Abstract: The present invention relates to a method for constructing quadrants corresponding to different diseases in a frame of concentrations of multiple independent biomarkers, comprising: (a) transferring original distributed concentrations of every independent biomarker to modified distributed concentrations, comprising: calculating the mean value and the standard deviation of the original distributed concentrations for a given independent biomarker; individually subtracting all the original distributed concentrations by the mean value for the given independent biomarker; and individually dividing all the differences by the standard deviation to get the modified distributed concentrations for the given independent biomarker; (b) positing the modified distributed concentrations in a frame of multiple independent biomarkers; and (c) finding a boundary optimally separating neighboring quadrants corresponding to different diseases.

Abstract: The present invention provides a method for clinically identifying Parkinson disease with normal cognition or Parkinson disease dementia in a subject.

Abstract: The present invention provides a method for clinically identifying Parkinson disease with normal cognition or Parkinson disease dementia in a subject.

Abstract: The present invention provides a method for identifying Parkinson disease with normal cognition or Parkinson disease dementia in a subject.

Abstract: The present invention relates to a method for calculating the change of signals starting from the originally detected temporal signals (_102 ), comprising the following steps: (a) eliminating the drift in the originally detected temporal signals with time to get ?i signals; (b) removing the xi signals existing outside the range of 80% to 120% of the averaged value of all the ?i signals to get residual signals as x 2 signals; (c) dividing the ?2 signals into 14-100 sections; (d) finding the averaged value of the ?2 signals in each section to get ?3 signals; (e) optionally neglecting one or two of the first ?3 signals and selecting six to nine ?3 signals with the smallest value of standard deviation in initial sections, wherein the initial sections are the first one-fourth part to half part of all sections; (f) eliminating the drift in the selected ?3 signals of step (e) with time to get ?4 signals; (g) selecting six to nine ?3 signals with the smallest value of standard deviation in terminal sections, wherein

Abstract: The present invention relates to a method for constructing quadrants corresponding to different diseases in a frame of concentrations of multiple independent biomarkers, comprising: (a) transferring original distributed concentrations of every independent biomarker to modified distributed concentrations, comprising: calculating the mean value and the standard deviation of the original distributed concentrations for a given independent biomarker; individually subtracting all the original distributed concentrations by the mean value for the given independent biomarker; and individually dividing all the differences by the standard deviation to get the modified distributed concentrations for the given independent biomarker; (b) positing the modified distributed concentrations in a frame of multiple independent biomarkers; and (c) finding a boundary optimally separating neighboring quadrants corresponding to different diseases.

Abstract: A method for detecting the risk of Alzheimer's disease comprises detecting immunomagnetic reduction signals of two biological markers in a biological sample from a subject, wherein the two biological markers are tau protein and A?-42 protein; and calculating concentrations of the above two biological markers and using the product of the concentrations of the above two biological markers to diagnose the risk of Alzheimer's disease, wherein the concentration is calculated by the conversion of the magnetic reduction signals.

Abstract: The present invention provides a method for detecting the risk of Alzheimer's disease, comprising detecting immunomagnetic reduction signals of two biological markers in a biological sample from a subject, wherein the two biological markers is tau protein and A?-42 protein, respectively; and calculating concentrations of the above two biological markers and using the product of the concentrations of the above two biological markers to diagnosing the risk of Alzheimer's disease, wherein the concentration is calculated by the conversion of the magnetic reduction signals.

Abstract: The present invention relates to a food product which has been fortified in iron content, comprising a Fe3O4 sphere. The present invention also relates to an iron-containing additive for use in the above food product, in the form of a Fe3O4 sphere. The present invention further relates to a method for preparing the above food product, comprising the steps of adding or mixing the iron-containing additive in solid or dispersed form with the food product, wherein the iron-containing additive is in the form of a Fe3O4 sphere.

Abstract: A device for measuring alternating current (AC) magnetic susceptibility and the method for measuring the same are provided. The device comprises an AC magnetic susceptibility coil set, a signal capturing unit, and a signal processing unit. The device detects AC magnetic susceptibility signals from under testing particles in the magnetic field with variable AC frequencies, and extracts the AC magnetic susceptibility intensity variation and phase difference and/or the real part and the imaginary part of the AC magnetic susceptibility by the signal processing unit.

Abstract: The invention provides a low-field nuclear magnetic resonance system for measuring a magnetic resonance signal of an object. The low-field nuclear magnetic resonance system includes a pre-magnetization module, a uniform magnetic field coil module, a pulse and receiving coil module, a filter amplifier module, a signal acquisition module and a processing module. The pre-magnetization module is used to establish a pre-magnetization field in the object to increase magnetization of the object. The uniform magnetic field coil module is used to change a resonance frequency and background magnetic field intensity of the object during nuclear magnetic resonance measurement by regulating a magnetic field of the coil. The processing module further includes a programming object for controlling timing processing and signal analysis of the measurement process.

Abstract: The present invention relates to a food product which has been fortified in iron content, comprising a Fe3O4 sphere. The present invention also relates to an iron-containing additive for use in the above food product, in the form of a Fe3O4 sphere. The present invention further relates to a method for preparing the above food product, comprising the steps of adding or mixing the iron-containing additive in solid or dispersed form with the food product, wherein the iron-containing additive is in the form of a Fe3O4 sphere.

Abstract: Present invention relates to a device magnetically separating a sample. The preferred material for the device is plastic. The device is a cuboid plate, which consists of one or two bottom sides and at least two lateral sides. The bottom side has wells on it to accommodate magnetic elements, and the magnetic element which is suitable to be accommodated into the wells comprising column shape, half-column shape, or half circular column shape magnetic elements. The magnetic element comprises permanent magnet or electromagnet, and the permanent magnet is selected from the group consisting of alnico, samarium cobalt, neodymium iron boron, or magnetic ceramic materials. The magnetic elements can adsorb the magnetic samples in the micro plate.

Abstract: The invention relates to a method for stabilizing ac magnetic susceptibility of a magnetic fluid, comprising the following steps: (A) preparing two reagents of known magnetic concentration, including a first one in a mixture of an xC1 ?l, m1-emu/g magnetic fluid and a yC1 ?l PBS solution and a second one in a mixture of an xC2 ?l, m2-emu/g magnetic fluid and a yC2 ?l PBS solution, in addition to a to-be-detected reagent in a mixture of an xS ?l, mS-emu/g magnetic fluid and a yS ?l PBS solution: (B) detecting alternatively ?ac,o signals; (C) calculating a new ?ac,o value, i.e. ?ac,cal, for S via ? ac , cal = ? ac , o , S - ? ac , o , C ? ? 1 ? ac , o , C ? ? 2 - ? ac , o , C ? ? 1 × ( x C ? ? 2 - x C ? ? 1 ) + ? C ? ? 1 ; and (D) repeating steps (B) and (C) to find the ?ac,cal for a next run, and then finding a time dependent ?ac,cal for S.

Abstract: The invention provides a high resolution proton nuclear magnetic reonance and imaging (NMR/MRI) in microtesla magnetic fields by using high critical temperature (high-Tc) superconducting quantum interference device (SQUID) magnetometer via a flux transformer. Both the SQUID and the input coupling coil are installed inside a superconducting vessel which shields environmental noise and set the SQUID in a stable operation condition. The present invention also offers the advantages of preserving the NMR signal even if the sample is far away from the SQUID detector.

Abstract: Disclosed is an apparatus for measuring ac magnetization at mixture frequency. The apparatus includes an ac generating unit for generating at least a first current with a frequency f1 and a second current with a frequency f2. The apparatus further includes a co-axial solenoid unit, driven by the first and second ac currents, to generate a first magnetic field and a second magnetic field. A pick-up solenoid is for disposing sample for detecting an ac magnetization of the sample and multiple frequency-component signals corresponding to various frequency combinations of f1 and f2 are output. The apparatus further includes a signal processing circuit for receiving the frequency-component signals, where the signal processing circuit obtains the ac magnetization of the sample at a target frequency of (?Tf1+?Tf2), which ?T and ?T are positive integers and the frequency f1 and the frequency f2 are two different frequencies.

Abstract: The invention provides a low-field nuclear magnetic resonance system for measuring a magnetic resonance signal of an object. The low-field nuclear magnetic resonance system includes a pre-magnetization module, a uniform magnetic field coil module, a pulse and receiving coil module, a filter amplifier module, a signal acquisition module and a processing module. The pre-magnetization module is used to establish a pre-magnetization field in the object to increase magnetization of the object. The uniform magnetic field coil module is used to change a resonance frequency and background magnetic field intensity of the object during nuclear magnetic resonance measurement by regulating a magnetic field of the coil. The processing module further includes a programming object for controlling timing processing and signal analysis of the measurement process.

Abstract: A method for suppressing non-specific bindings between molecules includes providing magnetic particles dispersed in a liquid, wherein each of the magnetic particles has a magnetization. The magnetic particles are coated with coating molecules. Binding molecules mixed of first-type binding molecules and second-type binding molecules are applied to the liquid, wherein the coating molecules are specifically binding with the first-type binding molecules and non-specifically binding with the second-type binding molecules. An alternating current (ac) magnetic field is applied at an axis with a frequency level, wherein the frequency level causes suppression of the second-type binding molecules in binding with the coating molecules.

Abstract: An ultra-sensitive, wash-free method for quantitatively determining the concentration of biomolecules in a sample solution is provided. The sensitivity of the method is 1 ppt or below. The method includes providing a reagent containing magnetic nanoparticles and measuring the ac magnetic susceptibility of the reagent. Then, a sample solution containing either multiple-active epitope biomolecules or single-active-epitope biomolecules is mixed with the reagent. The ac magnetic susceptibility of the reagent after the association with the biomolecules is measured. Thereafter, the difference in the ac magnetic susceptibility of the reagent before and after the association with the biomolecules is measured and the concentration of biomolecules in the sample solution is determined.

Abstract: The present invention provides a method for rapid detecting tumor. Moreover, this invention uses only the T1?1 value as a parameter to distinguish tumor from normal tissue, and the accuracy of this detection is highly reliable.