Abstract: The present invention relates to a protective sleeve for a chronically-implanted intravenous (IV) site. The sleeve is made of a prophylactic waterproof material, and is normally worn by a person while showering to prevent moisture from invading the IV site. The sleeve in one embodiment has two elastomeric beads which form a watertight seal between a person's arm and the beads, and the sleeve billows in its mid-section so that it does not snag the catheter. The sleeve in another embodiment has a binding at one end and at least a binding at the other end integrally formed in the sleeve or in another embodiment a plurality of indentations axially spaced on a tapered portion of the sleeve.