Abstract: The present disclosure provides and an agent for treating or preventing an eye disease such as presbyopia, comprising, as an active ingredient, a lipoic acid prodrug having a specified structure.

Abstract: Provided are agents for prevention and therapeutic treatment of cataract that act by a different mechanism from conventional agents, and use of a PPAR activator for production of such agents. An agent for prevention and/or therapeutic treatment of cataract, containing a PPAR activator as an active ingredient, is used.

Abstract: The present invention relates to defined quinoxalin-2-one compounds or a pharmaceutically acceptable salt or a hydrate or a solvate thereof. The compounds, salts or hydrates have a glucocorticoid receptor agonist activity, and are useful as a medicine, in particular as a prophylactic or therapeutic agent for a glucocorticoid receptor related disease.

Abstract: The present invention relates to defined quinoxalin-2-one compounds or a pharmaceutically acceptable salt or a hydrate or a solvate thereof. The compounds, salts or hydrates have a glucocorticoid receptor agonist activity, and are useful as a medicine, in particular as a prophylactic or therapeutic agent for a glucocorticoid receptor related disease.

Abstract: The present invention relates to defined quinoxalin-2-one compounds or a pharmaceutically acceptable salt or a hydrate or a solvate thereof. The compounds, salts or hydrates have a glucocorticoid receptor agonist activity, and are useful as a medicine, in particular as a prophylactic or therapeutic agent for a glucocorticoid receptor related disease.

Abstract: The present invention relates to a novel [4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or a salt thereof. The compound or a salt thereof of the present invention has a glucocorticoid receptor agonist activity, and is useful as a medicine, in particular as a prophylactic or therapeutic agent for the glucocorticoid receptor related disease.

Abstract: The present invention relates to a novel [4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or a salt thereof. The compound or a salt thereof of the present invention has a glucocorticoid receptor agonist activity, and is useful as a medicine, in particular as a prophylactic or therapeutic agent for the glucocorticoid receptor related disease.

Abstract: A coated steel sheet comprises: a steel sheet; a primer coating film which is arranged on the steel sheet and comprises an anti-corrosive pigment and an aggregate composed of primary particles; and a top coating film which is arranged on the primer coating film. The anti-corrosive pigment comprises at least one compound selected from the group consisting of a bivalent tin salt, a trivalent vanadium salt, a tetravalent vanadium salt, a tetravalent molybdenum salt, an oxycarboxylic acid salt, an ascorbic acid, a phosphorous acid salt and a hypophosphorous acid salt.

Abstract: This coated steel sheet comprises: a steel sheet; a primer coating film that is arranged on the steel sheet and contains a chromic acid-based rust preventive pigment and aggregate that serves as primary particles, while not containing porous particles; and a top coating film that is arranged on the primer coating film. The aggregate satisfies the following formula (1) and formula (2). D10?0.6T (1) D90<2.0T (2) (In the formulae, D10 represents the 10% particle diameter (?m) of the aggregate in the number-based cumulative particle size distribution; D90 represents the 90% particle diameter (?m) of the aggregate in the number-based cumulative particle size distribution; and T represents the film thickness (?m) of a portion of the primer coating film, in which the aggregate is not present.

Abstract: A coated steel sheet comprises: a steel sheet; a primer coating film which is arranged on the steel sheet and comprises an anti-corrosive pigment and an aggregate composed of primary particles; and a top coating film which is arranged on the primer coating film. The anti-corrosive pigment comprises at least one compound selected from the group consisting of a bivalent tin salt, a trivalent vanadium salt, a tetravalent vanadium salt, a tetravalent molybdenum salt, an oxycarboxylic acid salt, an ascorbic acid, a phosphorous acid salt and a hypophosphorous acid salt.

Abstract: A compound represented by the following general formula (1) or a salt thereof. R1 represents a halogen atom and so on; R2 and R3 each represent a hydrogen atom and so on; R4 and R5 each represent a hydrogen atom and so on, or R4 and R5 may form an oxo group; Ra and Rb each represent a lower alkyl group optionally having a substituent and so on, or they may bind to each other to form a nitrogen-containing heterocyclic ring which may be substituted by one or plural Rc; Rc represents an aryl group optionally having a substituent and so on; ring A represents a benzene ring and so on; and m represents 0, 1 or 2.

Abstract: A compound represented by the following general formula (1) or a salt thereof. R1 represents a halogen atom and so on; R2 and R3 each represent a hydrogen atom and so on; R4 and R5 each represent a hydrogen atom and so on, or R4 and R5 may form an oxo group; Ra and Rb each represent a lower alkyl group optionally having a substituent and so on, or they may bind to each other to form a nitrogen-containing heterocyclic ring which may be substituted by one or plural Rc; Rc represents an aryl group optionally having a substituent and so on; ring A represents a benzene ring and so on; and m represents 0, 1 or 2.

Abstract: The hot rolling apparatus of the present invention has a mill arranged on the preceding stage, mills of a plurality of stands arranged on the later stage which are different-diameter roll mills including a pair of different-diameter work rolls having an equivalent roll diameter of less than 600 mm or minimum-diameter roll mills including a pair of work rolls having a diameter of less than 600 mm, and a cooling unit for cooling steel to be rolled which is arranged on each exit side of the mills of at least two stands on the later stage. The hot rolling apparatus can smoothly manufacture hot rolled plates of fine-particle steel.

Abstract: A continuous hot-rolling mill includes an upper rolling unit including a plurality of rolling stands, and a lower rolling unit including a plurality of rolling stands and disposed downstream with respect to the upper rolling unit in a workpiece passing direction in which a workpiece to be rolled is passed. The two or more rolling stands of the lower rolling unit are differential or very-small-diameter rolling stands. Each of the two or more differential or very-small-diameter rolling stands of the lower rolling unit is provided with a drive motor having a capacity greater than that of any one of drive motors included in the rolling stands disposed upstream the differential or very-small-diameter rolling stands. The continuous hot-rolling mill is suitable for producing hot-rolled, fine-grained steel sheets and is excellent in sheet passing abilities for preventing the steel sheet from meandering and for rolling the steel sheet in a desired shape.

Abstract: A sheet rolling method uses a rolling mill (10) for rolling a sheet (x). The rolling mill (10) includes upper and lower backup rolls (13, 14), and a pair of work rolls (11, 12) respectively having different diameters and disposed between the upper and the lower backup roll (13, 14). A small-diameter work roll (11) of the pair of work rolls is disposed so that a rotational axis thereof is positioned on a mill center or a downstream side with respect to the mill center in a rolling direction, and the large-diameter work roll (12) is disposed so that a rotational axis thereof is positioned on a downstream side with respect to the rotational axis of the small-diameter work roll (11) in the rolling direction. Thus, mechanical load on the work rolls (11, 12) can be reduced even when a high rolling force is necessary for rolling a wide sheet.

Abstract: The hot rolling apparatus of the present invention has a mill arranged on the preceding stage, mills of a plurality of stands arranged on the later stage which are different-diameter roll mills including a pair of different-diameter work rolls having an equivalent roll diameter of less than 600 mm or minimum-diameter roll mills including a pair of work rolls having a diameter of less than 600 mm, and a cooling unit for cooling steel to be rolled which is arranged on each exit side of the mills of at least two stands on the later stage. The hot rolling apparatus can smoothly manufacture hot rolled plates of fine-particle steel.

Abstract: A sheet rolling method uses a rolling mill (10) for rolling a sheet (x). The rolling mill (10) includes upper and lower backup rolls (13, 14), and a pair of work rolls (11, 12) respectively having different diameters and disposed between the upper and the lower backup roll (13, 14). A small-diameter work roll (11) of the pair of work rolls is disposed so that a rotational axis thereof is positioned on a mill center or a downstream side with respect to the mill center in a rolling direction, and the large-diameter work roll (12) is disposed so that a rotational axis thereof is positioned on a downstream side with respect to the rotational axis of the small-diameter work roll (11) in the rolling direction. Thus, mechanical load on the work rolls (11, 12) can be reduced even when a high rolling force is necessary for rolling a wide sheet.