Abstract: The present invention provides a hydrate of N-[(4S)-2-amino-2?,2?-dimethyldispiro[1,3-oxazole-4,4?-chromene-3?,3?-oxetan]-6?-yl]-5-chloropyridine-2-carboxamide which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by ?-secretase activity, hydrolysis of a ?-secretase site of a ?-amyloid precursor protein, and/or ?-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.

Abstract: The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by ?-secretase activity, hydrolysis of a ?-secretase site of a ?-amyloid precursor protein, and/or ?-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.

Abstract: A steel wire rod or steel bar as hot-rolled, including: by mass %: C: 0.1 to 0.6%, Si: 0.01 to 1.5%, Mn: 0.05 to 2.5%, Al: 0.015 to 0.3%, and N: 0.0040 to 0.0150%, and P: limited to 0.035% or less and S: limited to 0.025% or less, and the balance substantially consisting of iron and unavoidable impurities, wherein a depth of d (mm) from the surface of the surface layer region with 20 HV 0.2 or more higher, relative to HV 0.2 that is the average hardness in the region where the depth from the surface is from sectional radius R×0.5 (mm) to the center satisfies the formula (1); the steel structure of the surface layer region has a ferrite fraction of 10% or less by area ratio, with the balance being one or two or more of martensite, bainite and pearlite; the steel structure where the depth from the surface is from the sectional radius R×0.

Abstract: A high strength wire rod in which an area fraction of pro-eutectoid ferrite is 3% or less and an area fraction of pearlite structure is 90% or more, being obtained by subjecting a hard steel wire rod having specified composition to a molten salt patenting treatment directly after hot-rolling or after performing re-austenitization subsequent to hot-rolling.

Abstract: A wire material used for manufacturing a non-heat treated component whose tensile strength is 900 MPa to 1300 MPa, containing, in mass %: C: 0.20% to 0.50%, Si: 0.05% to 2.0%, Mn: 0.20% to 1.0%, being limited to contain P: 0.030% or less, S: 0.030% or less, N: 0.005% or less, F1 defined by the following expression (1) is less than 0.60, with the balance made up of Fe and inevitable impurities, wherein a metal structure contains a pearlite structure of 64×(C %)+52% or more in a volume fraction, with the balance made up of one kind or two kinds of a pro-eutectoid ferrite structure and a bainite structure, an average block grain diameter of the pearlite structure at a region from a surface layer to 0.1 D is 15 ?m or less when a diameter of the wire material is set to be D, and (the average block grain diameter of the pearlite structure at the region from the surface layer to 0.1 D)/(an average block grain diameter of the pearlite structure at a range from 0.25 D to a center) is less than 1.0.

Abstract: The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by ?-secretase activity, hydrolysis of a ?-secretase site of a ?-amyloid precursor protein, and/or ?-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.

Abstract: A steel wire rod which is a material of steel wires includes, as a metallographic structure, by area %, 95% to 100% of a pearlite, wherein an average pearlite block size at a central portion of the steel wire rod is 1 ?m to 25 ?m, an average pearlite block size at a surface layer portion of the steel wire rod is 1 ?m to 20 ?m, and, when a minimum lamellar spacing of the pearlite at the central portion of the steel wire rod is S in unit of nm and when a distance from a peripheral surface of the steel wire rod to a center is r in unit of mm, S<12 r+65 is satisfied.

Abstract: High performance high carbon wire with refined inclusions after wire rolling, extremely low wire breakage rates at the time of drawing even in tough applications, and excellent in fatigue characteristics after wire drawing, characterized by having a predetermined composition of ingredients and in that the number ratio of inclusions satisfying (% SiO2)=40 to 95%, (% CaO)=0.5 to 30%, (% Al2O3)=0.5 to 30%, (% MgO)=0.5 to 20%, and (% MnO)=0.5 to 10% and further satisfying (% Na)=0.2 to 7% and (% F)=0.17 to 8% (below, referred to as “inclusions covered due to composition”) in the oxide-based nonmetallic inclusions of a short axis of 0.5 ?m or more, a long axis of 1.0 ?m or more, and a circle equivalent diameter (area converted to diameter) of 1 ?m or more which are seen in the L direction cross-section of the wire (below, referred to as “inclusions covered due to size”), that is, the number of inclusions covered due to composition/number of inclusions covered due to size×100, is 80% or more.

Abstract: The invention provides a steel material with satisfactory hydrogen embrittlement resistance, and particularly it relates to high-strength steel with satisfactory hydrogen embrittlement resistance and a strength of 1200 MPa or greater, as well as a process for production thereof. At least one simple or compound deposit of oxides, carbides or nitrides as hydrogen trap sites which trap hydrogen with a specific trap energy is added to steel, where the mean sizes, number densities, and length-to-thickness ratios (aspect ratio) are in specific ranges. By applying the specific steel components and production process it is possible to obtain high-strength steel with excellent hydrogen embrittlement resistance.

Abstract: The present invention provides a wire rod with a composition at least including: C: 0.95-1.30 mass %; Si: 0.1-1.5 mass %; Mn: 0.1-1.0 mass %; Al: 0-0.1 mass %; Ti: 0-0.1 mass %; P: 0-0.02 mass %; S: 0-0.02 mass %; N: 10-50 ppm; O: 10-40 ppm; and a balance including Fe and inevitable impurities, wherein 97% or more of an area in a cross-section perpendicular to the longitudinal direction of the wire rod is occupied by a pearlite, and 0.5% or less of an area in a central area in the cross-section and 0.5% or less of an area in a first surface layer area in the cross-section are occupied by a pro-eutectoid cementite.

Abstract: The present invention provides a wire rod with a composition at least including: C: 0.95-1.30 mass %; Si: 0.1-1.5 mass %; Mn: 0.1-1.0 mass %; Al: 0-0.1 mass %; Ti: 0-0.1 mass %; P: 0-0.02 mass %; S: 0-0.02 mass %; N: 10-50 ppm; O: 10-40 ppm; and a balance including Fe and inevitable impurities, wherein 97% or more of an area in a cross-section perpendicular to the longitudinal direction of the wire rod is occupied by a pearlite, and 0.5% or less of an area in a central area in the cross-section and 0.5% or less of an area in a first surface layer area in the cross-section are occupied by a pro-eutectoid cementite.

Abstract: A predetermined composition is had, when a C content is represented by (C %), in a case of (C %) being not less than 0.35% nor more than 0.65%, a volume fraction of pearlite is 64×(C %)+52% or more, and in a case of (C %) being greater than 0.65% and 0.85% or less, the volume fraction of pearlite is not less than 94% nor more than 100%, and a structure of the other portion is composed of one or two of proeutectoid ferrite and bainite. Further, in a region to a depth of 1.0 mm from a surface, a volume fraction of pearlite block having an aspect ratio of 2.0 or more is not less than 70% nor more than 95%, and a volume fraction of pearlite having an angle between an axial direction and a lamellar direction on a cross section parallel to the axial direction of 40° or less is 60% or more with respect to all pearlite.

Abstract: The invention provides wire rod excellent in drawability and steel wire made from the wire rod as starting material with high productivity at good yield and low cost. A hard steel wire rod of a specified composition is hot rolled, the hot-rolled steel is coiled in a specified temperature range, and the coiled steel is subjected to patenting at a predetermined cooling rate, thereby affording a high-carbon steel wire excellent in workability. It is high-strength steel wire excellent in drawability comprising a pearlite structure of an area ratio of 97% or greater and the balance of non-pearlite structures including bainite, degenerate-pearlite and pro-eutectoid ferrite and having a pearlite block size of not less than 20 ?m and not greater than 45 ?m. The invention also provides a high-carbon steel wire excellent in ductility, which is manufactured by subjecting the wire rod to intermediate patenting and cold drawing and has a tensile strength of 2800 MPa or greater.

Abstract: To provide a compound which is useful as an NMDA receptor antagonist. The present inventors have studied a compound having an NMDA receptor antagonistic action, and confirmed that the fused indane compound of the present invention has an excellent NMDA receptor antagonistic action, thereby completed the present invention. The fused indane compound of the present invention has an excellent NMDA receptor antagonistic action and can be used as a prophylactic and/or therapeutic agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, intractable depression, attention deficit hyperactivity disorder, migraines, or the like.

Abstract: The invention provides wire rod excellent in drawability and steel wire made from the wire rod as starting material with high productivity at good yield and low cost. A hard steel wire rod of a specified composition is heated in a specified temperature range to conduct post-reaustenization patenting and thereby obtain a high-carbon steel wire excellent in ductility that has a pearlite structure of an area ratio of 97% or greater and the balance of non-pearlite structures including bainite, degenerate-pearlite and pro-eutectoid ferrite and whose fracture reduction of area RA satisfies Expressions (1), (2) and (3) below: RA?RAmin??(1), where RAmin=a?b×pearlite block size (?m), a=?0.0001187×TS (MPa)2+0.31814×TS (MPa)?151.32??(2) b=0.0007445×TS (MPa)?0.3753??(3).

Abstract: A wire rod which is mainly composed of pearlite and has an area fraction of 5% or less of a non-pearlite structure composed of pro-eutectoid ferrite, degenerate-pearlite or bainite in a section, or has an area fraction of 10% or less of a non-pearlite structure in a portion from the surface to a depth of 100 ?m.

Abstract: Disclosed is a high-strength Zn—Al coated steel wire for bridges with excellent corrosion resistance and fatigue properties, the Zn—Al coated steel wire includes: a steel wire; and a Zn—Al coating having a coating body layer and an Fe—Al alloy layer formed in an interface between a surface layer of the steel wire and the coating body layer, wherein a chemical composition of a core material of the steel wire includes, by mass %: C: 0.70% to 1.2%; Si: 0.01% to 2.5%; Mn: 0.01% to 0.9%; P: limited to 0.02% or less; S: limited to 0.02% or less; N: limited to 0.01% or less; and the balance including Fe and unavoidable impurities, wherein wire-drawn pearlite is most abundant microstructure among microstructures of the core material of the steel wire; wherein an average composition of the Zn—Al coating includes, by mass %, Al: 3.0 to 15.0%; and Fe: limited to 3.0% or less, and wherein the Fe—Al alloy layer has a thickness of 5 ?m or less.

Abstract: A plated steel wire for PWS with excellent twist properties contains, in terms of mass %, 0.8 to 1.1% of C, 0.8 to 1.3% of Si, 0.3 to 0.8% of Mn, 0.001 to 0.006% of N, and 0.0004 to 0.0060% of B, where a quantity of solid-solubilized B is at least 0.0002%, also contains either one or both of 0.005 to 0.1% of Al and 0.005 to 0.1% of Ti, and contains as the remainder, Fe and unavoidable impurities, wherein an area fraction of non-pearlite structures in a region from a surface layer down to a depth of 50 ?m is not more than 10%, an area fraction of non-pearlite structures within an entire cross-section is not more than 5%, and a surface of the steel wire is galvanized with a plating quantity within a range from 300 to 500 g/m2.

Abstract: The present invention provides a wire rod with a composition at least including: C: 0.95-1.30 mass %; Si: 0.1-1.5 mass %; Mn: 0.1-1.0 mass %; Al: 0-0.1 mass %; Ti: 0-0.1 mass %; P: 0-0.02 mass %; S: 0-0.02 mass %; N: 10-50 ppm; O: 10-40 ppm; and a balance including Fe and inevitable impurities, wherein 97% or more of an area in a cross-section perpendicular to the longitudinal direction of the wire rod is occupied by a pearlite, and 0.5% or less of an area in a central area in the cross-section and 0.5% or less of an area in a first surface layer area in the cross-section are occupied by a pro-eutectoid cementite.

Abstract: A high-carbon steel wire rod of high ductility for steel cord and the like is provided that experiences little breakage during drawing. The high-carbon steel wire rod of high ductility is a high-carbon steel wire rod fabricated by hot rolling that that has a carbon content of 0.7 mass % or greater, wherein 95% or greater of the wire rod metallographic structure is pearlite structure and the maximum pearlite block size of pearlite at the core of the hot-rolled wire rod is 65 ?m or less. The high-carbon steel wire rod of high ductility has a tensile strength in a range of {248+980×(C mass %)}±40 MPa} and a reduction of area of {72.8?40×(C mass %) %} or greater. The high-carbon steel wire rod of high ductility is characterized in that the average pearlite block size at the core of the hot-rolled wire rod constituted by ferrite grain boundaries of an orientation difference of 9 degrees or greater as measured with an EBSP analyzer is 10 ?m or greater and 30 ?m or less.