Abstract: Coordinates of a first region extraction window, a first sample stage coordinate, a second sample stage coordinate, and a second region extraction window, including images of one sample stage and an observation target tissues of a sample when the one sample stage is respectively positioned on two microscopes are respectively obtained. Based on difference between the first sample stage coordinate and the second sample stage coordinate, the second sample stage coordinate is corrected. Based on the obtained corrected second sample stage coordinate, the second positioning unit is moved from the second non-observation position to the second observation position where the second region extraction window is located at a position corresponding to the coordinate position of the first region extraction window.

Abstract: Coordinates of a first region extraction window, a first sample stage coordinate, a second sample stage coordinate, and a second region extraction window, including images of one sample stage and an observation target tissues of a sample when the one sample stage is respectively positioned on two microscopes are respectively obtained. Based on difference between the first sample stage coordinate and the second sample stage coordinate, the second sample stage coordinate is corrected. Based on the obtained corrected second sample stage coordinate, the second positioning unit is moved from the second non-observation position to the second observation position where the second region extraction window is located at a position corresponding to the coordinate position of the first region extraction window.

Abstract: Provided is an alkoxysilyl group-containing organic EL dye that can be used for the production of fluorescent silica particles that do not fade. This alkoxysilyl group-containing organic EL dye is represented by the general formula X—Y-Q-Z—Si(R1)n(OR2)3-n, wherein X is an organic EL dye, Y is a direct bond or —(CH2)p— (p represents an integer from 1 to 10) or —(O—CH2CH2)q— (q represents an integer from 1 to 10), Q is a bond selected from the group consisting of amide bond, ether bond, thioether bond, thioester bond, thiourea bond, disulfide bond, and polyoxyethylene bond, Z is —(CH2)3— or —(CH2)2NH(CH2)3—, R1 and R2 represent an alkyl group having 1 to 7 carbon atoms, and n represents 0 or 1.

Abstract: There is provided a fluorescent dye which can improve the fluorescent intensity at the time of labeling to thereby detect a biomolecule with higher sensitivity. The fluorescent dye of the present invention includes a nitrogen cation-containing group or a nitrogen-containing group. Its high water solubility can improve the rate of labeling for a biomolecule to thereby detect a biomolecule with high sensitivity.

Abstract: There is provided a fluorescent dye which can improve the fluorescent intensity at the time of labeling to thereby detect a biomolecule with higher sensitivity. The fluorescent dye of the present invention includes a nitrogen cation-containing group or a nitrogen-containing group. Its high water solubility can improve the rate of labeling for a biomolecule to thereby detect a biomolecule with high sensitivity.

Abstract: Provided is a multiple light source microscope which is capable of performing not only electron image observation but also fluorescence image observation, fluoroscopic image observation and the like for the same biological tissue sample, and is provided with a plurality of observation-use light sources. Disclosed is this multiple light source microscope configured by: an optical microscope unit for observing fluorescence, provided with a light source unit; and a scanning electron microscope unit, wherein the optical microscope has a Cassegrain mirror with an aspherical reflecting surface, and the Cassegrain mirror is arranged in a lens barrel of the scanning microscope unit so as to be coaxial with an optical axis of an electron beam of the scanning electron microscope unit.

Abstract: A red fluorescence conversion composition includes a color conversion material (A) which absorbs light in a blue region and emits light having a fluorescence emission maximum in yellow-orange regions; a color conversion material (B) which absorbs light in the yellow-orange regions and emits light having a fluorescence emission maximum in the red region; and a matrix resin (C) for dispersing the color conversion materials (A) and (B). The color conversion material (A) is a condensed polycyclic compound made of a 5-membered ring compound having a conjugated system, and a 6-membered ring compound having a conjugated system with the 5-membered ring compound. The 5-membered ring compound contains at least one kind of atom selected from a hetero atom, a selenium atom, and a boron atom. A red fluorescence conversion film is made of the composition.

Abstract: A labeling dye of the present invention includes a coloring portion comprising an organic EL-dye, a bonding portion to be bonded with a biomolecule and a spacer portion for linking the coloring portion and the bonding portion. The present invention provides a high incorporation ratio and also high fluorescence intensity in solid state.

Abstract: Disclosed is an organic EL dye enabling to provide an organic EL device which is capable of emitting a light at a low voltage even when it has a single layer structure. Also disclosed is an organic EL device using such an organic EL dye. The organic EL dye is represented by the general formula (1): (Y—L)nXm wherein x is an n-valent charge-transporting group, Y is a light-emitting group, L is a linking group bonding the charge-transporting group and the light-emitting group, and m and n are respectively an integer not less than 1.

Abstract: A labeling dye of the present invention includes a coloring portion comprising an organic EL-dye, a bonding portion to be bonded with a biomolecule and a spacer portion for linking the coloring portion and the bonding portion. The present invention provides a high incorporation ratio and also high fluorescence intensity in solid state.

Abstract: The present invention provides a method for detecting a biomolecule. The method includes reacting a biomolecule sample with an organic EL-dye and measuring the fluorescence of the biomolecule sample labeled with the organic EL-dye. The method provides a highly sensitive method of detecting a biomolecule at lower cost.

Abstract: The present invention provides a method for detecting a biomolecule. The method includes reacting a biomolecule sample with an organic EL-dye and measuring the fluorescence of the biomolecule sample labeled with the organic EL-dye. The method provides a highly sensitive method of detecting a biomolecule at lower cost.

Abstract: Disclosed is an organic EL dye enabling to provide an organic EL device which is capable of emitting a light at a low voltage even when it has a single layer structure. Also disclosed is an organic EL device using such an organic EL dye. The organic EL dye is represented by the general formula (1): (Y—L)nXm wherein x is an n-valent charge-transporting group, Y is a light-emitting group, L is a linking group bonding the charge-transporting group and the light-emitting group, and m and n are respectively an integer not less than 1.

Abstract: The present invention provides a method of detecting a biological molecule. The method includes reacting a biological molecule sample with an organic EL-dye and measuring the fluorescence of the biological molecule sample labeled with the organic EL-dye. The method provides a highly sensitive method of detecting a biological molecule at lower cost.

Abstract: The present invention provides a method of detecting a biological molecule. The method includes reacting a biological molecule sample with an organic EL-dye and measuring the fluorescence of the biological molecule sample labeled with the organic EL-dye. The method provides a highly sensitive method of detecting a biological molecule at lower cost.