Patents by Inventor Shigehiro Takase
Shigehiro Takase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8598115Abstract: A compound useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, is provided. A fungus Acremonium persicinum was collected, and cyclic compounds were isolated from culture liquids thereof. The present inventors confirmed that the cyclic compounds or salts thereof have a potent antifungal activity and are useful as medicaments, particularly an antifungal agent, and thus the present invention was completed. The cyclic compound and the salt thereof according to the present invention can be used as an agent for preventing or treating mycoses, particularly deep-seated mycoses.Type: GrantFiled: March 13, 2009Date of Patent: December 3, 2013Assignee: Astellas Pharma Inc.Inventors: Ikuko Nakamura, Koji Yoshikawa, Keisuke Ohsumi, Ryuichi Kanasaki, Shigehiro Takase
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Patent number: 8592378Abstract: The present invention relates to a new compound useful as a modulator of melanocortin receptors. In particular, the present invention relates to a compound WS727713, a process for production of the compound by culturing, in a culture medium, a WS727713-producing strain belonging to Pseudonocardia and recovering the compound from a culture broth, a pharmaceutical composition containing the compound, and uses of the compound.Type: GrantFiled: January 19, 2012Date of Patent: November 26, 2013Assignee: Telsar Pharma Inc.Inventors: Takanao Otsuka, Hirotsugu Ueda, Keiko Fujie, Hideyuki Muramatsu, Michizane Hashimoto, Shigehiro Takase
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Publication number: 20120214731Abstract: The present invention relates to a new compound useful as a modulator of melanocortin receptors. In particular, the present invention relates to a compound WS727713, a process for production of the compound by culturing, in a culture medium, a WS727713-producing strain belonging to Pseudonocardia and recovering the compound from a culture broth, a pharmaceutical composition containing the compound, and uses of the compound.Type: ApplicationFiled: January 19, 2012Publication date: August 23, 2012Inventors: Takanao Otsuka, Hirotsugu Ueda, Keiko Fujie, Hideyuki Muramatsu, Michizane Hashimoto, Shigehiro Takase
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Patent number: 8133713Abstract: The present invention relates to a new compound useful as a modulator of melanocortin receptors.Type: GrantFiled: April 9, 2010Date of Patent: March 13, 2012Assignee: Astellas Pharma Inc.Inventors: Takanao Otsuka, Hirotsugu Ueda, Keiko Fujie, Hideyuki Muramatsu, Michizane Hashimoto, Shigehiro Takase
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Publication number: 20110015121Abstract: A compound useful as an antifungal agent, particularly a therapeutic agent for deep-seated mycoses, is provided. A fungus Acremonium persicinum was collected, and cyclic compounds were isolated from culture liquids thereof. The present inventors confirmed that the cyclic compounds or salts thereof have a potent antifungal activity and are useful as medicaments, particularly an antifungal agent, and thus the present invention was completed. The cyclic compound and the salt thereof according to the present invention can be used as an agent for preventing or treating mycoses, particularly deep-seated mycoses.Type: ApplicationFiled: March 13, 2009Publication date: January 20, 2011Inventors: Ikuko Nakamura, Koji Yoshikawa, Keisuke Ohsumi, Ryuichi Kanasaki, Shigehiro Takase
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Publication number: 20100297735Abstract: The present invention relates to a new compound useful as a modulator of melanocortin receptors.Type: ApplicationFiled: April 9, 2010Publication date: November 25, 2010Inventors: Takanao Otsuka, Hirotsugu Ueda, Keiko Fujie, Hideyuki Muramatsu, Michizane Hashimoto, Shigehiro Takase
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Patent number: 7741085Abstract: The present invention relates to a compound WS727713, useful as a modulator of melanocortin receptors, and a process for its production by culturing in a culture medium the actinomycetes strain of the genus Pseudonocardia, deposit number FERM BP-7570 and recovering the compound.Type: GrantFiled: March 22, 2005Date of Patent: June 22, 2010Assignee: Astellas Pharma Inc.Inventors: Takanao Otsuka, Hirotsugu Ueda, Keiko Fujie, Hideyuki Muramatsu, Michizane Hashimoto, Shigehiro Takase
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Patent number: 7696167Abstract: A cyclic peptide compound of the following general formula (I): Wherein R1, R2 and R3 are defined in the description, or a salt thereof. The compound (I) is useful for the prophylactic and/or therapeutic treatment of hepatitis C.Type: GrantFiled: November 21, 2005Date of Patent: April 13, 2010Assignee: Astellas Pharma Inc.Inventors: Motoo Kobayashi, Satoshi Sasamura, Hideyuki Muramatsu, Yasuhisa Tsurumi, Shigehiro Takase, Kazuki Okada
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Publication number: 20080214447Abstract: A cyclic peptide compound of the following general formula (I): Wherein R1, R2 and R3 are defined in the description, or a salt thereof. The compound (I) is useful for the prophylactic and/or therapeutic treatment of hepatitis C.Type: ApplicationFiled: November 21, 2005Publication date: September 4, 2008Applicant: Astellas Pharma Inc.Inventors: Motoo Kobayashi, Satoshi Sasamura, Hideyuki Muramatsu, Yasuhisa Tsurumi, Shigehiro Takase, Kazuki Okada
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Publication number: 20070254829Abstract: The present invention relates to a new compound useful as a modulator of melanxocortin receptors.Type: ApplicationFiled: March 22, 2005Publication date: November 1, 2007Applicant: ASTELLAS PHARMA INC.Inventors: Takanao Otsuka, Hirotsugu Ueda, Keiko Fujie, Hideyuki Muramatsu, Michizane Hashimoto, Shigehiro Takase
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Patent number: 6730776Abstract: The present invention provides a new antimicrobial compound WF14573, and a process for producing WF14573 by (a) culturing a WF14573A and/or B-producing microorganism in a nutrient medium and recovering WF14573A and/or B from the resultant cultured broth or (b) deacylating WF14573A and/or B in the presence of a microbial substance which is capable of deacylating WF14573A and/or B. Also provided are an antimicrobial agent comprising WF14573 and carrier(s), a pharmaceutical composition comprising an effective amount of WF14573 and pharmaceutically acceptable carrier(s), a method for killing microorganisms by applying WF14573 to the microorganisms, and use of WF14573 for the treatment of infectious diseases caused by pathogenic microorganisms.Type: GrantFiled: September 18, 2000Date of Patent: May 4, 2004Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yasuhiro Hori, Shigehiro Takase, Yasuhisa Tsurumi, Michizane Hashimoto, Motohiro Hino
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Publication number: 20040082757Abstract: This invention relates to new polypeptide compound represented by the following formula (I), wherein R1, R2, R3, R4, R5, R6, and R7 are described in the specification, or a salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.Type: ApplicationFiled: August 25, 2003Publication date: April 29, 2004Inventors: Katsuhiko Ito, Yutaka Nishihara, Mitsutaka Matsurura, Kazumi Kawai, Masayoshi Kinoshita, Tomoji Higaki, Shigehiro Takase, Hidenori Ohki
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Patent number: 6656905Abstract: A cyclic tetrapeptide compound and use thereof.Type: GrantFiled: May 4, 2001Date of Patent: December 2, 2003Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroaki Mori, Kazutoshi Sakamoto, Yasuhisa Tsurumi, Shigehiro Takase, Motohiro Hino
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Patent number: 6521600Abstract: The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprising the compound and pharmaceutically acceptable carrier, a use of the WF002 as a medicament and use of the compound for manufacture of the medicament for treatment of infectious disease.Type: GrantFiled: January 18, 2001Date of Patent: February 18, 2003Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yasuhiro Hori, Masami Ezaki, Yasuhisa Tsurumi, Shigehiro Takase, Motohiro Hino
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Patent number: 6399567Abstract: This invention relates to new polypeptide compounds represented by the following formula (I): wherein R1 is as defined in the description or a salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious disease including Pneumocystis carinii infection (e.g., Pneumocystis carinii pneumonia) in a human being or an animal.Type: GrantFiled: June 16, 1999Date of Patent: June 4, 2002Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ryuichi Kanasaki, Shigehiro Takase, Michizane Hashimoto, Hiroshi Hatanaka, Kazutoshi Sakamoto, Seiji Hashimoto, Nobuyuki Shiraishi, Hidenori Ohki, Kohji Kawabata
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Patent number: 6331521Abstract: The invention relates to new polypeptide compounds represented by the following formula [I]: wherein R1 is hydrogen, etc, R2 is hydrogen, etc, R3 is hydrogen, etc, and R4 is hydrogen, etc, or a salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.Type: GrantFiled: December 1, 1999Date of Patent: December 18, 2001Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Yasuhiro Hori, Yasuhisa Tsurumi, Shigehiro Takase, Hiroshi Hatanaka, Kazutoshi Sakamoto, Seiji Hashimoto, Hidenori Ohki, Takashi Tojo, Keiji Matsuda, Kohji Kawabata
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Patent number: 6110933Abstract: The present invention relates to a novel fatty acid derivative of the following formula: ##STR1## wherein R.sup.1 is acyl group, etc.;R.sup.2 is acyl(lower)alkyl;R.sup.3 is lower alkyl, etc.;R.sup.4 is hydrogen, etc.; andX is --O--, etc;and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.Type: GrantFiled: November 12, 1996Date of Patent: August 29, 2000Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Shigehiro Takase, Nobuharu Shigematsu, Seiji Yoshimura, Satoshi Okada, Keiji Hemmi, deceased, Hirokazu Tanaka, Takanao Otsuka, Yasuhisa Tsurumi, Masanori Okamoto, Masakuni Okuhara, Naoki Fukami
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Patent number: 5547934Abstract: The present invention relates to a novel polypeptide having the following presumed structure: ##STR1## and the compound has both excellent fungicidal and protozoicidal effects.Type: GrantFiled: April 27, 1995Date of Patent: August 20, 1996Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Akihiko Fujie, Shigehiro Takase, Michio Yamashita, Tomoko Sato, Seiji Hashimoto, Masakuni Okuhara
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Patent number: 5545542Abstract: WB2663 substance-producing bacteria belonging to the genus Pseudomonas are cultured to produce a physiologically active substance, from which are isolated neutral substances WB2663A, WB2663B and WB2663C having respective specific rotations[.alpha.].sub.D.sup.23 : -36.degree. (C=0.5, CH.sub.2 Cl.sub.2),[.alpha.].sub.D.sup.23 : -12.degree. (C=0.5, CH.sub.2 Cl.sub.2),[.alpha.].sub.D.sup.23 : -9.degree. (C=0.5, CH.sub.2 Cl.sub.2),These substances have an excellent antitumor effect.Type: GrantFiled: March 31, 1995Date of Patent: August 13, 1996Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hidenori Nakajima, Yasuhiro Hori, Toshio Goto, Shigehiro Takase, Koen Verhaeghe, Hiroshi Terano, Masakuni Okuhara
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Patent number: 5447854Abstract: The invention relates to a method of producing cyclosporin A and/or C which is characterized by culturing a cyclosporin A and/or C-producing strain of microorganism belonging to the genus Nectria (e.g. Nectria sp. F-4908) and recovering cyclosporin A and/or C from the resulting cultured broth.Type: GrantFiled: November 10, 1993Date of Patent: September 5, 1995Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Toshio Goto, Toru Kino, Masakuni Okuhara, Hirokazu Tanaka, Yasuhisa Tsurumi, Shigehiro Takase