Abstract: Provided are compounds which are an NMDA antagonist having a broad safety margin and are useful as a treating agent or a preventing agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, pain, etc. Concretely provided are an amine derivative or its salt characterized in that the amine-containing structure A therein bonds to a 2- or 3-cyclic condensed ring (e.g., indane, tetralone, 4,5,6,7-tetrahydrobenzothiophene, 4,5,6,7-tetrahydrobenzofuran, 7,8-dihydro-6H-indeno[4,5-b]furan, 2,3-dihydro-1H-cyclopenta[1]naphthalene) via X1 (bond or lower alkylene); and an NMDA antagonist containing it as an active ingredient thereof.

Abstract: To provide pharmaceutical compositions for suppressing ?-amyloid production on the basis of the cyclin-dependent kinase inhibitory activity. When a substance having a cyclin-dependent kinase inhibitory activity was allowed to contact with nerve cells, the ?-amyloid production was suppressed.

Abstract: An energy-saving, high-outputting and high-efficiency, electric discharge type of illumination apparatus and associated units having thin divisional electrode pieces arranged at relatively narrow intervals on an electrode-application area, which is defined on the bottom of a flat container. The divisional electrode pieces are fixed to the electrode-application area with an intervening sheet of good electrically insulating and thermally conductive material laid therebetween. A front glass having a fluorescence coating on its inside is placed to confront the electrode-application area. Cooling water is circulated in the electrode-application area for cooling the divisional electrode pieces. A multi-poled magnet sheet arranged outside the electrode-application area is aligned with the electrode-to-electrode space. Lower frequency power supplies are connected to the divisional electrodes to supply that with voltages of the same amplitude.

Abstract: An energy-saving, high-outputting and high-efficiency, electric discharging type of illumination apparatus and associated units are provided.

Abstract: To provide pharmaceutical compositions for suppressing &bgr;-amyloid production on the basis of the cyclin-dependent kinase inhibitory activity. When a substance having a cyclin-dependent kinase inhibitory activity was allowed to contact with nerve cells, the &bgr;-amyloid production was suppressed.