Patents by Inventor Shigeru Moriwaki
Shigeru Moriwaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9341618Abstract: The present invention provides a method for evaluating or screening a hair growth-regulating agent which utilizes a readily available animal. The present invention is directed to a method for evaluating or screening a hair growth-regulating agent which comprises subjecting hair follicles of a pig to an organ culture in the presence of a test substance, and evaluating or selecting a substance which promotes or suppresses the growth of the hair follicles.Type: GrantFiled: February 19, 2008Date of Patent: May 17, 2016Assignee: Kao CorporationInventors: Michiyo Sasajima, Noriko Ito, Shigeru Moriwaki, Chie Fuse
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Patent number: 9222079Abstract: A method of increasing expression of the aromatase gene by treating a cell population with an effective amount of an aromatase activator containing an extract of Iris florentina, where the effective amount ranges from 0.0001 to 1% by weight based on the total weight of the aromatase activator on a dry basis.Type: GrantFiled: December 16, 2010Date of Patent: December 29, 2015Assignee: KAO CORPORATIONInventors: Shingo Kakuo, Shigeru Moriwaki, Atsushi Ohuchi, Hiroshi Kusuoku
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Patent number: 8808758Abstract: To provide a drug, an external use composition, and a cosmetic composition, which exhibit an NFAT signal inhibitory action, a calcineurin inhibitory action, and a hair growth-promoting effect. The NFAT signal inhibitor contains, as an active ingredient, American angelica or an extract thereof.Type: GrantFiled: June 20, 2013Date of Patent: August 19, 2014Assignee: Kao CorporationInventors: Azumi Nagasawa, Shigeru Moriwaki, Mitsuyoshi Sakasai, Megumi Matsuoka, Michiyo Sasajima, Noriko Ito
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Publication number: 20130260457Abstract: To provide a drug, an external use composition, and a cosmetic composition, which exhibit an NFAT signal inhibitory action, a calcineurin inhibitory action, and a hair growth promoting effect. The NFAT signal inhibitor contains, as an active ingredient, American angelica or an extract thereof.Type: ApplicationFiled: June 20, 2013Publication date: October 3, 2013Inventors: Azumi NAGASAWA, Shigeru Moriwaki, Mitsuyoshi Sakasai, Megumi Matsuoka, Michiyo Sasajima, Noriko Ito
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Patent number: 8470376Abstract: To provide a drug, an external use composition, and a cosmetic composition, which exhibit an NFAT signal inhibitory action, a calcineurin inhibitory action, and a hair growth-promoting effect. The NFAT signal inhibitor contains, as an active ingredient, American angelica or an extract thereof.Type: GrantFiled: June 15, 2009Date of Patent: June 25, 2013Assignee: Kao CorporationInventors: Azumi Nagasawa, Shigeru Moriwaki, Mitsuyoshi Sakasai, Megumi Matsuoka, Michiyo Sasajima, Noriko Ito
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Patent number: 8282946Abstract: Provided are a water-soluble ginger root extract which is a water extract or a hydrous alcohol extract of a ginger root and is substantially free of gingerols; and a hair growth inhibitor and a preparation for external use each containing the extract. The water-soluble ginger root extract of the present invention causes less skin irritation because of being substantially free of gingerols, and has excellent body-hair growth inhibiting effects, so that it is useful as a hair grown inhibitor and a preparation for external use, each having a high degree of safety.Type: GrantFiled: October 11, 2005Date of Patent: October 9, 2012Assignee: Kao CorporaionInventors: Yusuke Shibuya, Shigeru Moriwaki, Naoko Tsuji
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Publication number: 20120087995Abstract: To provide a drug, an external use composition, and a cosmetic composition, which exhibit an NFAT signal inhibitory action, a calcineurin inhibitory action, and a hair growth-promoting effect. The NFAT signal inhibitor contains, as an active ingredient, American angelica or an extract thereof.Type: ApplicationFiled: June 15, 2009Publication date: April 12, 2012Inventors: Azumi Nagasawa, Shigeru Moriwaki, Mitsuyoshi Sakasai, Megumi Matsuoka, Michiyo Sasajima, Noriko Ito
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Publication number: 20110151036Abstract: A method of increasing expression of the aromatase gene by treating a cell population with an effective amount of an aromatase activator containing an extract of Iris florentina, where the effective amount ranges from 0.0001 to 1% by weight based on the total weight of the aromatase activator on a dry basis.Type: ApplicationFiled: December 16, 2010Publication date: June 23, 2011Inventors: Shingo KAKUO, Shigeru Moriwaki, Atsushi Ohuchi, Hiroshi Kusuoku
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Patent number: 7887851Abstract: Drugs and cosmetics which are highly safe, and which are effective in preventing, improving, or treating various pathological conditions caused by estrogen depletion are provided. Provided are aromatase activators containing at least one member selected from plants such as Labiatae sps. including Isodon, Scutellaria (huangcen), Schizonepeta (jingjie), sage, lavender, Lamium album, and thyme, an extract thereof; yeast extract; silk protein extract; milk protein; trehalose; natto extract; royal jelly; oryza oil; hydrolyzated wheat extract; shea butter; and rice fermentation extract.Type: GrantFiled: June 1, 2005Date of Patent: February 15, 2011Assignee: Kao CorporationInventors: Shingo Kakuo, Shigeru Moriwaki, Atsushi Ohuchi, Hiroshi Kusuoku
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Publication number: 20100189709Abstract: An elastase inhibitor containing, as an active ingredient, a protein hydrolysate (with soybean protein hydrolysate and almond protein hydrolysate being excluded). Pharmaceuticals and cosmetics containing such an elastase inhibitor which exhibit an inhibitory effect against the growth of body hair, and skin aging preventing effect by restoring elasticity and tonicity of the skin and reducing wrinkles.Type: ApplicationFiled: April 2, 2010Publication date: July 29, 2010Applicant: Kao CorporationInventors: Shigeru Moriwaki, Naoko Morisaki, Christine Hall
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Publication number: 20080206806Abstract: The present invention provides a method for evaluating or screening a hair growth-regulating agent which utilizes a readily available animal. The present invention is directed to a method for evaluating or screening a hair growth-regulating agent which comprises subjecting hair follicles of a pig to an organ culture in the presence of a test substance, and evaluating or selecting a substance which promotes or suppresses the growth of the hair follicles.Type: ApplicationFiled: February 19, 2008Publication date: August 28, 2008Inventors: Michiyo SASAJIMA, Noriko Ito, Shigeru Moriwaki, Chie Fuse
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Publication number: 20070116659Abstract: The present invention relates to an elastase inhibitor containing, as an active ingredient, a protein hydrolysate (with soybean protein hydrolysate and almond protein hydrolysate being excluded). According to the present invention, there can be provided pharmaceuticals and cosmetics which exhibit inhibitory effect against the growth of body hair, and skin aging preventing effect by restoring elasticity and tonicity of the skin and reducing wrinkles.Type: ApplicationFiled: January 26, 2007Publication date: May 24, 2007Applicant: Kao CorporationInventors: Shigeru MORIWAKI, Naoko Morisaki, Christine Hall
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Patent number: 7211278Abstract: treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.Type: GrantFiled: February 13, 2004Date of Patent: May 1, 2007Assignee: Kao CorporationInventors: Naoko Tsuji, Shigeru Moriwaki, Atsushi Ohuchi, Yasuto Suzuki
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Patent number: 7189708Abstract: A topical skin composition containing a dipeptide compound represented by formula (1) or a salt of the dipeptide: wherein R1 represents a hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and a pharmaceutically acceptable carrierType: GrantFiled: September 23, 2002Date of Patent: March 13, 2007Assignee: Kao CorporationInventors: Yasuto Suzuki, Mikako Watanabe, Naoko Tsuji, Shigeru Moriwaki, Shinya Amano
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Publication number: 20070041996Abstract: The present invention is directed to an aromatase activating agent containing a plant selected from among mulberry bark, ginseng, cucumber, and phellodendron bark; or chlorella; or an extract of any of these ingredients. The aromatase activating agent of the present invention is highly safe to the human body, and useful as a drug or cosmetic composition for prevention, amelioration, or treatment of various lesions caused by estrogen deficiency.Type: ApplicationFiled: October 13, 2006Publication date: February 22, 2007Applicant: KAO CORPORATIONInventors: Shingo Kakuo, Shigeru Moriwaki, Atsushi Ohuchi, Hiroshi Kusuoku
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Patent number: 7147877Abstract: The present invention is directed to an aromatase activating agent containing a plant selected from among mulberry bark, ginseng, cucumber, and phellodendron bark; or chlorella; or an extract of any of these ingredients. The aromatase activating agent of the present invention is highly safe to the human body, and useful as a drug or cosmetic composition for prevention, amelioration, or treatment of various lesions caused by estrogen deficiency.Type: GrantFiled: December 3, 2003Date of Patent: December 12, 2006Assignee: Kao CorporationInventors: Shingo Kakuo, Shigeru Moriwaki, Atsushi Ohuchi, Hiroshi Kusuoku
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Publication number: 20060127412Abstract: Drugs and cosmetics which are highly safe, and which are effective in preventing, improving, or treating various pathological conditions caused by estrogen depletion are provided. Provided are aromatase activators containing at least one member selected from plants such as Labiatae sps. including Isodon, Scutellaria (huangcen), Schizonepeta (jingjie), sage, lavender, Lamium album, and thyme, an extract thereof; yeast extract; silk protein extract; milk protein; trehalose; natto extract; royal jelly; oryza oil; hydrolyzated wheat extract; shea butter; and rice fermentation extract.Type: ApplicationFiled: June 1, 2005Publication date: June 15, 2006Applicant: KAO CORPORATIONInventors: Shingo Kakuo, Shigeru Moriwaki, Atsushi Ohuchi, Hiroshi Kusuoku
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Patent number: 7056499Abstract: The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.Type: GrantFiled: February 8, 2002Date of Patent: June 6, 2006Assignee: Kao CorporationInventors: Naoko Tsuji, Shigeru Moriwaki, Atsushi Ohuchi, Yasuto Suzuki
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Publication number: 20060099280Abstract: Provided are a water-soluble ginger root extract which is a water extract or a hydrous alcohol extract of a ginger root and is substantially free of gingerols; and a hair growth inhibitor and a preparation for external use each containing the extract. The water-soluble ginger root extract of the present invention causes less skin irritation because of being substantially free of gingerols, and has excellent body-hair growth inhibiting effects, so that it is useful as a hair grown inhibitor and a preparation for external use, each having a high degree of safety.Type: ApplicationFiled: October 11, 2005Publication date: May 11, 2006Applicant: Kao CorporationInventors: Yusuke Shibuya, Shigeru Moriwaki, Naoko Tsuji
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Patent number: 7041658Abstract: Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.Type: GrantFiled: March 16, 2004Date of Patent: May 9, 2006Assignee: Kao CorporationInventors: Naoko Tsuji, Shigeru Moriwaki, Atsushi Ohuchi, Yoshinori Takema, Yasuto Suzuki, Genji Imokawa