Patents by Inventor Shigeru Torii
Shigeru Torii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090165653Abstract: To provide an apparatus for gasifying and separating a liquid medium, which is of an automatic type and which can be increased in size.Type: ApplicationFiled: December 15, 2006Publication date: July 2, 2009Applicant: Techno Sigma Co., Ltd.Inventors: Shigeru Torii, Kouichi Miki, Katsumi Koretomo
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Patent number: 5919924Abstract: A process for preparing a 3-halogenated cephem derivative represented by the formula (2), characterized by causing a halogenating reagent to act on an allenyl .beta.-lactam compound represented by the formula (1) in the presence of a cuprous salt or cupric salt to obtain the 3-halogenated cephem derivative ##STR1## wherein R.sup.1 is a hydrogen atom, amino or protected amino, R.sup.2 is a hydrogen atom, halogen atom, lower alkoxyl, lower acyl, lower alkyl, lower alkyl having at least one selected from hydroxyl and protected hydroxyl as a substituent, hydroxyl or protected hydroxyl, R.sup.3 is a hydrogen atom or carboxylic acid protecting group, R.sup.4 is an aromatic compound residue which may have a substituent or nitrogen-containing aromatic heterocyclic compound residue which may have a substituent, and n is 0 to 2 ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, X is a halogen atom.Type: GrantFiled: June 3, 1997Date of Patent: July 6, 1999Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Michio Sasaoka, Shigeru Torii, Hideo Tanaka, Ryo Kikuchi, Yutaka Kameyama, Kouichi Sorajo
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Patent number: 5693792Abstract: The object of the invention is to provide a .beta.-lactam compound and a 2-substituted methyl-3-cephem compound, both of which are of value as intermediates for the synthesis of cephem antibiotics.The .beta.-lactam compound of the invention may be represented by the general formula ##STR1## wherein R.sup.1 represents a protected amino group, for instance; R.sup.2 represents hydrogen, for instance; R.sup.3 represents hydrogen or a carboxy-protecting group; R.sup.4 represents an aryl group which may be substituted; R.sup.5 represents an alkenyl group which may be substituted, for instance. The 2-substituted methyl-3-cephem compound of the invention may be represented by the general formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above; R.sup.6 represents an aryl group which may be substituted.Type: GrantFiled: August 15, 1995Date of Patent: December 2, 1997Assignee: Otsuga Kagaku Kabushiki KaishaInventors: Shigeru Torii, Hideo Tanaka, Mitio Sasaoka, Takashi Shiroi, Yutaka Kameyama
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Patent number: 5656754Abstract: The present invention provides a process for preparing a cephem compound represented by the general formula (3) characterized in that an allenyl-.beta.-lactam compound represented by the general formula (1) is reacted with an organotin compound represented by the general formula (2) in the presence of a monovalent copper salt ##STR1## wherein R.sup.1 is a hydrogen atom, halogen atom, amino or protected amino, R.sup.2 is a hydrogen atom, halogen atom, lower alkoxyl, lower acyl, lower alkyl, lower alkyl having hydroxyl or protected hydroxyl as a substituent, hydroxyl or protected hydroxyl, or R.sup.1 and R.sup.2 form=0 when taken together, R.sup.3 is a hydrogen atom or carboxylic acid protecting group, R.sup.4 is aryl, aryl having a substituent, nitrogen-containing aromatic heterocyclic group or nitrogen-containing aromatic heterocyclic group having a substituent, and m is 0 or 2,(R.sup.5).sub.n --Sn(R.sup.6).sub.4--n (2)wherein R.sup.Type: GrantFiled: March 22, 1994Date of Patent: August 12, 1997Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Shigeru Torii, Hideo Tanaka, Michio Sasaoka, Takashi Shiroi, Yutaka Kameyama
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Patent number: 5656755Abstract: An object of the invention is to provide a process for preparing a 3-substituted cephem compound from an allenyl-.beta.-lactam compound which can be easily produced from an inexpensive penicillin compound by a simple reaction procedure.The process of the invention comprises reacting an allenyl-.beta.-lactam compound with an organohalogen compound in the presence of a metal having a standard oxidation-reduction potential of -0.3 (V/SCE) or less in an amount at least equimolar with the allenyl-.beta.-lactam compound and 0.0001 to 0.5 mole, per mole of the allenyl-.beta.-lactam compound, of a metal compound having a higher standard oxidation-reduction potential than said metal.Type: GrantFiled: July 6, 1995Date of Patent: August 12, 1997Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Shigeru Torii, Hideo Tanaka, Michio Sasaoka, Takashi Shiroi
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Patent number: 5599925Abstract: A penam derivative of the general formula ##STR1## wherein R.sup.1 means hydrogen, halogen, amino or protected amino; R.sup.2 means hydrogen, halogen, lower alkoxy, lower acyl, lower alkyl, hydroxy- or protected hydroxy-substituted lower alkyl, hydroxy or protected hydroxy, or R.sup.1 and R.sup.2 may jointly represent oxo; R.sup.3 means hydrogen or a carboxy-protecting group; R.sup.4 means hydrogen; R.sup.5 means a group of the formula --CH.sub.2 Y where Y means halogen, --N.sub.3, --ONO.sub.2, --OR.sup.6, --OCOR.sup.6, --SCSOR.sup.6, --SCSN(R.sup.6).sub.2, --SR.sup.6, --SO.sub.2 R.sup.6, --NHR.sup.6, --N(R.sup.6).sub.2 or a substituted or unsubstituted nitrogen-containing heterocyclic group having a free valence on nitrogen; R.sup.6 means a lower alkyl, aryl or heterocyclic group which is substituted or unsubstituted; or R.sup.4 and R.sup.5 may jointly represent .dbd.CH.sub.2 ; n means 0, 1 or 2; provided, however, that where R.sup.4 and R.sup.5 jointly represent .dbd.CH.sub.2, n is not equal to 0.Type: GrantFiled: September 30, 1994Date of Patent: February 4, 1997Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Shigeru Torii, Hideo Tanaka, Masatoshi Taniguchi, Mitio Sasaoka, Takashi Shiroi, Yutaka Kameyama
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Patent number: 5470972Abstract: The object of the invention is to provide a .beta.-lactam compound and a 2-substituted methyl-3-cephem compound, both of which are of value as intermediates for the synthesis of cephem antibiotics.The .beta.-lactam compound of the invention may be represented by the general formula ##STR1## wherein R.sup.1 represents a protected amino group, for instance; R.sup.2 represents hydrogen for instance; R.sup.3 represents hydrogen or a carboxy-protecting group; R.sup.4 represents an aryl group which may be substituted; R.sup.5 represents an alkenyl group which may be substituted, for instance. The 2-substituted methyl-3-cephem compound of the invention may be represented by the general formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above; R.sup.6 represents an aryl group which may be substituted.Type: GrantFiled: October 14, 1993Date of Patent: November 28, 1995Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Shigeru Torii, Hideo Tanaka, Mitio Sasaoka, Takashi Shiroi, Yutaka Kameyama
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Patent number: 4912213Abstract: The present invention provides a process for preparing a penicillanic acid derivative of the formula ##STR1## which comprises reacting lead with a halogenated penicillanic acid derivative of the formula ##STR2## wherein X, Y, Z and R.sup.1 are as defined in the specification. The reaction is advantageously conducted in the presence of a metal having higher ionization tendency than lead such as aluminum, iron, magnesium or a mixture thereof.Type: GrantFiled: September 7, 1988Date of Patent: March 27, 1990Assignees: Otsuka Kagaku Kabushiki Kaisha, Taiho Pharmaceutical Company, LimitedInventors: Masatoshi Taniguchi, Michio Sasaoka, Kiyotoshi Matsumura, Ichiro Kawahara, Kenji Kase, Daisuke Suzuki, Shigeru Torii, Hideo Tanaka, Motoaki Tanaka, Akira Nakai
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Patent number: 4886891Abstract: The present invention provides a process for preparing a 1,1-disubstituted ethylene derivative of the formula ##STR1## which comprises reacting lead with a carbinol derivative of the formula ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, X, Y, m and n are defined in the specification. The reaction is conducted more advantageously in the presence of a metal having higher ionization tendency than lead.Type: GrantFiled: December 18, 1987Date of Patent: December 12, 1989Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Shigeru Torii, Masatoshi Taniguchi, Michio Sasaoka, Yoshihisa Tomotaki, Mitsuo Akada, Hideo Tanaka, Akira Suzuki, Shiro Yamashita
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Patent number: 4808712Abstract: A process for preparing cephalosporin compounds represented by the formula ##STR1## wherein R.sup.1 represents an alkyl group, alkenyl group, substituted or unsubstituted aryl group, substituted or unsubstituted arylmethyl group or substituted or unsubstituted phenoxymethyl group, R.sup.2 represents a carboxyl group or protected carboxyl group, and Y represents the residue of a nucleophilic reagent.Type: GrantFiled: October 14, 1986Date of Patent: February 28, 1989Assignee: Otsuka Kagaku Kabushiki KaishaInventor: Shigeru Torii
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Patent number: 4665166Abstract: A process for preparing cephalosporin compounds represented by the formula ##STR1## wherein R.sup.1 represents an alkyl group, alkenyl group, substituted or unsubstituted aryl group, substituted or unsubstituted arylmethyl group or substituted or unsubstituted phenoxymethyl group, R.sup.2 represents a carboxyl group or protected carboxyl group, and Y represents the residue of a nucleophilic reagent.Type: GrantFiled: May 1, 1984Date of Patent: May 12, 1987Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Shigeru Torii, Hideo Tanaka, Junzo Nogami, Michio Sasaoka, Norio Saito, Takashi Shiroi
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Patent number: 4656264Abstract: An azetidinone compound represented by the formula ##STR1## wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a carboxyl-protecting group, X represents a hydrogen atom or chlorine atom and Y represents --I, --ONO.sub.2, --OH, ##STR2## or --SR.sup.4 in which R.sup.3 is a lower alkyl group or --OR.sup.5 (wherein R.sup.5 is a halogen-containing lower alkyl group) and R.sup.4 is a substituted or unsubstituted, 5-membered aromatic heterocyclic residue containing sulphur and/or nitrogen atom or atoms.Type: GrantFiled: April 29, 1986Date of Patent: April 7, 1987Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Shigeru Torii, Hideo Tanaka, Junzo Nogami, Michio Sasaoka, Norio Saito, Takashi Shiroi
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Patent number: 4622178Abstract: A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R.sup.1 represents a straight-chain or branched-chain lower alkyl group, substituted or unsubstituted aryl group, substituted or unsubstituted phenylmethyl group or substituted or unsubstituted phenyloxymethyl group, R.sup.2 represents hydrogen atom, an optionally substituted hydrocarbon residue or protective group for amino group selected from the class consisting of acyl, silyl, sulfonyl and phosphonyl derived from organic or inorganic acid, and R.sup.3 represents a substituted or unsubstituted aryl group or the residue of substituted or unsubstituted heterocyclic ring.Type: GrantFiled: May 1, 1984Date of Patent: November 11, 1986Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Shigeru Torii, Hideo Tanaka, Junzo Nogami, Michio Sasaoka, Norio Saito, Takashi Shiroi
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Patent number: 4604457Abstract: A 2-substituted cephem derivative represented by the formula ##STR1## wherein R.sup.1 represents a substituted or unsubstituted phenyl group, substituted or unsubstituted phenylmethyl group or substituted or unsubstituted phenoxymethyl group, R.sup.2 represents hydrogen atom or protective group for carboxylic acid and Y represents allyloxy group, benzyloxy group, alkylthio group, carboxyalkylthio group or group of the formula ##STR2## wherein R.sup.4 represents hydrogen atom or lower alkyl group, X represents --O--, --S-- or ##STR3## R.sup.5 represents hydrogen atom, a lower alkyl group or phenyl group and R.sup.6 represents hydrogen atom or lower alkyl group, and a process for preparing the derivatives.Type: GrantFiled: May 8, 1984Date of Patent: August 5, 1986Assignee: Otsuka Kagaku Kabushiki KaishaInventors: Shigeru Torii, Hideo Tanaka, Junzo Nogami, Michio Sasaoka, Norio Saito, Takashi Shiroi
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Patent number: 4475992Abstract: Cyclohexadiene derivatives represented by the formula (I) ##STR1## (wherein --X-- represents ##STR2## --Y-- represents ##STR3## and R.sup.1 and R.sup.2 represent a lower alkyl group) and a process for preparing the same.Type: GrantFiled: June 3, 1983Date of Patent: October 9, 1984Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Mitsuo Akada, Tsunehiko Masatomi, Yasuo Shimizu, Shigeru Torii, Hideo Tanaka
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Patent number: 4429164Abstract: Cyclohexadiene derivatives represented by the formula (I) ##STR1## (wherein --X-- represents ##STR2## --Y-- represents ##STR3## and R.sup.1 and R.sup.2 represent a lower alkyl group) and a process for preparing the same.Type: GrantFiled: June 22, 1982Date of Patent: January 31, 1984Assignee: Otsuka Kagaku Yakuhin Kabushini KaishaInventors: Shigeru Torii, Hideo Tanaka, Mitsuo Akada, Tsunehiko Masatomi, Yasuo Shimizu
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Patent number: 4339607Abstract: Anisaldehyde is prepared by performing at least once the steps of (a) electrolyzing cerium (III) nitrate or ammonium cerium (III) nitrate to obtain water containing cerium (IV) nitrate or ammonium cerium (IV) nitrate and/or a solution of lower alcohol containing the cerium (IV) salt, and (b) oxidizing p-methyl anisole to anisaldehyde with the cerium (IV) salt-containing solution of lower alcohol with or without the water contained therein, or with the cerium (IV) salt-containing water having a lower alcohol admixed therewith.Type: GrantFiled: July 21, 1980Date of Patent: July 13, 1982Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Shigeru Torii, Shoji Nakane, Toshifumi Shirakawa, Mitsuo Akada