Patents by Inventor Shigeto Uchiyama
Shigeto Uchiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230270142Abstract: An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc. The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.Type: ApplicationFiled: September 29, 2022Publication date: August 31, 2023Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hiroyuki KIMURA, Takeshi YAMAUCHI, Tomomi UENO, Toshimi SUZUKI, Kentaro TADANO, Ikutaro SATO, Shigeto UCHIYAMA, Masahiro OONO, Masatoshi MIZUNO
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Publication number: 20190038684Abstract: An equol-producing lactic acid bacteria-containing composition comprises, as an essential component thereof, a lactic acid bacterial strain belonging to the genus Lactococcus having an ability to utilize at least one daidzein compound selected from the group consisting of daidzein glycosides, daidzein, and dihydrodaidzein to produce equol. Such a composition is effective for the prevention and alleviation of malaise inclusive of climacteric disturbance in middle-aged and elderly women for which no effective prophylactic method or alleviating means has heretofore been available.Type: ApplicationFiled: October 12, 2018Publication date: February 7, 2019Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Shigeto UCHIYAMA, Tomomi UENO, Toshimi SUZUKI
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Patent number: 10098915Abstract: An equol-producing lactic acid bacteria-containing composition comprises, as an essential component thereof, a lactic acid bacterial strain belonging to the genus Lactococcus having an ability to utilize at least one daidzein compound selected from the group consisting of daidzein glycosides, daidzein, and dihydrodaidzein to produce equol. Such a composition is effective for the prevention and alleviation of malaise inclusive of climacteric disturbance in middle-aged and elderly women for which no effective prophylactic method or alleviating means has heretofore been available.Type: GrantFiled: September 24, 2013Date of Patent: October 16, 2018Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Shigeto Uchiyama, Tomomi Ueno, Toshimi Suzuki
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Publication number: 20180235260Abstract: An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc. The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.Type: ApplicationFiled: April 18, 2018Publication date: August 23, 2018Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hiroyuki KIMURA, Takeshi YAMAUCHI, Tomomi UENO, Toshimi SUZUKI, Kentaro TADANO, Ikutaro SATO, Shigeto UCHIYAMA, Masahiro OONO, Masatoshi MIZUNO
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Patent number: 9951360Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.Type: GrantFiled: June 30, 2015Date of Patent: April 24, 2018Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yoshikazu Isono, Hisako Mori, Tomomi Ueno, Rieko Endo, Megumi Kumemura, Yasuhiro Abiru, Shigeto Uchiyama
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Patent number: 9386786Abstract: An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc. The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.Type: GrantFiled: July 16, 2012Date of Patent: July 12, 2016Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hiroyuki Kimura, Takeshi Yamauchi, Tomomi Ueno, Toshimi Suzuki, Kentaro Tadano, Ikutaro Sato, Shigeto Uchiyama, Masahiro Oono, Masatoshi Mizuno
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Publication number: 20150299748Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.Type: ApplicationFiled: June 30, 2015Publication date: October 22, 2015Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yoshikazu ISONO, Hisako MORI, Tomomi UENO, Rieko ENDO, Megumi KUMEMURA, Yasuhiro ABIRU, Shigeto UCHIYAMA
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Patent number: 9101159Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.Type: GrantFiled: September 18, 2009Date of Patent: August 11, 2015Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Yoshikazu Isono, Hisako Mori, Tomomi Ueno, Rieko Endo, Megumi Kumemura, Yasuhiro Abiru, Shigeto Uchiyama
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Patent number: 8765445Abstract: The present invention provides an equol-producing lactic acid bacteria-containing composition comprising, as an essential component thereof, a lactic acid bacterial strain belonging to the genus Lactococcus having an ability to utilize at least one daidzein compound selected from the group consisting of daidzein glycosides, daidzein, and dihydrodaidzein to produce equol. Such a composition is effective for the prevention and alleviation of malaise inclusive of climacteric disturbance in middle-aged and elderly women for which no effective prophylactic method or alleviating means has heretofore been available.Type: GrantFiled: June 29, 2004Date of Patent: July 1, 2014Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Shigeto Uchiyama, Tomomi Ueno, Toshimi Suzuki
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Publication number: 20140050703Abstract: An equol-producing lactic acid bacteria-containing composition comprises, as an essential component thereof, a lactic acid bacterial strain belonging to the genus Lactococcus having an ability to utilize at least one daidzein compound selected from the group consisting of daidzein glycosides, daidzein, and dihydrodaidzein to produce equol. Such a composition is effective for the prevention and alleviation of malaise inclusive of climacteric disturbance in middle-aged and elderly women for which no effective prophylactic method or alleviating means has heretofore been available.Type: ApplicationFiled: September 24, 2013Publication date: February 20, 2014Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Shigeto UCHIYAMA, Tomomi UENO, Toshimi SUZUKI
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Publication number: 20120277303Abstract: An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc. The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.Type: ApplicationFiled: July 16, 2012Publication date: November 1, 2012Applicant: OTSUKA PHARMACEUTICAL CO., LTDInventors: Hiroyuki KIMURA, Takeshi YAMAUCHI, Tomomi UENO, Toshimi SUZUKI, Kentaro TADANO, Ikutaro SATO, Shigeto UCHIYAMA, Masahiro OONO, Masatoshi MIZUNO
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Publication number: 20120277302Abstract: An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc. The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.Type: ApplicationFiled: July 16, 2012Publication date: November 1, 2012Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Hiroyuki Kimura, Takeshi Yamauchi, Tomomi Ueno, Toshimi Suzuki, Kentaro Tadano, Ikutaro Sato, Shigeto Uchiyama, Masahiro Oono, Masatoshi Mizuno
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Publication number: 20110189134Abstract: An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.Type: ApplicationFiled: September 18, 2009Publication date: August 4, 2011Applicants: OTSUKA PHARMACEUTICAL CO., LTD., OTSUKA FOODS CO., LTD.Inventors: Yoshikazu Isono, Hisako Mori, Tomomi Ueno, Rieko Endo, Megumi Kumemura, Yasuhiro Abiru, Shigeto Uchiyama
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Patent number: 7939060Abstract: This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly women for which no effective means of prevention or alleviation has heretofore been available.Type: GrantFiled: January 9, 2008Date of Patent: May 10, 2011Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Shigeto Uchiyama, Tomomi Ueno, Megumi Kumemura, Kiyoko Imaizumi, Kyosuke Masaki, Seiichi Shimizu
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Publication number: 20090311353Abstract: An object of the invention is to provide an equol-containing fermented soybean hypocotyl material that is useful for foods, pharmaceutical preparations, cosmetic products, etc. The equol-containing fermented soybean hypocotyl material of the invention is obtained by fermenting soybean hypocotyls using at least one microorganism having an equol-producing ability by utilizing at least one daidzein compound selected from the group consisting of diadzein glycosides, daidzein, and dihydrodaidzein.Type: ApplicationFiled: December 5, 2006Publication date: December 17, 2009Applicant: OTSUKA PHARMACEUTICAL CO., LTDInventors: Hiroyuki Kimura, Takeshi Yamauchi, Tomomi Ueno, Toshimi Suzuki, Kentaro Tadano, Ikutaro Sato, Shigeto Uchiyama, Masahiro Oono, Masatoshi Mizuno
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Publication number: 20080131412Abstract: This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly women for which no effective means of prevention or alleviation has heretofore been available.Type: ApplicationFiled: January 9, 2008Publication date: June 5, 2008Inventors: Shigeto Uchiyama, Tomomi Ueno, Megumi Kumemura, Kiyoko Imaizumi, Kyosuke Masaki, Seiichi Shimizu
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Patent number: 7345089Abstract: This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly women for which no effective means of prevention or alleviation has heretofore been available.Type: GrantFiled: January 8, 2004Date of Patent: March 18, 2008Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Shigeto Uchiyama, Tomomi Ueno, Megumi Kumemura, Kiyoko Imaizumi, Kyosuke Masaki, Seiichi Shimizu
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Publication number: 20060148045Abstract: The present invention provides an equol-producing lactic acid bacteria-containing composition comprising, as an essential component thereof, a lactic acid bacterial strain belonging to the genus Lactococcus having an ability to utilize at least one daidzein compound selected from the group consisting of daidzein glycosides, daidzein, and dihydrodaidzein to produce equol. Such a composition is effective for the prevention and alleviation of malaise inclusive of climacteric disturbance in middle-aged and elderly women for which no effective prophylactic method or alleviating means has heretofore been available.Type: ApplicationFiled: June 29, 2004Publication date: July 6, 2006Inventors: Shigeto Uchiyama, Tomomi Ueno, Toshimi Suzuki
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Patent number: 6884415Abstract: The antioxidation food product of the present invention is produced by fermenting a food product containing bacteria having catalase activity, such as Lactobacillus plantarum, in the presence of a manganese-containing natural material. The antioxidation food product has antioxidation activity in viva, including the digestive tract, by simultaneously expressing a superoxide dismutase-like activity and a catalase activity, and is effective for preventing disease caused by active oxygen.Type: GrantFiled: December 21, 2001Date of Patent: April 26, 2005Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Masamichi Toba, Shigeto Uchiyama, Reiko Ohta, Seiichi Shimizu, Shuichi Sakamoto
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Publication number: 20040141954Abstract: This invention provides a composition comprising a daidzein-containing substrate and a strain of micro-organism capable of metabolizing daidzein to equol as essential ingredients. This composition is effective in the prevention and alleviation of unidentified clinical syndrome inclusive of menopausal syndrome in middle-aged to elderly women for which no effective means of prevention or alleviation has heretofore been avai lable.Type: ApplicationFiled: January 8, 2004Publication date: July 22, 2004Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Shigeto Uchiyama, Tomomi Ueno, Megumi Kumemura, Kiyoko Imaizumi, Kyosuke Masaki, Seiichi Shimizu