Patents by Inventor Shimon Reif

Shimon Reif has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220202866
    Abstract: The present invention is directed to compositions containing exosomes isolated from milk and methods and uses thereof for treating inflammatory bowel disease (IBD) and conditions related thereto. In particular, disclosed are exosomes derived from milk and enteral formulations supplemented therewith for use in treating IBD. The compositions are preferably formulated for rectal administration and the exosomes comprise one or more miRNA molecules and TGF-?.
    Type: Application
    Filed: May 13, 2020
    Publication date: June 30, 2022
    Inventors: Shimon REIF, Regina GOLAN-GERSTL
  • Patent number: 10874114
    Abstract: Provided are microvesicles isolated from milk, compositions thereof and uses for the preparation of milk formulas. Further provided are microvesicles, including exosomes and/or fat globules which encapsulate various miRNA molecules and uses thereof, as exemplified by supplementing milk formulas.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: December 29, 2020
    Assignee: Hadasit Medical Research Services and Development Ltd.
    Inventors: Shimon Reif, Regina Golan
  • Publication number: 20180343882
    Abstract: Provided are microvesicles isolated from milk, compositions thereof and uses for the preparation of milk formulas. Further provided are microvesicles, including exosomes and/or fat globules which encapsulate various miRNA molecules and uses thereof, as exemplified by supplementing milk formulas.
    Type: Application
    Filed: November 29, 2016
    Publication date: December 6, 2018
    Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventors: Shimon REIF, Regina GOLAN
  • Publication number: 20050119237
    Abstract: Disclosed is a method for inhibiting Ras-induced or mediated proliferation of cells associated with a non-malignant disease, disorder or pathological condition. The method entails administering to a patient a Ras antagonist in an amount effective to inhibit the proliferation. The invention is particularly applicable to diseases characterized by a proliferation of T-cells such as autoimmune disease, e.g., type 1 diabetes, lupus and multiple sclerosis, and pathological states such as graft rejection induced by the presentation of a foreign antigen such as a graft in response to a disease condition (e.g., kidney failure). Other non-malignant diseases characterized by proliferations of cells include cirrhosis of the liver and restenosis. Preferred Ras antagonists are S-trans-trans farnesylthiosalicylic acid (FTS) and structurally related compounds (or analogs) thereof.
    Type: Application
    Filed: June 14, 2004
    Publication date: June 2, 2005
    Applicant: Ramot University Authority for Applied Research & Industrial Development Ltd.
    Inventors: Yoel Kloog, Joab Chapman, Dimitrius Karussis, Rafael Bruck, Shimon Reif, Michael Brownstein
  • Patent number: 6462086
    Abstract: Disclosed is a method for inhibiting Ras-induced or mediated proliferation of cells associated with a non-malignant disease, disorder or pathological condition. The method entails administering to a patient a Ras antagonist in an amount effective to inhibit the proliferation. The invention is particularly applicable to diseases characterized by a proliferation of T-cells such as autoimmune disease, e.g., type 1 diabetes, lupus and multiple sclerosis, and pathological states such as graft rejection induced by the presentation of a foreign antigen such as a graft in response to a disease condition (e.g., kidney failure). Other non-malignant diseases characterized by proliferations of cells include cirrhosis of the liver and restenosis. Preferred Ras antagonists are S-trans-trans farnesylthiosalicylic acid (FTS) and structurally related compounds (or analogs) thereof.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: October 8, 2002
    Assignee: Ramot University Authority for Applied Research and Industrial Development Ltd.
    Inventors: Yoel Kloog, Joab Chapman, Dimitrius Karussis, Rafael Bruck, Shimon Reif, Michael Brownstein