Abstract: An optical lens includes an optical zone, and the optical zone includes a relax zone, a distance zone, and a defocus zone. The distance zone surrounds the relax zone. The defocus zone surrounds the distance zone and the relax zone. The diopter of the relax zone reduces along a direction from a center of the optical zone to an edge of the optical zone.

Abstract: A combinable nucleic acid pre-processing apparatus includes a sample transfer chamber transferring a sample from a sampling tube to a nucleic acid extraction kit, a nucleic acid extraction chamber performing a nucleic acid extraction of the sample in the nucleic acid extraction kit for obtaining a nucleic acid extract, an assay setup chamber preparing reagents and transferring reagents and the nucleic acid extract to an assay plate, and at least two bridging modules respectively disposed between the sample transfer chamber and the nucleic acid extraction chamber and between the nucleic acid extraction chamber and the assay setup chamber. The sample transfer chamber, the nucleic acid extraction chamber and the assay setup chamber are separated and operated independently. Three chambers are connected through the bridging modules, so the nucleic acid extraction kit can be sequentially moved in the sample transfer chamber, the nucleic acid extraction chamber and the assay setup chamber.

Abstract: An integrated circuit includes a gate structure over a substrate. The integrated circuit includes a first silicon-containing material structure in a recess. The first silicon-containing material structure includes a first layer below a top surface of the substrate and in direct contact with the substrate. The first silicon-containing material structure includes a second layer over the first layer, wherein an entirety of the second layer is above the top surface of the substrate, a first region of the second layer closer to the gate structure is thinner than a second region of the second layer farther from the gate structure. The first silicon-containing material structure includes a third layer between the first layer and the second layer, wherein at least a portion of the third layer is below the top surface of the substrate.

Abstract: Provided is an expression vector including a nucleotide sequence for encoding lysine decarboxylase CadA, and a sequence of a constitutive promoter for regulating the expression of the nucleotide sequence. Also provided is a recombinant microorganism including the expression vector and a method of producing 1,5-diaminopentane by using the recombinant microorganism.

Abstract: Provided is an expression vector including a nucleotide sequence for encoding lysine decarboxylase CadA, and a sequence of a constitutive promoter for regulating the expression of the nucleotide sequence. Also provided is a recombinant microorganism including the expression vector and a method of producing 1,5-diaminopentane by using the recombinant microorganism.

Abstract: An embeddable micro-needle patch for transdermal drug delivery and method of manufacturing the same are disclosed. The embeddable micro-needle patch for transdermal drug delivery comprises a supporting substrate, on which the surface includes a plurality of extruded supporting shafts; a biodegradable carrier, which is formed of biodegradable polymer material and disposed on the supporting shaft; and drugs, which are encapsulated in the biodegradable carrier. When the embeddable micro-needle patch for transdermal drug delivery is attached to the skin for a predetermined time, the biodegradable carrier is separated from the supporting shafts and embedded into the skin, and the biodegradable carrier may swell and then degrade, so as to release the drugs, which are encapsulated in the biodegradable carrier, at a rate of 1%-99% loaded drug per day into the skin. Accordingly, velocity of releasing the drugs may be regulated, so as to sustain the drug efficacy.

Abstract: An embeddable micro-needle patch for transdermal drug delivery and method of manufacturing the same are disclosed. The embeddable micro-needle patch for transdermal drug delivery comprises a supporting substrate, on which the surface includes a plurality of extruded supporting shafts; a biodegradable carrier, which is formed of biodegradable polymer material and disposed on the supporting shaft; and drugs, which are encapsulated in the biodegradable carrier. When the embeddable micro-needle patch for transdermal drug delivery is attached to the skin for a predetermined time, the biodegradable carrier is separated from the supporting shafts and embedded into the skin, and the biodegradable carrier may swell and then degrade, so as to release the drugs, which are encapsulated in the biodegradable carrier, at a rate of 1%˜99% loaded drug per day into the skin. Accordingly, velocity of releasing the drugs may be regulated, so as to sustain the drug efficacy.

Abstract: This is one analysis method about probing into relationship of beating signal and heart function. It is used to deal with one beating signal, which is measured from one subject under any activity condition in a period of time with an electric manometer. And this analysis could be the reference target of the heart function of the subject. This method includes: (1) to transform the beating signal into the power spectrum, (2) to normalize the outcome of the power spectrum transformation, and (3) to compute an advance defining heart index from the normalized power spectrum diagram, and supply the reference target of the heart function from the subject with the heart index.

Abstract: This is one analysis method about probing into relationship of beating signal and heart function. It is used to deal with one beating signal, which is measured from one subject under any activity condition in a period of time with an electric manometer. And this analysis could be the reference target of the heart function of the subject. This method includes: (1) to transform the beating signal into the power spectrum, (2) to normalize the outcome of the power spectrum transformation, and (3) to compute an advance defining heart index from the normalized power spectrum diagram, and supply the reference target of the heart function from the subject with the heart index.