Patents by Inventor Shimpei Aburaki
Shimpei Aburaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5837828Abstract: The present invention concerns neutral sugar derivatives of pradimicins, their use as antifungal agents, methods for their preparation, and intermediates for their synthesis.Type: GrantFiled: May 2, 1995Date of Patent: November 17, 1998Assignee: Bristol-Myers Squibb Co.Inventors: Shimpei Aburaki, Tetsuro Yamasaki, Toshikazu Oki, Seiji Iimura, Hajime Kamachi, Hideo Kamei, Takayuki Naito
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Patent number: 5696096Abstract: The present invention relates to new antifungal compounds having the formula ##STR1## wherein R.sup.1 is hydrogen, methyl, or hydroxymethyl; R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen and C.sub.1-5 alkyl; and R.sup.4 is selected from the group consisting of .beta.-L-xylosyl, .beta.-D-ribosyl, .alpha.-L-arabinosyl, .beta.-D-chinovosyl, .beta.-D-fucosyl, and .beta.-D-glucosyl; with the proviso that when R.sup.1 is methyl or hydroxymethyl, and one of R.sup.2 or R.sup.3 is methyl, R.sup.4 is not .beta.-D-glucosyl; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 28, 1990Date of Patent: December 9, 1997Assignee: Bristol-Myers Squibb CompanyInventors: Shimpei Aburaki, Haruhiro Yamashita, Takayuki Naito
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Patent number: 5410029Abstract: The present invention concerns neutral sugar derivatives of pradimicins, their use as antifungal agents, methods for their preparation, and intermediates for their synthesis.Type: GrantFiled: March 10, 1994Date of Patent: April 25, 1995Assignee: Bristol-Myers Squibb CompanyInventors: Shimpei Aburaki, Tetsuro Yamasaki, Toshikazu Oki, Seiji Iimura, Hajime Kamachi, Hideo Kamei, Takayuki Naito
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Patent number: 5227370Abstract: The present invention provides pradimicin analogs which exhibit improved water solubility relative to parent compounds. These novel agents are useful in treatment of fungal infections.Type: GrantFiled: December 3, 1991Date of Patent: July 13, 1993Assignee: Bristol-Myers Squibb CompanyInventors: Hajime Kamachi, Seiji Iimura, Satsuki Okuyama, Shimpei Aburaki, Takayuki Naito, Yasutsugu Ueda, Leonard B. Crast, Jr., Amarendra B. Mikkilineni
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Patent number: 4699979Abstract: This invention provides novel cephalosporin intermediates, 7.beta.-amino-3-[(Z)-1-propen-1-y1]-3-cephem-4-carboxylic acid and esters thereof having the general formula ##STR1## wherein the configuration of the 3-propenyl group is Z sometimes referred to as cis- and R is hydrogen or a conventional carboxy-protected group, or a physiologically hydrolyzable esterifying group, and acid addition salts thereof and the metal salts of the foregoing substance wherein R is hydrogen. These compounds are useful as intermediates for preparation of orally active cephalosporins.Type: GrantFiled: March 25, 1986Date of Patent: October 13, 1987Assignee: Bristol-Meyers CompanyInventors: Hideaki Hoshi, Jun Okumura, Takayuki Naito, Yoshio Abe, Shimpei Aburaki
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Patent number: 4661590Abstract: 3-[(Z)-1-Propen-1-yl]-7-acylamido cephalosporins in which the 7-acyl group is phenylglycyl or substituted phenylglycyl are orally active antibiotics against Gram+ and Gram- bacteria.Type: GrantFiled: July 31, 1985Date of Patent: April 28, 1987Assignee: Bristol-Myers CompanyInventors: Hideaki Hoshi, Jun Okumura, Takayuki Naito, Yoshio Abe, Shimpei Aburaki
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Patent number: 4659812Abstract: Temperature stable crystalline mono-hydrochloric and sulfuric acid addition salts of 7-amino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate substantially free of .DELTA..sup.2 isomer are intermediates for the preparation of broad spectrum 7-[.alpha.-(2-aminothiazol-4-yl)-.alpha.-(Z)-methoxyiminoacetamido]-3-[(1- methyl-1-pyrrolidinio)methyl]-3-cephem-4-carboxylates.Type: GrantFiled: August 20, 1985Date of Patent: April 21, 1987Assignee: Bristol-Myers CompanyInventors: Shimpei Aburaki, Yukio Narita, Jun Okumura, Takayuki Naito, Donald G. Walker
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Patent number: 4591641Abstract: 3-[(Z)-1-Propen-1-yl]-7-acylamido cephalosporins in which the 7-acyl group is phenylglycyl or substituted phenylglycyl are orally active antibiotics against Gram+ and Gram- bacteria.Type: GrantFiled: March 18, 1985Date of Patent: May 27, 1986Assignee: Bristol-Myers CompanyInventors: Hideaki Hoshi, Jun Okumura, Takayuki Naito, Yoshio Abe, Shimpei Aburaki
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Patent number: 4525473Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, R.sup.2 is a straight or branched chain alkyl, alkenyl or alkynyl containing from 1 to 4 carbon atoms, and ##STR2## is a quaternary ammonio group as described herein, and nontoxic pharmaceutically acceptable salts, physiologically hydrolyzable esters and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.Type: GrantFiled: March 30, 1983Date of Patent: June 25, 1985Assignee: Bristol-Myers CompanyInventors: Shimpei Aburaki, Hajime Kamachi, Yukio Narita, Jun Okumura, Takayuki Naito
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Patent number: 4520022Abstract: 3-[(Z)-1-Propen-1-yl]-7-acylamido cephalosporins in which the 7-acyl group is phenylglycyl or substituted phenylglycyl are orally active antibiotics against Gram+ and Gram- bacteria.Type: GrantFiled: December 28, 1983Date of Patent: May 28, 1985Assignee: Bristol-Myers CompanyInventors: Hideaki Hoshi, Jun Okumura, Takayuki Naito, Yoshio Abe, Shimpei Aburaki
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Patent number: 4500526Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, R.sup.2 is one of various alkyl, alkenyl, alkynyl, cycloalkyl, carboxyalkyl or carboxycycloalkyl moieties described herein, and R.sup.5 is hydrogen, amino, carboxy, formyl, carbamoyl, guanidino, amidino or one of various alkyl, alkoxy, alkylthio or substituted amino moieties described herein, and nontoxic pharmaceutically acceptable acid addition salts, physiologically hydrolyzable esters and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.Type: GrantFiled: October 13, 1983Date of Patent: February 19, 1985Assignee: Bristol-Myers CompanyInventors: Kiyoto Imae, Shimpei Aburaki, Yukio Narita, Jun Okumura, Takayuki Naito
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Patent number: 4486586Abstract: 7-{(Z)-2-(2-Aminothiazol-4-yl)-2-[(substituted)oxyimino]acetamido}-3-[3-(qu aternary ammonio)-1-propen-1-yl]-3-cephem-4-carboxylates and salts, esters and solvates thereof, having potent antibacterial activity, are provided. Processes for their preparation and intermediates in their preparation also are disclosed.Type: GrantFiled: February 10, 1983Date of Patent: December 4, 1984Assignee: Bristol-Myers CompanyInventors: Yukio Narita, Seiji Iimura, Shimpei Aburaki, Jun Okumura, Takayuki Naito
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Patent number: 4406899Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, and R.sup.2 is a straight or branched chain alkyl group containing from 1 to 4 carbon atoms, allyl, 2-butenyl or 3-butenyl, and nontoxic pharmaceutically acceptable salts and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.Type: GrantFiled: March 4, 1982Date of Patent: September 27, 1983Assignee: Bristol-Myers CompanyInventors: Shimpei Aburaki, Hajime Kamachi, Yukio Narita, Jun Okumura, Takayuki Naito