Abstract: The present inventors have found that HMGB1 fragment peptides having a particular amino acid sequence exhibit the effects of improvement of cardiac function, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of dilated cardiomyopathy, that the particular HMGB1 fragment peptides also exhibit the effects of improvement of cardiac function, inhibition of cardiomegaly, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of ischemic cardiomyopathy caused by old myocardial infarction, and that the particular HMGB1 fragment peptides exhibit the effects of inhibition of cardiomyocyte hypertrophy and inhibition of myocardial fibrosis in an animal model of hypertensive cardiomyopathy.

Abstract: A method for manufacturing a three-dimensional shaped object includes a first step of specifying a gap portion sandwiched between a first partial path and a second partial path to which a shaping material is discharged from a discharge unit after the first partial path, based on first data including path data representing a path in which the discharge unit moves while discharging the shaping material by a plurality of partial paths, and including discharge control data including at least one of discharge amount information representing a discharge amount of the shaping material in each partial path and movement speed information representing a movement speed of the discharge unit in each partial path, and a second step of, when the gap portion is specified, generating second data from the first data by changing the discharge control data corresponding to the first partial path such that a width of the shaping material deposited on the stage in the first partial path increases.

Abstract: A control device communicating with a plurality of three-dimensional shaping devices is provided. The control device includes a display control unit configured to display, on a display unit, time information indicating a time, operation information including information indicating a shaping time of a model in each of the three-dimensional shaping devices, and remaining amount information indicating a remaining amount of a material used in the three-dimensional shaping device selected from the plurality of three-dimensional shaping devices. The display control unit displays the operation information corresponding to the time information, and the display control unit displays the time information in a specified scale or a specified time zone.

Abstract: A three-dimensional shaping apparatus includes a plasticizing section that includes a drive motor, a heater, and a screw rotated by the drive motor and that plasticizes a material to form a shaping material, an ejection section that ejects the shaping material toward a stage, a moving mechanism section that changes a relative position of the ejection section to the stage, a prediction section that predicts a residual service life of the heater from an observation result of a state observation section that observes a state of the heater, and a control unit that controls the plasticizing section and the moving mechanism section to shape a three-dimensional shaped article.

Abstract: To provide a method for manufacturing a three-dimensional shaped object in which a three-dimensional shaped object is manufactured by discharging a shaping material from a discharge unit. The method for manufacturing a three-dimensional shaped object includes: (A) a step of generating first shaping data including information on a first discharge path for forming an outer shell shape of the three-dimensional shaped object, and information for specifying a line width of the first discharge path; (B) a step of generating second shaping data including information on a second discharge path for filling an infill area that is an inner side portion of the outer shell shape, and information for specifying a line width of the second discharge path; and (C) a step of shaping the three-dimensional shaped object according to the first shaping data and the second shaping data.

Abstract: Provided is a method for manufacturing a three-dimensional shaped object. The method for manufacturing the three-dimensional shaped object includes: a first step of receiving designation of a shaping mode of the three-dimensional shaped object; a second step of shaping, based on shaping data for shaping the three-dimensional shaped object, the three-dimensional shaped object by discharging a shaping material from a nozzle; and a third step of controlling cleaning of the nozzle in accordance with the shaping mode received in the first step.

Abstract: There is provided a three-dimensional shaping device that shapes a three-dimensional shaped object by laminating a layer. The three-dimensional shaping device includes: an ejection unit configured to eject a shaping material toward a table; a measurement unit configured to measure the shaping material at a measurement position separated from an ejection position of the ejection unit by a predetermined distance; a position changing unit configured to relatively move the ejection position and the measurement position with respect to the table; and a control unit. A movement range in which the measurement position is moved is wider than a shaping region where the shaping material is deposited on the table.

Abstract: An information processing device includes a data processing unit that specifies a void region of a three-dimensional shaped object based on shaping data for shaping the three-dimensional shaped object, the shaping data including path information indicating a movement path of a discharge unit that moves while discharging a shaping material and discharge amount information indicating a discharge amount of the shaping material in the movement path; and a display control unit that display, on a display unit, at least a part of first shape data indicating a shape of the three-dimensional shaped object generated based on the shaping data, in which the display control unit performs, on the display unit, a display that can specify the void region in at least a part of the first shape data.

Abstract: A three-dimensional shaping apparatus includes a plasticizing section that includes a drive motor, a heater, and a screw rotated by the drive motor and that plasticizes a material to form a shaping material, a moving mechanism section that changes a relative position of an ejection section that ejects the shaping material toward a stage to the stage, a state observation section that observes a state of the drive motor or the heater, a prediction section that predicts a service life arrival time of the drive motor or the heater from an observation result of the state observation section, a notification section, and a control unit that controls the plasticizing section and the moving mechanism section to shape a three-dimensional shaped article based on shaping data.

Abstract: A three-dimensional shaped article manufacturing method includes: a first shaping step of forming a first layer in contact with a stage provided with a recess portion by moving a discharge unit while discharging a first shaping material; and a second shaping step of stacking a second layer on the first layer by moving the discharge unit while discharging a second shaping material from the discharge unit toward the first layer, in which the first shaping step includes acquiring first data including a first route; acquiring stage data indicating a position of the recess portion; a first data changing step of generating first changed data based on the first data such that an overlap degree between the first changed route and the recess portion is larger than an overlap degree between the first route and the recess portion, and forming the first layer according to the first changed data.

Abstract: A method for manufacturing a three-dimensional shaped object includes a first step of specifying a gap portion sandwiched between a first partial path and a second partial path to which a shaping material is discharged from a discharge unit after the first partial path, based on first data including path data representing a path in which the discharge unit moves while discharging the shaping material by a plurality of partial paths, and including discharge control data including at least one of discharge amount information representing a discharge amount of the shaping material in each partial path and movement speed information representing a movement speed of the discharge unit in each partial path, and a second step of, when the gap portion is specified, generating second data from the first data by changing the discharge control data corresponding to the first partial path such that a width of the shaping material deposited on the stage in the first partial path increases.

Abstract: There is provided a three-dimensional shaping device that shapes a three-dimensional shaped object by laminating a layer. The three-dimensional shaping device includes: an ejection unit configured to eject a shaping material toward a table; a measurement unit configured to measure the shaping material at a measurement position separated from an ejection position of the ejection unit by a predetermined distance; a position changing unit configured to relatively move the ejection position and the measurement position with respect to the table; and a control unit. A movement range in which the measurement position is moved is wider than a shaping region where the shaping material is deposited on the table.

Abstract: A three-dimensional shaping apparatus includes a plasticizing section that includes a drive motor, a heater, and a screw rotated by the drive motor and that plasticizes a material to form a shaping material, an ejection section that ejects the shaping material toward a stage, a moving mechanism section that changes a relative position of the ejection section to the stage, a prediction section that predicts a residual service life of the heater from an observation result of a state observation section that observes a state of the heater, and a control unit that controls the plasticizing section and the moving mechanism section to shape a three-dimensional shaped article.

Abstract: A three-dimensional shaping apparatus includes a plasticizing section that includes a drive motor, a heater, and a screw rotated by the drive motor and that plasticizes a material to form a shaping material, a moving mechanism section that changes a relative position of an ejection section that ejects the shaping material toward a stage to the stage, a state observation section that observes a state of the drive motor or the heater, a prediction section that predicts a service life arrival time of the drive motor or the heater from an observation result of the state observation section, a notification section, and a control unit that controls the plasticizing section and the moving mechanism section to shape a three-dimensional shaped article based on shaping data.

Abstract: A three-dimensional shaping apparatus includes a table at which a stacked body is shaped, a nozzle that ejects a shaping material, a sensor including at least one of a first sensor that detects a temperature of the shaping material ejected from the nozzle and a second sensor that detects an ejection state of the shaping material ejected from the nozzle, and a control unit that executes a feedback process for controlling drive of the three-dimensional shaping apparatus based on a detection result of the sensor, wherein the control unit executes the feedback process under first control when a first portion of the stacked body is shaped, executes the feedback process under second control when a second portion that is different from the first portion of the stacked body is shaped, and makes an execution frequency of the feedback process different between the first control and the second control.

Abstract: A three-dimensional shaped article manufacturing method includes: a first shaping step of forming a first layer in contact with a stage provided with a recess portion by moving a discharge unit while discharging a first shaping material toward the stage; and a second shaping step of stacking a second layer on the first layer by moving the discharge unit while discharging a second shaping material from the discharge unit toward the first layer, in which the first shaping step includes acquiring first data including a first route that is a route on which the discharge unit moves while discharging the first shaping material; acquiring stage data indicating a position of the recess portion; a first data changing step of generating, based on the first data and the stage data, first changed data including a first changed route obtained by changing the first route, that is, generating the first changed data based on the first data such that an overlap degree between the first changed route and the recess portion is

Abstract: To provide a method for manufacturing a three-dimensional shaped object in which a three-dimensional shaped object is manufactured by discharging a shaping material from a discharge unit. The method for manufacturing a three-dimensional shaped object includes: (A) a step of generating first shaping data including information on a first discharge path for forming an outer shell shape of the three-dimensional shaped object, and information for specifying a line width of the first discharge path; (B) a step of generating second shaping data including information on a second discharge path for filling an infill area that is an inner side portion of the outer shell shape, and information for specifying a line width of the second discharge path; and (C) a step of shaping the three-dimensional shaped object according to the first shaping data and the second shaping data.

Abstract: An image forming apparatus comprises: a piezoelectric sensor that produces an variable output signal depending on the amount of infrared energy; a human body detecting device having a lens that forms a detecting area serving for detecting if the person enters; a peak detector that detects a peak of an output signal produced when the person enters the detecting area; an offset voltage judgment portion that judges if the output signal falls to the offset voltage after the peak; a moving direction judgment portion that judges the direction in which the person moves in the detecting area; and a mode controller that switches the power supply mode to a first mode if the power supply mode is found to be a second mode requiring less power than the first mode while the moving direction judgment portion judges that the person moves toward the image forming apparatus.

Abstract: An accelerator pedal apparatus includes an accelerator pedal, a hysteresis generating mechanism which generates hysteresis on pedaling force, a reaction force adding mechanism which adds reaction force to push back the accelerator pedal toward a rest position, and controller which performs drive control of the reaction force adding mechanism, while the controller performs drive control of the reaction force adding mechanism so that reaction force is added during returning as well as during depressing of the accelerator pedal under predetermined conditions as the reaction force being larger than pedaling force difference between pedaling force at the depression side and pedaling force at the return side of the pedaling force hysteresis to obtain an appropriate accelerator feeling and to quickly perform danger avoidance or danger notification.