Abstract: Provided herein are methods for treating a subject suffering from a cutaneous neutrophilic inflammatory disease comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein each variable position is as defined herein. In some embodiments, the cutaneous neutrophilic inflammatory disease is Hidradenitis suppurativa (HS).

Abstract: Provided are a wavelength conversion apparatus, a light source system including the same, and a display device including the light source system. The wavelength conversion apparatus includes an angle deflection region and a wavelength conversion region for converting incident second light into excited light and then emitting same. The angle deflection region includes deflection units, each of which includes a light emergent face for emitting first light. A first included angle is formed between the light emergent face and a reference plane. First included angles between light emergent faces of at least two deflection units and the reference plane are not equal. The deflection units are located on a light path of the first light in a time sequence, so as to change an emergent angle of the first light in the time sequence, such that the first light is successively scanned at a preset position to form virtual pixels.

Abstract: The present disclosure is drawn to the combination therapy of a Chemokine Receptor 2 (CCR2) antagonist and a PD-1 and/or PD-L1 inhibitor in the treatment of cancer.

Abstract: An LED display screen, comprising: an LED array, consisting of multiple LED light-emitting units and used for emitting a light; an optical diffusion film, provided at a light exit side of the LED array; a matrix shading frame, comprising multiple hollow shading gratings, the hollow shading gratings corresponding one-to-one to the LED light-emitting units; and a substrate, used for supporting the LED array and the matrix shading frame, where the light emitted by the LED light-emitting units, after running through the hollow shading gratings, is diffused to a viewer side via the optical diffusion film, and the LED light-emitting units emit the light towards the hollow shading gratings. The LED display screen prevents external ambient lights from being shone to optical surfaces of the LED light-emitting units and being reflected thereby, thus increasing the contrast of the LED display screen.

Abstract: Provided herein are methods of treating certain cancers comprising administering to the subject in need there of an effective amount of a compound of Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Ra, and Rb are as defined herein.

Abstract: Disclosed is an LED display screen, including an LED array including LED light emitting units and arranged on a substrate, a diffusion film arranged at a light-exiting side of the LED array, and a matrix light-shielding frame arranged between the LED array and the diffusion film. A hollow grid array including hollow grids is included. The hollow grids correspond one-to-one to the LED light emitting units and a projection of each hollow grid on the substrate surrounds a corresponding one of the plurality of LED light emitting units. Light emitted from the LED array can pass through a projection region of the matrix light-shielding frame on the diffusion film and exiting therefrom.

Abstract: The present disclosure provides, inter alia, methods of treating cancer by administering an effective amount of a com-pound of Formula (I). In some embodiments, the cancer is a solid cancer. In some embodiments, the cancer is melanoma. In some aspects, the present disclosure provides methods of increasing the CD8+ T cell/CD4+ T cell ratio in a solid tumor microenvironment by administering an effective amount of a compound of Formula (I).

Abstract: A plasmonic sensor with gradient nanostructures and a method of use thereof is provided. The gradient of shapes will induce different spectral responses at different region of the sensor and show different colors. When there is a change in the environment properties of a substance, such as refractive index, gas concentration or ion density changes, the sensor displays different images, e.g., redial intensity displays and radial color displays. An image recognition based method can be used to extract the environment property with high accuracy according to the sensor image.

Abstract: A plasmonic sensor with gradient nanostructures and a method of use thereof is provided. The gradient of shapes will induce different spectral responses at different region of the sensor and show different colors. When there is a change in the environment properties of a substance, such as refractive index, gas concentration or ion density changes, the sensor displays different images, e.g., redial intensity displays and radial color displays. An image recognition based method can be used to extract the environment property with high accuracy according to the sensor image.

Abstract: The present disclosure is drawn to the combination therapy of a C—C Chemokine Receptor 4 (CCR4) antagonist and one or more immune checkpoint inhibitors in the treatment of cancer.

Abstract: An apparatus for processing spread spectrum signals is disclosed. The apparatus includes an intermediate frequency (IF) signal preprocessing unit, which includes a first set of multiply-accumulator (MAC) units and a second set of MAC units. The IF signal preprocessing unit generates a first and a second set of data streams using a digitized signal and a first and second local reference signals respectively. Each data stream is generated every predetermined time period, and each data stream includes pre-integration results generated at a predetermined rate.

Abstract: The present invention is a method for GPS positioning in a weak signal environment. The method includes obtaining assistance data for a GPS signal from a satellite at a predetermined time, wherein the assistance data including predicted navigation data, Doppler shift and Doppler shift rate and the GPS signal being modulated by a carrier signal, a pseudorandom code and navigation data, estimating a predicted receiving time for the GPS signal reaching the GPS receiver, capturing the GPS signal, converting the GPS signal to an intermediate frequency signal, acquiring a code phase of the pseudorandom code from the intermediate frequency signal by using the assistance data and the predicted receiving time, and obtaining a position for the GPS receiver based on the predicted navigation data and the code phase of the pseudorandom code.

Abstract: A method for estimating signal quality of a spread spectrum signal is provided. The method includes squaring a plurality of in-phase correlation results and a plurality of quadrature correlation results, summing each squared in-phase correlation result and the corresponding correlation result to obtain a plurality of sum-of-square values, detecting a peak value among the plurality of sum-of-square results, calculating an average of non-peak values among the plurality of sum-of-square results. The peak value is regarded as a signal power value, while the averaged non-peak values are regarded as an average noise power value. A signal-to-noise ratio is then calculated based on the signal power value and the average noise power value. A method for determining the parameters for the tracking loop is also provided. The method includes estimating the signal-to-noise ratio of the spread spectrum signal, and determining the tracking loop parameters based on the signal-to-noise ratio.

Abstract: An apparatus for processing spread spectrum signals is disclosed. The apparatus includes an intermediate frequency (IF) signal preprocessing unit, which includes a first set of multiply-accumulator (MAC) units and a second set of MAC units. The IF signal preprocessing unit generates a first and a second set of data streams using a digitized signal and a first and second local reference signals respectively. Each data stream is generated every predetermined time period, and each data stream includes pre-integration results generated at a predetermined rate.

Abstract: An apparatus for processing spread spectrum signals digitized at a predetermined sampling frequency. The apparatus includes an intermediate frequency signal preprocessing unit, a plurality of parallel block integrators. The intermediate frequency signal preprocessing unit is capable of generating pre-integration results based on an input signal and local reference signals at a predetermined rate. The pre-integration results produced by the intermediate frequency signal preprocessing unit are grouped into sets of pre-integration results. Each set of the pre-integration results contains a predetermined number of pre-integration results. The plurality of parallel block integrators is in communication with the intermediate frequency signal preprocessing unit.

Abstract: A method for processing spread spectrum signals through a two step integration process in a circuit having an intermediate frequency signal preprocessing unit and a plurality of block integrators, wherein the circuit receiving a digitized signal, a local reference signal, and a pseudorandom noise code. The method includes generating a plurality of data streams by the intermediate frequency signal preprocessing unit using the digitized signal and the reference signal, receiving at each block integrator a data stream from the plurality of data streams and the pseudorandom noise code, performing a predetermined number of partial correlations at each block integrator using hybrid correlation technique based on the data stream and the pseudorandom noise code to obtain a predetermined number of partial correlation results, and computing a predetermined number of complete correlation results based on the predetermined number of partial correlation results.

Abstract: A method for estimating signal quality of a spread spectrum signal is provided. The method includes squaring a plurality of in-phase correlation results and a plurality of quadrature correlation results, summing each squared in-phase correlation result and the corresponding correlation result to obtain a plurality of sum-of-square values, detecting a peak value among the plurality of sum-of-square results, calculating an average of non-peak values among the plurality of sum-of-square results. The peak value is regarded as a signal power value, while the averaged non-peak values are regarded as an average noise power value. A signal-to-noise ratio is then calculated based on the signal power value and the average noise power value. A method for determining the parameters for the tracking loop is also provided. The method includes estimating the signal-to-noise ratio of the spread spectrum signal, and determining the tracking loop parameters based on the signal-to-noise ratio.

Abstract: The present invention is a method for GPS positioning in a weak signal environment. The method includes obtaining assistance data for a GPS signal from a satellite at a predetermined time, wherein the assistance data including predicted navigation data, Doppler shift and Doppler shift rate and the GPS signal being modulated by a carrier signal, a pseudorandom code and navigation data, estimating a predicted receiving time for the GPS signal reaching the GPS receiver, capturing the GPS signal, converting the GPS signal to an intermediate frequency signal, acquiring a code phase of the pseudorandom code from the intermediate frequency signal by using the assistance data and the predicted receiving time, and obtaining a position for the GPS receiver based on the predicted navigation data and the code phase of the pseudorandom code.

Abstract: A method for processing spread spectrum signals through a two step integration process in a circuit having an intermediate frequency signal preprocessing unit and a plurality of block integrators, wherein the circuit receiving a digitized signal, a local reference signal, and a pseudorandom noise code. The method includes generating a plurality of data streams by the intermediate frequency signal preprocessing unit using the digitized signal and the reference signal, receiving at each block integrator a data stream from the plurality of data streams and the pseudorandom noise code, performing a predetermined number of partial correlations at each block integrator using hybrid correlation technique based on the data stream and the pseudorandom noise code to obtain a predetermined number of partial correlation results, and computing a predetermined number of complete correlation results based on the predetermined number of partial correlation results.

Abstract: An apparatus for processing spread spectrum signals digitized at a predetermined sampling frequency. The apparatus includes an intermediate frequency signal preprocessing unit, a plurality of parallel block integrators. The intermediate frequency signal preprocessing unit is capable of generating pre-integration results based on an input signal and local reference signals at a predetermined rate. The pre-integration results Produced by the intermediate frequency signal preprocessing unit are grouped into sets of pre-integration results. Each set of the pre-integration results contains a predetermined number of pre-integration results. The plurality of parallel block integrators is in communication with the intermediate frequency signal preprocessing unit.