Patents by Inventor Shin-San Su
Shin-San Su has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100025873Abstract: An apparatus and method for forming nanoparticles employs an inkjet dispenser and a nanoparticle formation device. The inkjet dispenser includes at least one orifice. A liquid solution with a substance to be transformed into nanoscale is received in the inkjet dispenser, and is dispensed from the at least one orifice to generate a plurality of microdroplets. The nanoparticle formation device is disposed to receive the microdroplets dispensed by the inkjet dispenser and form the nanoparticles therein.Type: ApplicationFiled: October 29, 2008Publication date: February 4, 2010Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Po-Fu Chou, Pei Kan, Chun Jung Chen, Shih-Liang Yang, Chun Fu Leu, Shin-San Su
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Publication number: 20070059370Abstract: An apparatus and method for forming nanoparticles employs an inkjet dispenser and a nanoparticle formation device. The inkjet dispenser includes at least one orifice. A liquid solution with a substance to be transformed into nanoscale is received in the inkjet dispenser, and is dispensed from the at least one orifice to generate a plurality of microdroplets. The nanoparticle formation device is disposed to receive the microdroplets dispensed by the inkjet dispenser and form the nanoparticles therein.Type: ApplicationFiled: September 15, 2005Publication date: March 15, 2007Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Po-Fu Chou, Pei Kan, Chun Jung Chen, Shih-Liang Yang, Chun Fu Leu, Shin-San Su
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Patent number: 6849716Abstract: The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.Type: GrantFiled: August 18, 2000Date of Patent: February 1, 2005Assignee: Vertex Pharmaceuticals IncorporatedInventors: Michael Shin-San Su, Ted Fox, Keith Philip Wilson, Ursula A. Germann
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Publication number: 20040259166Abstract: The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.Type: ApplicationFiled: July 15, 2004Publication date: December 23, 2004Inventors: Michael Shin-San Su, Ted Fox, Keith Philip Wilson, Ursula A. Germann
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Publication number: 20030165899Abstract: The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.Type: ApplicationFiled: June 12, 2002Publication date: September 4, 2003Applicant: Vertex Pharmaceuticals, Inc.Inventors: Michael Shin-San Su, Ted Fox, Keith Philip Wilson, Ursula A. Germann
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Publication number: 20030163834Abstract: The invention relates to transgenic non-human animals, embryos and isolated cells therefrom that are heterozygous or homozygous for a mutation in the extracellular signal regulated kinase, Erk5, gene. Such animals, embryos and cells express Erk5 at a reduced level or not at all. Analysis of the homozygous embryos demonstrates a lack of vasculature, indicating that Erk-5 plays a role in angiogenesis. Thus, the present invention also relates to methods for temporarily decreasing or eliminating angiogenesis in a mammal by administering an agent which inhibits Erk-5 expression or Erk-5 activity. And the present invention also relates to methods for increasing angiogenesis in a mammal by administering a functional Erk5 gene.Type: ApplicationFiled: June 22, 2001Publication date: August 28, 2003Inventors: Keisuke Kuida, Michael Shin-San Su, Li Wei
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Publication number: 20030097669Abstract: The invention relates to transgenic non-human animals, embryos and isolated cells therefrom that are heterozygous or homozygous for a mutation in the extracellular signal regulated kinase, Erk5, gene. Such animals, embryos and cells express Erk5 at a reduced level or not at all. Analysis of the homozygous embryos demonstrates a lack of vasculature, indicating that Erk-5 plays a role in angiogenesis. Thus, the present invention also relates to methods for temporarily decreasing or eliminating angiogenesis in a mammal by administering an agent which inhibits Erk-5 expression or Erk-5 activity. And the present invention also relates to methods for increasing angiogenesis in a mammal by administering a functional Erk5 gene.Type: ApplicationFiled: August 3, 2001Publication date: May 22, 2003Inventors: Keisuke Kuida, Michael Shin-San Su, Li Wei
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Patent number: 6225350Abstract: This invention relates to the use of butyrate prodrugs derived from lactic acid for treating inflammatory bowel disease. The invention also relates to the use of those prodrugs for the treatment of a chemotherapy-induced mucocutaneous side effect in a patient. The invention further relates to the use of butyrate prodrugs for treating lung, colo-rectal or prostate cancer. And the invention also relates to the use of butyrate prodrugs to treat cystic fibrosis and to enhance the efficiency of gene therapy.Type: GrantFiled: September 10, 1999Date of Patent: May 1, 2001Assignee: Vertex Pharmaceuticals, Inc.Inventors: Roger Dennis Tung, Bigin Li, Michael Shin-San Su
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Patent number: 6162613Abstract: The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.Type: GrantFiled: February 18, 1998Date of Patent: December 19, 2000Assignee: Vertex Pharmaceuticals, Inc.Inventors: Michael Shin-San Su, Ted Fox, Keith Philip Wilson, Ursula A. Germann
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Patent number: 6008031Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.Type: GrantFiled: June 17, 1997Date of Patent: December 28, 1999Assignee: Duke UniversityInventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
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Patent number: 5861482Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.Type: GrantFiled: June 2, 1995Date of Patent: January 19, 1999Assignee: Duke UniversityInventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
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Patent number: 5858754Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.Type: GrantFiled: February 13, 1996Date of Patent: January 12, 1999Assignee: Duke UniversityInventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
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Patent number: 5702894Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.Type: GrantFiled: June 2, 1995Date of Patent: December 30, 1997Assignee: Duke UniversityInventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
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Patent number: 5679522Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.Type: GrantFiled: June 2, 1995Date of Patent: October 21, 1997Assignee: Duke UniversityInventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani Lee Cooper, Leroy Worth, Jr.
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Patent number: 5556750Abstract: A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.Type: GrantFiled: November 1, 1993Date of Patent: September 17, 1996Assignee: Duke UniversityInventors: Paul L. Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue, Deani L. Cooper, Leroy Worth, Jr.
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Patent number: 5459039Abstract: The present invention relates to a method for detecting base sequence differences within homologous regions of two DNA molecules comprising the steps of contacting at least one strand of the first DNA molecule with the complementary strand of the second DNA molecule under conditions such that base pairing occurs, contacting the resulting DNA duplexes with a protein that recognizes substantially all base pair mismatches under conditions such that the protein forms specific complexes with its cognate mispairs, and detecting the resulting DNA:protein complexes by a suitable analytical method. Also disclosed are protein components of DNA mismatch correction systems and the use of these components in methods for genetic mapping.Type: GrantFiled: March 18, 1994Date of Patent: October 17, 1995Assignee: Duke UniversityInventors: Paul Modrich, Shin-San Su, Karin G. Au, Robert S. Lahue