Abstract: Multifunctional intelligent invisible orthodontic braces include upper braces, lower braces and a chip. The upper braces and the lower braces respectively include an inner soft layer and an outer hard layer. The inner soft layer is attached to the periphery of the tooth. The outer hard layer is laminated on the outer side of the inner soft layer. The chip is arranged on the outer side of the outer hard layer or arranged between the inner soft layer and the outer hard layer. A monitor for detecting the wearing time is arranged in the chip. In the present invention, the inner soft layer is additionally arranged in the outer hard layer. This structure has the following advantages: the improved braces is a double-layer structure and is soft inside and hard outside. The attachment between the inner soft layer and the tooth is better.

Abstract: A receptacle connector includes an insulative housing, a number of conductive contacts, and a retainer seat. The insulative housing includes a mating face for mating with a plug connector and a mounting face opposite to the mating face. The insulative housing defines a number of contact-receiving passages penetrating from the mating face to the mounting face and a mounting recess recessed from the mounting face toward the mating face a certain distance. The conductive contacts are respectively received in the contact-receiving passages. Each conductive contact includes a contacting portion for electrically contacting the plug connector, a termination portion for electrically connecting with a Printed Circuit Board, and an intermediate portion connecting the contacting portion with the termination portion. The retainer seat is fixedly received in the mounting recess of the insulative housing.

Abstract: A receptacle connector includes an insulative housing, a number of conductive contacts, and a retainer seat. The insulative housing includes a mating face for mating with a plug connector and a mounting face opposite to the mating face. The insulative housing defines a number of contact-receiving passages penetrating from the mating face to the mounting face and a mounting recess recessed from the mounting face toward the mating face a certain distance. The conductive contacts are respectively received in the contact-receiving passages. Each conductive contact includes a contacting portion for electrically contacting the plug connector, a termination portion for electrically connecting with a Printed Circuit Board, and an intermediate portion connecting the contacting portion with the termination portion. The retainer seat is fixedly received in the mounting recess of the insulative housing.

Abstract: An electrical connector assembly includes an insulative housing, a number of contacts, a least a first PCB electrically connecting with the contacts, a pair of restriction sections, and a pair of fastening elements. The insulative housing comprises an upper wall, a lower wall opposite to the upper wall, and a pair of sidewalls connecting with the upper and lower walls. The contacts are received in the insulative housing. The first PCB comprises a pair of side sections partially surrounding the insulative housing. The pair of restriction sections is connected with the sidewalls of the insulative housing and partially overlaps with side sections of the first PCB. The pair of fastening elements respectively passes through the restriction sections and the side sections of the first PCB to align and position the relative position between the insulative housing and the first PCB for achieving more reliably electrical connection between the first PCB and the contacts.

Abstract: Multi-modal tumor imaging of neuroblastoma is essential for tumor staging, response evaluation and detection of relapsed diseased. The present invention provides a norepinephine analogue with a near-infrared (near-IR) dye, W765-BG, that efficiently and stably detects neuroblastoma in vivo using near-IR optical imaging. Confocal microscopy and optical imaging of neuroblastoma xenografts shows cell specific uptake and reveals exceptional tumor retention with a high tumor-to-tissue ratio up to 7 days after injection of W765-BG.

Abstract: The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at the cellular level by confocal microscopy, and in vivo in a whole animal using a various xenograft models. The specific uptake of this agent in human cancer cells and multiple xenograft models demonstrate that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for early stage cancer studies and diagnoses. Also, the present invention provides that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for visualization of drug redistribution within the body which is useful in determining the optimal biological dose. Ultimately, the visualization data can be used as an analytical tool to reduce any systemic toxicity.

Abstract: The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf; SEQ ID NO. 3) NIR imaging compositions and novel cyclic HWGFTL (SEQ ID NO. 5) polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.

Abstract: The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf) NIR imaging compositions and novel cyclic HWGFTL polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.

Abstract: Conjugate molecules comprising a ligand or targeting moiety bonded to a polymer spacer, a polymer carrier bonded to the polymer spacer, and a therapeutic agent bound to the polymer carrier (with or without a linker) are disclosed. The conjugate molecules are useful for the selective delivery of therapeutic agents to tumors or other tissues expressing biological receptors.