Abstract: The present invention provides a composition effective in improving symptoms of autism spectrum disorder. The composition contains at least one pyridoxamine compound selected from the group consisting of pyridoxamine and pharmaceutically acceptable salts thereof as an active substance. The composition may be used in combination with at least one thiamine compound selected from the group consisting of thiamine, derivatives thereof, and pharmaceutically acceptable salts thereof.

Abstract: The present invention provides a composition effective in improving symptoms of autism spectrum disorder. The composition contains at least one pyridoxamine compound selected from the group consisting of pyridoxamine and pharmaceutically acceptable salts thereof as an active substance. The composition may be used in combination with at least one thiamine compound selected from the group consisting of thiamine, derivatives thereof, and pharmaceutically acceptable salts thereof.

Abstract: DNA amplification and hybridization are successively carried out in a reaction system containing primers for the DNA amplification and hybridization probes, followed by detecting the hybrid in the reaction solution by affinity chromatography, wherein at least one of the primers to be used in the DNA amplification is labeled with a first labeling agent so that the amplified DNA will be labeled with the first labeling agent, a hybridization probe is labeled with a second labeling agent and contained in a reaction solution for effecting the DNA amplification, the base sequence of the hybridization probe is designed not to inhibit the DNA amplification, and a hybrid is detected by affinity chromatography with the use of the first and second labeling agents.

Abstract: DNA amplification and hybridization are successively carried out in a reaction system containing primers for the DNA amplification and hybridization probes, followed by detecting the hybrid in the reaction solution by affinity chromatography, wherein at least one of the primers to be used in the DNA amplification is labeled with a first labeling agent so that the amplified DNA will be labeled with the first labeling agent, a hybridization probe is labeled with a second labeling agent and contained in a reaction solution for effecting the DNA amplification, the base sequence of the hybridization probe is designed not to inhibit the DNA amplification, and a hybrid is detected by affinity chromatography with the use of the first and second labeling agents.

Abstract: DNA amplification and hybridization are successively carried out in a reaction system containing primers for the DNA amplification and hybridization probes, followed by detecting the hybrid in the reaction solution by affinity chromatography, wherein at least one of the primers to be used in the DNA amplification is labeled with a first labeling agent so that the amplified DNA will be labeled with the first labeling agent, a hybridization probe is labeled with a second labeling agent and contained in a reaction solution for effecting the DNA amplification, the base sequence of the hybridization probe is designed not to inhibit the DNA amplification, and a hybrid is detected by affinity chromatography with the use of the first and second labeling agents.

Abstract: An object is to provide a reactor for hydrotreating which exhibits a total desulfurizing activity higher than that of the reactor according to the prior art, and which is reduced in the rate of lowering of the desulfurizing activity and therefore can keep the high desulfurizing activity over a long period, and to provide a process by the use of the reactor. A reactor for hydrotreating, which comprises at least four catalyst layers packed respectively with hydrotreating catalysts satisfying the relationship represented by the following formulae: Sn≦Sn+1, 1.15Vn≧Vn+1 wherein S represents the surface area per cubic meter of each hydrotreating catalyst; V represents the pore volume per cubic meter of catalyst; and wherein n is a natural number representing the order of each catalyst layer.

Abstract: An object is to provide a reactor for hydrotreating which exhibits a total desulfurizing activity higher than that of the reactor according to the prior art, and which is reduced in the rate of lowering of the desulfurizing activity and therefore can keep the high desulfurizing activity over a long period, and to provide a process by the use of the reactor. A reactor for hydrotreating, which comprises at least four catalyst layers packed respectively with hydrotreating catalysts satisfying the relationship represented by the following formulae: Sn≦Sn+1, 1.15Vn≧Vn+1 wherein S represents the surface area per cubic meter of each hydrotreating catalyst; V represents the pore volume per cubic meter of catalyst; and wherein n is a natural number representing the order of each catalyst layer.

Abstract: A hydrocracking catalyst for hydrocarbon oil, comprising a complex oxide with at least 2 different elements selected from Group 3b, Group 4a, Group 4b and Group 5b of the Periodic Table, zeolite having a solid Al-NMR spectrum wherein the ratio A/B of the peak area A in a chemical shift of -30 to 18 ppm to the peak area B in a chemical shift of 20-100 ppm is 0.01-0.39 and whose surface area of pores of diameter 10 angstrom or smaller constitutes 10-85% of the total surface area, and at least one metal selected from Group 6a and Group 8 of the Periodic Table. Also, a hydrocracking method characterized by hydrocracking of petroleum distillates with a boiling point of 250-600.degree. C. using the hydrocracking catalyst in the presence of hydrogen, under conditions with a reaction temperature of 100-800.degree. C., a reaction pressure of 3-30 MPa, an LHSV of 0.01-10 h.sup.-1 and a hydrogen/oil ratio of 100-2500 Nm.sup.3 /m.sup.3.