in combination with the vaso-active agent or may be administered separately, wherein the vaso-active agent and the therapeutic agent for topical and/or transdermal administration may be provided in the form of a composition so as to increase local perfusion and/or concentration of the therapeutic agent at or adjacent an administration site of the vaso-active agent.