Patents by Inventor Shigeru Hiramoto
Shigeru Hiramoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10538793Abstract: Provided is ?3 desaturase having high enzymatic activity even at normal temperature. A polypeptide which consists of an amino acid sequence having an identity of 80% or more with the amino acid sequence represented by SEQ ID NO: 2 and has ?3 desaturation activity on C20 fatty acid, and a gene thereof.Type: GrantFiled: December 24, 2015Date of Patent: January 21, 2020Assignees: KYOTO UNIVERSITY, NISSHIN PHARMA INC.Inventors: Jun Ogawa, Akinori Ando, Eiji Sakuradani, Sakayu Shimizu, Shigeru Hiramoto, Masataka Harata, Yuki Takemoto
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Publication number: 20170369909Abstract: Provided is ?3 desaturase having high enzymatic activity even at normal temperature. A polypeptide which consists of an amino acid sequence having an identity of 80% or more with the amino acid sequence represented by SEQ ID NO: 2 and has ?3 desaturation activity on C20 fatty acid, and a gene thereof.Type: ApplicationFiled: December 24, 2015Publication date: December 28, 2017Applicants: KYOTO UNIVERSITY, NISSHIN PHARMA INC.Inventors: Jun OGAWA, Akinori ANDO, Eiji SAKURADANI, Sakayu SHIMIZU, Shigeru HIRAMOTO, Masataka HARATA, Yuki TAKEMOTO
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Publication number: 20160208297Abstract: Provided is an ?3 desaturase having a high enzymatic activity even at normal temperature. A polypeptide consisting of an amino acid sequence having an identity of 80% or more with the amino acid sequence represented by SEQ ID NO: 2 and having ?3 desaturation activity, and a gene therefor.Type: ApplicationFiled: August 26, 2014Publication date: July 21, 2016Applicants: KYOTO UNIVERSITY, NISSHIN PHARMA INC.Inventors: Jun OGAWA, Eiji SAKURADANI, Akinori ANDO, Sakayu SHIMIZU, Masataka HARATA, Shigeru HIRAMOTO
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Publication number: 20100173025Abstract: The present invention provides a composition that exhibits favorable fat absorption inhibitory activity, is capable of being safely and easily taken continuously without side effects, and further is capable of preventing and/or improving conditions associated with excessive fat absorption such as obesity and hyperlipidemia. The present invention relates to a fat absorption inhibitory composition, which contains as an active ingredient a component that is collected as insoluble matter obtained by extracting wheat germ with water at 65° C. or lower and pH 5.0 or lower and treating the extract at 70° C. or higher and pH 6.0 or higher.Type: ApplicationFiled: September 4, 2008Publication date: July 8, 2010Applicant: NISSHIN PHARMA INC.Inventors: Yuki Katayanagi, Shigeru Hiramoto
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Publication number: 20100120667Abstract: A composition for effectively preventing or treating peptic ulcers not caused by Helicobacter pylori that does not cause any adverse reaction and thus is highly safe is provided. The present invention relates to a composition for preventing and/or treating peptic ulcers not caused by Helicobacter pylori, which comprises as an active ingredient a browning reaction product of a sugar and a protein.Type: ApplicationFiled: April 25, 2008Publication date: May 13, 2010Applicant: NISSHIN PHARMA INC.Inventors: Masao Nagase, Shigeru Hiramoto, Masataka Harata, Yoshio Suzuki
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Patent number: 7022732Abstract: This invention relates to a medicament containing as an active ingredient, a novel propanolamine having a 1,4-benzodioxane ring or a pharmaceutically acceptable salt thereof: The present compound is represented by the above formula wherein R1-3 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxy group, a (C1–C6)alkyl group, a (C1–C6)alkoxy group, a (C1–C6)alkylsulfonamido group, or a phenyl group; R4-5 each represents a hydrogen atom or a (C1–C6)alkyl group; and A represents any of a benzene ring, a pyridine ring and a pyrimidine ring. This compound is useful as a prophylactic or therapeutic agent for diabetes, obesity, hyperlipemia, depression, a respiratory disease, or a gastrointestinal disease.Type: GrantFiled: September 13, 2001Date of Patent: April 4, 2006Assignees: Nisshin Pharma Inc., Kyorin Pharmaceutical Co., Ltd.Inventors: Masahiro Ueno, Koji Kawamura, Makoto Yanai, Toshihiro Takahashi, Nobuhiro Kinoshita, Koichi Katsuyama, Satoko Fuchizawa, Shigeru Hiramoto
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Publication number: 20050096262Abstract: This invention relates to a Helicobacter pylori adhesion inhibitor that is capable of eliminating Helicobacter pylori associated with the development of peptic ulcer from the stomach, a method for producing the same, and pharmaceutical compositions and foods for preventing or treating diseases associated with Helicobacter pylori comprising such Helicobacter pylori adhesion inhibitor. The inhibitor of the present invention has excellent activity of eradicating Helicobacter pylori and is highly safe. Accordingly, pharmaceutical compositions and foods comprising the same are highly useful for the prevention or treatment of the aforementioned diseases.Type: ApplicationFiled: January 27, 2003Publication date: May 5, 2005Inventors: Shigeru Hiramoto, Yoshiro Morishita, Nobutake Kimura, Yoshikatsu Kodama
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Patent number: 6858585Abstract: Cyclic depsipeptides represented by the formula wherein: R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15-carbon atoms; A, B, D, E and F independently each other are alanine, valine, leucine, isoleucine, phenylalanine, etc.; W and Z independently each other are aspartic acid, asparagine, glutamic acid or glutamine; and m and n independently each other is 0 or 1, or pharmacologically acceptable salts thereof. The present compounds are prepared according to a method conventionally used in peptide synthesis. The present compounds are useful as an agent for promoting the production of apolipoprotein E, a therapeutic agent for neurologic damages, a therapeutic agent for dementia, an agent for inhibiting the production of apolipoprotein B, an agent for promoting the production of apolipoprotein A1 or a therapeutic agent for hyperlipemia.Type: GrantFiled: June 25, 1997Date of Patent: February 22, 2005Assignee: Nisshin Seifun Group Inc.Inventors: Makoto Yanai, Masashi Suzuki, Norio Oshida, Koji Kawamura, Shigeru Hiramoto, Orie Yasuda, Nobuhiro Kinoshita, Akiko Shingai, Masako Takasu
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Publication number: 20040235921Abstract: This invention relates to a medicament containing as an active ingredient, a novel propanolamine having a 1,4-benzodioxane ring or a pharmaceutically acceptable salt thereof: 1Type: ApplicationFiled: April 21, 2004Publication date: November 25, 2004Inventors: Masahiro Ueno, Koji Kawamura, Makoto Yanai, Toshihiro Takahashi, Nobuhiro Kinoshita, Koichi Katsuyama, Satoko Fuchizawa, Shigeru Hiramoto
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Patent number: 6316406Abstract: A depsipeptide containing N-substituted glycine residue having the formula (1) or (2): (wherein R1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R2 is a group of the formula —A—B—W—(D)m—(E)n, —A—B—W—(D)m—(E)n—F or —A—B—W—(D)m—(E)n—F—Z; R3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, or a group of the formula —Z, —Z—G or —Z—G—J; A, B, D, E, F, G and J independently are an N-substituted glycine residue or a residue of an amino acid selected from the group consisting of alanine, valine, leucine, serine, etc.; W and Z independently are a residue of an amino acid selected from the group consisting of an aspartic acid, a glutamic acid, etc.Type: GrantFiled: August 24, 1999Date of Patent: November 13, 2001Assignee: Nisshin Seifun Group Inc.Inventors: Makoto Yanai, Masashi Suzuki, Norio Oshida, Koji Kawamura, Shigeru Hiramoto, Orie Yasuda, Nobuhiro Kinoshita, Akiko Shingai, Masako Takasu
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Patent number: 6288038Abstract: The present invention provides a new depsipeptide derivative having a piperazinone ring within the molecule which is represented by formula (1) wherein X1 represents N(R4)—CO, N(R5)—CH2, CH2—CO, CH2—CH2, CH═CH, CH2—CH(OH) or CH(OH)—CH(OH), R1 represents a C5-C20 alkyl group or a C5-C15 alkoxy C1-C4 alkyl group, R2-R5 represent a hydrogen atom or a C1-C6 alkyl group, and A represents a group of formula (2), (3) or (4) The depsipeptide derivative has a function of accelerating the production of apolipoprotein E and is useful as an agent for the treatment of neurologic injury, an agent for the treatment of dementia and an antihyperlipidemic agent.Type: GrantFiled: April 3, 2000Date of Patent: September 11, 2001Assignee: Nisshin Seifun Group Inc.Inventors: Makoto Yanai, Masashi Suzuki, Norio Oshida, Koji Kawamura, Shigeru Hiramoto, Orie Yasuda, Nobuhiro Kinoshita, Akiko Shingai, Masako Takasu
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Patent number: 6255286Abstract: Depsipeptides represented by the formula (1): (wherein: R1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R2 is —A—B, —A—B—W, —A—B—W—D or —A—B—W—D—E, R3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, —Z, —Z—G or —Z—G—J, the above A, B, D, E, G and J independently each other are a residue of an amino acid selected from alanine, valine, leucine, isoleucine, serine, threonine, lysine, hydroxylysine, arginine, cysteine, methionine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamic acid, glutamine and the like or an N—(C1-C4) alkyl derivative of these amino acid residues; the above W and Z independently each other are a residue of an amino acid selected from aspartic acid, asparagine, glutamic acid, glutamine, alanine, serine or lysine) or pharmacologically acceptableType: GrantFiled: December 24, 1998Date of Patent: July 3, 2001Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Makoto Yanai, Masashi Suzuki, Norio Oshida, Koji Kawamura, Shigeru Hiramoto, Orie Yasuda, Nobuhiro Kinoshita, Akiko Shingai, Masako Takasu
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Patent number: 6252041Abstract: A depsipeptide containing a non-natural amino acid(s) having the formula (1) wherein R1 represents a C5-C20 alkyl group and others; R2 represents —O—CO—CH(R5)—X—CH(R6)—NH— (wherein X represents N(R7)—CO, CH2—CO, CH2—CH2 and others, R5, R6, and R7 represent a hydrogen atom or a C1-C6 alkyl group); R3 represents and wherein the remaining substituent variables are as defined herein. The above depsipeptides have a promoting activity on the production of apolipoprotein E, and are useful as a therapeutic agent for neurologic damages, especially dementia, and hyperlipemia.Type: GrantFiled: January 22, 1999Date of Patent: June 26, 2001Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Makoto Yanai, Masashi Suzuki, Norio Oshida, Koji Kawamura, Shigeru Hiramoto, Orie Yasuda, Nobuhiro Kinoshita, Akiko Shingai, Masako Takasu
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Patent number: 6211145Abstract: The present invention provides a bicyclic depsipeptide having the formula (1) wherein: R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; A, D, E and J independently are a residue of an amino acid selected from the group of alanine, valine, leucine, etc.; B and F are the same or different and a residue of an amino acid selected from the group consisting of cysteine, aspartic acid, glutamic acid, lysine, hydroxylysine and serine; G is a disulfide bond, an amido bond or an ester bond; W is a residue of an amino acid selected from the group consisting of aspartic acid and glutamic acid; Z is a residue of an amino acid selected from the group consisting of aspartic acid, asparagine, glutamic acid and glutamine; l, m, n, p and q independently are 0 or 1; or a pharmacologically acceptable salt thereof.Type: GrantFiled: December 16, 1998Date of Patent: April 3, 2001Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Makoto Yanai, Masashi Suzuki, Norio Oshida, Koji Kawamura, Shigeru Hiramoto, Orie Yasuda, Nobuhiro Kinoshita, Akiko Shingai, Masako Takasu
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Patent number: 6001815Abstract: A depsipeptide containing N-substituted glycine residue having the formula (1) or (2): ##STR1## (wherein R.sub.1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R.sub.2 is a group of the formula --A--B--W--(D).sub.m --(E).sub.n, --A--B--W--(D).sub.m --(E).sub.n --F or --A--B--W--(D).sub.m --(E).sub.n --F--Z; R.sub.3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, or a group of the formula --Z, --Z--G or --Z--G--J; A, B, D, E, F, G and J independently are an N-substituted glycine residue or a residue of an amino acid selected from the group consisting of alanine, valine, leucine, serine, etc.; W and Z independently are a residue of an amino acid selected from the group consisting of an aspartic acid, a glutamic acid, etc.; at least one of A, B, D, E, F, G and J is an N-substituted glycine residue) or a pharmacologically acceptable salt thereof.Type: GrantFiled: December 21, 1998Date of Patent: December 14, 1999Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Makoto Yanai, Masashi Suzuki, Norio Oshida, Koji Kawamura, Shigeru Hiramoto, Orie Yasuda, Nobuhiro Kinoshita, Akiko Shingai, Masako Takasu
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Patent number: 5801143Abstract: A cyclic depsipeptide having the general formula (I) ##STR1## (wherein n is an integer of 5-15) or a pharmacologically acceptable salt thereof. The present compound can be prepared by cultivation of a cyclic depsipeptide-producing microorganism belonging to the genus of Bacillus. The present compounds are useful as a therapeutic agent for hyperlipemia, an agent for inhibiting the secretion of lipids or an agent for inhibiting the production of apolipoprotein B.Type: GrantFiled: November 25, 1996Date of Patent: September 1, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Shigeru Hiramoto, Yukio Saito, Shigeo Hatanaka, Akiko Shingai
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Patent number: 5621010Abstract: Urea derivatives of formula (I) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.Type: GrantFiled: May 18, 1994Date of Patent: April 15, 1997Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Noriyoshi Sueda, Kazuhiko Yamada, Makoto Yanai, Katsutoshi Miura, Masato Horigome, Norio Oshida, Shigeru Hiramoto, Koichi Katsuyama, Fumihisa Nakata, Nobuhiro Kinoshita, Yoko Tsukada
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Patent number: 5576335Abstract: Urea derivatives of formula (1) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.Type: GrantFiled: September 29, 1994Date of Patent: November 19, 1996Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Noriyoshi Sueda, Kazuhiko Yamada, Makoto Yanai, Katsutoshi Miura, Masato Horigome, Norio Oshida, Shigeru Hiramoto, Koichi Katasuyama, Fumihisa Nakata, Nobuhiro Kinoshita, Yoko Tsukada
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Patent number: 4649135Abstract: Mycotrienin-related compounds called the T-23-X, -XI, -XII, -XIII and -XIV. These compounds are isolated and characterized by structural formula and other identifying data. They are useful in the treatment of tumors.Type: GrantFiled: April 15, 1986Date of Patent: March 10, 1987Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Noboru Otake, Haruo Seto, Tetsuo Sasaki, Masanori Sugita, Shigeru Hiramoto
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Patent number: 4587237Abstract: Mycotrienin-related compounds called the T-23-VIII and T-23-IX substances. These substances are isolated and characterized by structural formula and other identifying data. These substances are useful in the treatment of tumors.Type: GrantFiled: September 6, 1985Date of Patent: May 6, 1986Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Noboru Otake, Haruo Seto, Tetsuo Sasaki, Masanori Sugita, Shigeru Hiramoto