Patents by Inventor Shingo EIKAWA

Shingo EIKAWA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNE FUNCTION INSPECTION METHOD, CANCER PATIENT CATEGORIZATION METHOD, CANCER TREATMENT EFFICACY PREDICTION METHOD, AGENT FOR INCREASING INTRACELLULAR CALCIUM ION CONCENTRATION, AGENT FOR INCREASING SELECTIVE FUNCTION OF EFFECTOR MEMORY (EM) AND EFFECTOR (EFF) IN TUMOR TISSUE, AND METHOD FOR MONITORING EFFICACY OF CANCER DRUG
    Publication number: 20210223229
    Abstract: The present invention relates to an immune function inspection method, comprising obtaining peripheral blood from a human test subject; applying an immunostimulant; inspecting changes in intracellular calcium ion concentration in peripheral blood mononuclear cells (PBMC) or CD8T cells; determining a decrease in systemic immune function when the intracellular calcium ion concentration in PBMC or CD8T cells transiently increases after the application of the immunostimulant and then returns to the state before the stimulation; and determining normality of systemic immune function when the intracellular calcium ion concentration in PBMC or CD8T cells is in an upward trend after the application of the immunostimulant.
    Type: Application
    Filed: February 10, 2017
    Publication date: July 22, 2021
    Applicant: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventors: Heiichiro UDONO, Shingo EIKAWA
  • METHOD FOR ENHANCING IMMUNE CELL FUNCTION AND METHOD FOR ASSESSING IMMUNE CELL MULTIFUNCTIONALITY
    Publication number: 20170281569
    Abstract: The invention provides a method for enhancing immune cell function by activating various immune cells ex vivo and provides immune cells with enhanced function. The invention further provides an immune-related cell multifunctionality evaluation method. A biguanide antidiabetic drug selected from metformin, phenformin, and buformin is capable of enhancing immune cell multifunctionality by increasing CD8+T cells having a high ability to produce IL-2, INF?, and IFN?. The immune-related cell multifunctionality may be evaluated by comparing immune cells treated with a biguanide antidiabetic drug selected from metformin, phenformin, and buformin, with control immune cells untreated with the biguanide antidiabetic drug.
    Type: Application
    Filed: June 20, 2017
    Publication date: October 5, 2017
    Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, Ono Pharmaceutical Co., Ltd.
    Inventors: Heiichiro UDONO, Shingo EIKAWA, Shin-ichi TOYOOKA
  • METHOD FOR ENHANCING IMMUNE CELL FUNCTION AND METHOD FOR ASSESSING IMMUNE CELL MULTIFUNCTIONALITY
    Publication number: 20170231929
    Abstract: The present invention provides a method for enhancing immune cell function by activating various immune cells ex vivo and provides immune cells with enhanced function. The invention further provides an immune-related cell multifunctionality evaluation method. A biguanide antidiabetic drug selected from metformin, phenformin, and buformin is capable of enhancing immune cell multifunctionality by increasing CD8+T cells having a high ability to produce IL-2, INF?, and IFN?. The immune-related cell multifunctionality may be evaluated by comparing immune cells treated with a biguanide antidiabetic drug selected from metformin, phenformin, and buformin, with control immune cells untreated with the biguanide antidiabetic drug.
    Type: Application
    Filed: August 17, 2015
    Publication date: August 17, 2017
    Applicant: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventors: Heiichiro UDONO, Shingo EIKAWA, Shin-ichi TOYOOKA