Abstract: An object is to prevent roughening of a rupture surface of a packaging material (12) that is formed upon opening of a spout (21) through application of an external force. There are provided transport means for transporting a layered packaging material (12) that is formed of a paper substrate and resin films and that has a rupture area (52) at a location corresponding to that of opening means; a seal unit for sealing the packaging material (12); and heating means disposed on the upstream side of the seal unit in the transport direction of the packaging material (12) such that the heating means is opposed to an innermost layer of the packaging material (12) in order to heat the packaging material (12). In this case, after being heated and melted, the resin film of the packaging material (12) is gradually cooled. As a result, thermoplastic resin that constitutes the resin film is crystallized and becomes brittle.

Abstract: An apparatus for supplying and applying cap bodies (51) to a packaging container includes a gas supplying device (11) which supplies a hydrogen-oxygen gas mixture obtained by electrolyzing water, a burner unit (22) that is connected to the gas supplying device (11) for receiving hydrogen-oxygen gas mixture from the gas supplying device (11) and burning the hydrogen-oxygen gas mixture and a pickup apparatus (80) which transports a cap body (51) to a heating position above the burner unit (22). The burner unit (22) is provided with a plurality of nozzles (31) that are arranged in a pattern that corresponds in shape to the shape of the underside periphery of the cap body (51). A shield plate (57) is positionable above the nozzles (31) to deflect the hydrogen-oxygen gas mixture emitted from the nozzles (31), and an igniter (32) is disposed adjacent one of the nozzles (31), to ignite the mixture emitted from the nozzle (31).

Abstract: A compound represented by formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is provided, which has an excellent antitumor activity.

Abstract: Disclosed is a process for producing a staurosporine derivative represented by Formula (I): Q is defined as in specification: ##STR1## The staurosporine derivative (I-1) possesses selective protein kinase C-inhibitory and cell growth-inhibiting activities, and platelet-increasing activity.

Abstract: Novel DC-89 compounds represented by the general formula: ##STR1## wherein X represents a single bond or --CH.sub.2 --; and when X represents a single bond, Y represents --CH.sub.2 Br or --CH.sub.2 Cl and when X represents --CH.sub.2 --, Y represents Br, are obtained by the present invention. The compounds have antibacterial and anti-tumor activity.

Abstract: A pharmacologically acceptable acid addition salt of DC-52 with 0.5-2.0 equivalent weight of inorganic acid, sulfonic acid, acidic amino acid, citric acid, transaconitic acid, .alpha.-ketoglutaric acid, itaconic acid, malonic acid or ascorbic acid on the basis of DC-52, having the same degree of antitumor activity as DC-52, is superior to DC-52 in stability at powdering or at preservation.

Abstract: A substance designated by us as AX-2 and represented by the formula: ##STR1## This substance is produced by culturing a microorganism of the genus Streptomyces and capable of producing AX-2 in a medium to accumulate AX-2 in the cultured broth and isolating AX-2 therefrom.An anti-tumor composition comprising an effective amount of AX-2 in association with a physiologically acceptable carrier or excipient, which is active against Sarcoma 180.

Abstract: Disclosed is a process for purifying an enzyme contained in a solution such as cell extract liquor or fermentation culture liquor. The crude enzyme solution is brought into contact with either a strongly acidic cation exchange resin of high porous type or a strongly basic anion exchange resin of high porous type to adsorb the enzyme on the resin. An eluting agent is then passed through the resin to elute out the enzyme as a purified enzyme solution.