Patents by Inventor Shihong Li
Shihong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11989881Abstract: A method and system for acquiring scan data. The system includes a processing device and an imaging device. The processing device is configured to generate a target protocol group corresponding to a plurality of target bed positions by adjusting, based on a reference image, at least one parameter of an initial protocol group. The target protocol group includes a target general protocol for localizing the plurality of target bed positions and a plurality of target primary protocols for localizing each of the plurality of target bed positions. The imaging device is configured to acquire scan data by scanning the object based on the target protocol group.Type: GrantFiled: April 18, 2022Date of Patent: May 21, 2024Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.Inventors: Cuifang Li, Shihong Han, Gongze Zhu
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Publication number: 20240071726Abstract: The present disclosure relates to the technical field of composite coating preparation, in particular to a method for plasma-assisted and multi-step continuous preparation of a diffusion layer/amorphous carbon film composite coating and use thereof. In the present disclosure, a high-temperature plasma carburizing/nitriding technology and a low-temperature plasma carbon coating technology are combined by a plasma activation technology with argon ion under gradient cooling, and the surface of a material is activated by multiple bombardment on the surface of the material with high-energy argon ions. In this way, a cluster-like porous and loose structure on a surface of the diffusion layer is removed.Type: ApplicationFiled: August 25, 2023Publication date: February 29, 2024Inventors: Yang YANG, Shihong ZHANG, Jun ZHENG, Jie LI, Jinming XIE
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Publication number: 20240051006Abstract: Disclosed are a stamping method and a deep-drawing die for an aluminum alloy liner of a large-volume hydrogen storage cylinder, which solve that technical problem of low production efficiency of processing the aluminum alloy liner of the large-volume hydrogen storage cylinder by adopting strong spin and thinning of an aluminum tube in the prior art. The stamping method includes heating and stamping an aluminum ingot into a cup-shaped rough blank, then cold deep drawing the cup-shaped rough blank for thinning and lengthening into an aluminium alloy liner, and the deep-drawing die includes terrace die and thinning dies.Type: ApplicationFiled: April 19, 2023Publication date: February 15, 2024Inventors: Shihong LI, Cunjiang FENG, Hao YI, Qingbo GONG, Qinling HE, Jiachao HE, Yong TANG, Na QI
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Patent number: 10323046Abstract: Provided is a method for preparing L-BPA, which includes steps of: reacting N-protected (S)-4-halophenylalanine of Formula I, a boronating agent, Grignard reagent and bis(2-dimethylaminoethyl)ether to obtain a reaction mixture, wherein the reaction mixture comprises N-protected (S)-4-boronophenylalanine of Formula II and the R2 group represents a protecting group; isolating the N-protected (S)-4-boronophenylalanine from the reaction mixture; and deprotecting the R2 group of the N-protected (S)-4-boronophenylalanine to obtain L-BPA, wherein the L-BPA has a structure of Formula III.Type: GrantFiled: February 1, 2018Date of Patent: June 18, 2019Assignee: NEUBORON MEDTECH LTD.Inventors: Shihong Li, Jing He, Yuanhao Liu, Zheng Wang
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Publication number: 20190054319Abstract: The present disclosure discloses a boron neutron capture therapy system comprising: a boron neutron capture therapy device and an ?-amino acid-like boron trifluoride compound having a structure shown as formula (I) below: Wherein: R is selected from hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl, hydroxymethyl, 1-hydroxyethyl, benzyl or hydroxybenzyl; M is H or metal atom. The energy generated from the action of the neutron beam generated by the boron neutron capture therapy device on the ?-amino acid-like boron trifluoride compound destroys tumor cell DNA. In another aspect, the present disclosure discloses a use of an ?-amino acid-like boron trifluoride compound in the preparation of a medicament for tumor therapy.Type: ApplicationFiled: September 18, 2018Publication date: February 21, 2019Inventors: Zheng WANG, Shihong Li, Zhigang Luo, Yuanhao Liu
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Publication number: 20180155368Abstract: Provided is a method for preparing L-BPA, which includes steps of: reacting N-protected (S)-4-halophenylalanine of Formula I, a boronating agent, Grignard reagent and bis(2-methylaminoethyl)ether to obtain a reaction mixture, wherein the reaction mixture comprises N-protected (S)-4-boronophenylalanine of Formula II and the R2 group represents a protecting group; isolating the N-protected (S)-4-boronophenylalanine from the reaction mixture; and deprotecting the R2 group of the N-protected (S)-4-boronophenylalanine to obtain L-BPA, wherein the L-BPA has a structure of Formula III.Type: ApplicationFiled: February 1, 2018Publication date: June 7, 2018Inventors: Shihong LI, Jing He, Yuanhao Liu, Zheng Wang
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Patent number: 9938522Abstract: This invention relates to linking, amplifying and sequencing of two ends of long linear DNAs. In particular, this invention provides methods for pairing and sequencing VH and VL genes that encode two parts of one immunoglobulin. The method of the present invention can be applied to rapid antibody discovery and engineering.Type: GrantFiled: September 25, 2015Date of Patent: April 10, 2018Assignee: GENEWIZ, INC.Inventors: Shihong Li, Narisra Jongkam, Ruqin Kou, Hairong Duan, Zhenzhen Zhou, Shifang Zhang
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Patent number: 9745611Abstract: Disclosed herein are compositions with uniquely designed oligonucleotide primers for identifying a plurality of microorganisms in a sample, and improved methods for detection of microbial populations from diverse biological and environmental samples.Type: GrantFiled: May 6, 2014Date of Patent: August 29, 2017Assignee: GENEWIZ INC.Inventors: Jun Huang, Zhenzhen Zhou, Hairong Duan, Xin Wu, Shihong Li
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Patent number: 9441271Abstract: This disclosure provides methods and compositions for amplification and sequencing of DNA templates, comprising at least two of: 2?-deoxyinosine-5? triphosphate, 5-propynyl-2?-deoxycytidine-5?-triphosphate, and 8-oxo-2?-deoxyguanosine-5?-triphosphate. Incorporation of these promoting nucleotides into amplification and sequencing reactions improves the amplification and sequencing of difficult-to-sequence DNA regions such as a GC rich regions or GT rich regions; repetitive sequences, including dinucleotide, trinucleotide, direct, inverted, Alu, poly A or poly T repeats; and hairpin or other secondary structures.Type: GrantFiled: June 1, 2015Date of Patent: September 13, 2016Assignee: GENEWIZ INC., SUZHOUInventors: Shihong Li, Narisra Jongkam, Shifang Zhang, Conrad Leung
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Publication number: 20160090590Abstract: This invention relates to linking, amplifying and sequencing of two ends of long linear DNAs. In particular, this invention provides methods for pairing and sequencing VH and VL genes that encode two parts of one immunoglobulin. The method of the present invention can be applied to rapid antibody discovery and engineering.Type: ApplicationFiled: September 25, 2015Publication date: March 31, 2016Applicant: GENEWIZ, INC.Inventors: Shihong Li, Narisra Jongkam, Ruqin Kou, Hairong Duan, Zhenzhen Zhou, Shifang Zhang
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Publication number: 20150322492Abstract: Disclosed herein are compositions with uniquely designed oligonucleotide primers for identifying a plurality of microorganisms in a sample, and improved methods for detection of microbial populations from diverse biological and environmental samples.Type: ApplicationFiled: May 6, 2014Publication date: November 12, 2015Inventors: Jun HUANG, Zhenzhen ZHOU, Hairong DUAN, Xin WU, Shihong LI
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Patent number: 9150914Abstract: This disclosure provides methods and compositions for amplification and sequencing of DNA templates, comprising at least two of: 2?-deoxyinosine-5? triphosphate, 5-propynyl-2?-deoxycytidine-5?-triphosphate, and 8-oxo-2?-deoxyguanosine-5?-triphosphate. Incorporation of these promoting nucleotides into amplification and sequencing reactions improves the amplification and sequencing of difficult-to-sequence DNA regions such as a GC rich regions or GT rich regions; repetitive sequences, including dinucleotide, trinucleotide, direct, inverted, Alu, poly A or poly T repeats; and hairpin or other secondary structures.Type: GrantFiled: March 28, 2013Date of Patent: October 6, 2015Assignee: Genewiz Inc., SuzhouInventors: Shihong Li, Narisra Jongkam, Shifang Zhang, Conrad Leung
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Publication number: 20150259733Abstract: This disclosure provides methods and compositions for amplification and sequencing of DNA templates, comprising at least two of: 2?-deoxyinosine-5? triphosphate, 5-propynyl-2?-deoxycytidine-5?-triphosphate, and 8-oxo-2?-deoxyguanosine-5?-triphosphate. Incorporation of these promoting nucleotides into amplification and sequencing reactions improves the amplification and sequencing of difficult-to-sequence DNA regions such as a GC rich regions or GT rich regions; repetitive sequences, including dinucleotide, trinucleotide, direct, inverted, Alu, poly A or poly T repeats; and hairpin or other secondary structures.Type: ApplicationFiled: June 1, 2015Publication date: September 17, 2015Applicant: GENEWIZ INC., SUZHOUInventors: Shihong LI, Narisra JONGKAM, Shifang ZHANG, Conrad LEUNG
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Publication number: 20130316352Abstract: This disclosure provides methods and compositions for amplification and sequencing of DNA templates, comprising at least two of: 2?-deoxyinosine-5? triphosphate, 5-propynyl-2?-deoxycytidine-5?-triphosphate, and 8-oxo-2?-deoxyguanosine-5?-triphosphate. Incorporation of these promoting nucleotides into amplification and sequencing reactions improves the amplification and sequencing of difficult-to-sequence DNA regions such as a GC rich regions or GT rich regions; repetitive sequences, including dinucleotide, trinucleotide, direct, inverted, Alu, poly A or poly T repeats; and hairpin or other secondary structures.Type: ApplicationFiled: March 28, 2013Publication date: November 28, 2013Inventors: Shihong LI, Narisra JONGKAM, Shifang ZHANG, Conrad LEUNG
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Patent number: 8420341Abstract: This invention relates to assays for detecting and measuring ADP. In particular, this invention provides homogeneous luminescent assays that detect ADP generation and measures ADP accumulation based on enzymatic coupling reactions. The assays of the present invention can be applied to all types of kinases and other ADP-generating enzymes, are antibody free, beads free, radioisotope free, and compatible with commonly used kinase buffers.Type: GrantFiled: November 12, 2008Date of Patent: April 16, 2013Assignee: Genewiz Inc., SuzhouInventors: Zhong-Ping Sun, Shihong Li, Conrad Leung, Guo-Juan Liao
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Publication number: 20100227344Abstract: This invention relates to assays for detecting and measuring ADP. In particular, this invention provides homogeneous luminescent assays that detect ADP generation and measures ADP accumulation based on enzymatic coupling reactions. The assays of the present invention can be applied to all types of kinases and other ADP-generating enzymes, are antibody free, beads free, radioisotope free, and compatible with commonly used kinase buffers.Type: ApplicationFiled: November 12, 2008Publication date: September 9, 2010Applicant: GENEWIZ INC.Inventors: Zhong-Ping Sun, Shihong Li, Conrad Leung, Guo-Juan Liao
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Patent number: 6479418Abstract: The invention relates to a process for preparing a porous ceramic body, which process is based on a negative replica method. The invention further relates to a ceramic body obtainable by said method and to its use as a scaffold for tissue engineering.Type: GrantFiled: December 15, 2000Date of Patent: November 12, 2002Assignee: IsoTis N.V.Inventors: Shihong Li, Klaas de Groot, Pierre Jean F. Layrolle, Clemens Antoni van Blitterswijk, Joost Robert de Wijn
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Publication number: 20020037799Abstract: The invention relates to a process for preparing a porous ceramic body, which process is based on a negative replica method. The invention further relates to a ceramic body obtainable by said method and to its use as a scaffold for tissue engineering.Type: ApplicationFiled: December 15, 2000Publication date: March 28, 2002Inventors: Shihong Li, Klaas de Groot, Pierre Jean F. Layrolle, Clemens Antoni van Blitterswijk, Joost Robert de Wijn