Abstract: An object of the present invention is to provide an anticancer drug capable of treating cancer by finding a target molecule specifically expressed in cancer cells and by specifically acting on the target molecule, and to provide a cancer testing method including a step of measuring the target molecule in a sample. The present invention provides an anticancer drug containing, as an active ingredient thereof, an anti-transmembrane protein 180 (TMEM-180) antibody or an antigen-binding fragment thereof. In addition, the present invention provides a cancer testing method including a step of measuring the amount of TMEM-180 in a sample collected from a subject.

Abstract: A system includes a memory that stores a trained model and a processor. The processor acquires a captured image in which at least one energy device and at least one biological tissue are imaged. The processor performs a process based on the trained model stored in the memory to estimate a heat diffusion region and a specific tissue region from the captured image. The processor determines a risk for heat damage on a specific tissue by energy output from the energy device from the estimated heat diffusion region and the estimated specific tissue region.

Abstract: The system includes a memory that stores first and second trained models, and a processor. The processor acquires a captured image in which at least one energy device and at least one biological tissue are imaged. The processor detects a bounding box from the captured image by processing based on the first trained model and estimates the image recognition information from the captured image in the bounding box by processing based on the second trained model. The processor outputs an energy output adjustment instruction based on the estimated image recognition information to the generator. The generator controls the energy supply amount to the energy device based on the energy output adjustment instruction.

Abstract: A treatment-energy applying structure includes a flexible substrate having a wiring pattern having a heat-generation region and a connection region. A heat transfer plate faces a surface of the flexible substrate, and transfers heat to a body tissue. An adhesive sheet, having heat conductivity, is disposed between the flexible substrate and the heat transfer plate to cover the entirety of the heat-generation region and the heat transfer plate. A region of the adhesive sheet protrudes from the heat transfer plate to cover a region of the connection region. A pair of lead wires connects to the connection region outside of the covered region. The adhesive sheet is longer than the heat transfer plate and shorter than the flexible substrate. A gap between an end of the heat transfer plate and the lead wires is longer than a diameter of the lead wires or a thickness of the heat transfer plate.

Abstract: A treatment tool includes: a first jaw including a first holding surface; a second jaw including a second holding surface; a first wiring pattern that includes a first heat-generating portion; a first heating plate; a second wiring pattern that includes a second heat-generating portion; and a second heating plate. The first heat-generating portion is provided at a first area when the first holding surface is divided into two areas where the first area and a second area are arranged, and the second heat-generating portion is provided at a second projection area when the second holding surface is divided into two areas where a first projection area onto which the first area is projected and the second projection area onto which the second area is projected in a closed state where the first holding surface and the second holding surface are faced each other.

Abstract: An ultrasound medical apparatus includes an ultrasound transducer configured to generate ultrasound vibration, a vibration transmitting member including a contact surface configured to contact a biological tissue, a high heat conductive member placed in a center of the contact surface, and a low heat conductive member placed around the high heat conductive member, and configured to transmit the ultrasound vibration to the biological tissue, and a control apparatus configured to control drive of the ultrasound transducer to a first mode of driving at a first resonance frequency of the ultrasound transducer, and a second mode of driving at a second resonance frequency of a structure provided with the ultrasound transducer and the vibration transmitting member.

Abstract: An ultrasound medical device includes: a treatment portion configured to treat a living tissue; and a piezoelectric transducer unit provided in the treatment portion and formed by laminating a plurality of piezoelectric elements, which is configured to excite ultrasound vibration, and a plurality of insulating layers and bonding each of the piezoelectric elements and the insulating layers through bonding layers. A thickness of each of the piezoelectric elements, the insulating layers, and a plurality of the bonding layers is set such that nodes of the ultrasound vibration are located other than in the bonding layers.

Abstract: A living tissue to be treated is brought into contact with a first high-frequency electrode having high thermal conductivity. A substrate on which an electric resistance pattern is formed is longer than the first electrode. The substrate includes an end portion projected from the first high-frequency electrode. A first lead connection portion electrically connected to the electric resistance pattern is formed on the projected end portion. The substrate is pasted to the first electrode by use of a high-thermal-conductivity heat-resistant adhesive sheet. A lead line for applying power to the electric resistance pattern is arranged in the first lead connection portion where it extends in the longitudinal direction of the first electrode and on the side close to the first electrode.

Abstract: A medical treatment apparatus includes a heat transfer portion, a heating chip, a temperature measurement unit and a control unit. The heat transfer portion comes into contact with a living tissue and transfers heat to the living tissue. The heating chip includes a heating region, is joined to the heat transfer portion, and heats the heat transfer portion by inputting energy to the heating region. The temperature measurement unit acquires a temperature of the heating region. The control unit controls a temperature of the heat transfer portion to a target temperature by controlling the temperature of the heating region to a temperature differing from the target temperature by an offset value which changes in accordance with an amount of the energy.

Abstract: A treatment-energy applying structure includes a flexible substrate having a wiring pattern having a heat-generation region and a connection region. A heat transfer plate faces a surface of the flexible substrate, and transfers heat to a body tissue. An adhesive sheet, having heat conductivity, is disposed between the flexible substrate and the heat transfer plate to cover the entirety of the heat-generation region and the heat transfer plate. A region of the adhesive sheet protrudes from the heat transfer plate to cover a region of the connection region. A pair of lead wires connects to the connection region outside of the covered region. The adhesive sheet is longer than the heat transfer plate and shorter than the flexible substrate. A gap between an end of the heat transfer plate and the lead wires is longer than a diameter of the lead wires or a thickness of the heat transfer plate.

Abstract: A therapeutic treatment device including: a heat conduction plate including a first major surface and a second major surface opposite to each other and configured to apply heat to a living tissue, with the first major surface kept in contact with the living tissue; an electric resistance pattern formed on an insulative substrate and configured to generate heat upon application of power; and an adhesive sheet which adheres the second major surface of the heat conduction plate and the electric resistance pattern to each other and is configured to transfer the heat generated by the electric resistance pattern to the heat conduction plate. A method of manufacturing including: forming the electric resistance pattern on the insulative substrate; stacking the heat conduction plate, the insulative substrate and the adhesive sheet; and joining the heat conduction plate, the adhesive sheet and the insulative substrate, by hot pressing.

Abstract: A treatment device for a medical treatment heats a biotissue. The device includes first and second heat transfer portions which come in contact with the biotissue. The device includes first and second resistance elements which are supplied a power having a first power value and a second power value to heat the first heat transfer portion and second heat transfer portion, respectively. The device includes temperature acquiring section which acquires a first temperature of the first heat transfer portion. The device includes a control section which calculates the first power value based on the first temperature, and determines the second power value corresponding to the first power value. The device includes first and second power supplying sections which supply the power having the first and second power value to the first and second resistance elements, respectively.

Abstract: A treatment device for a medical treatment heats a biotissue. The device includes a treatment tool which includes a heat transfer portion and a resistance element, a storage section which stores a time-power list including time-power relations, and a controller. The controller includes a resistance value acquiring section acquiring a resistance value of the resistance element, a power supplying section supplying the power to the resistance element, and a control section. The control section causes the power supplying section to supply a predetermined state detection power in a state detection period, calculates a change of the resistance value in the state detection period, acquires the time-power relation corresponding to the change of the resistance value, and causes the power supplying section to supply the power based on the acquired time-power relation.

Abstract: A treatment device for a medical treatment heats a biotissue at a desired temperature, and includes a treatment tool, a controller and a storage section. The treatment tool includes a heat transfer portion which contacts with the biotissue to transfer heat to the biotissue, and a resistance element into which power is supplied to heat the heat transfer portion. The controller is detachably attached to the treatment tool, and measures a resistance value R of the resistance element. The storage section stores a coefficient C2. The controller calculates a coefficient C1 based on a calibration temperature when the treatment tool is connected to the controller. The controller calculates a temperature of the resistance element using the R, C1 and C2, and controls the temperature of the heat transfer portion.

Abstract: A treatment device treats a biotissue by heating the biotissue to a target temperature. The device includes a heat-transfer member conveying heat to the biotissue, a heat-generating chip including a heat-generating member, a first temperature-measuring module, a temperature-measuring element disposed on the heat-transfer member, a second temperature-measuring module, and a controller. The heat-generating member heats the heat-transfer member. The first temperature-measuring module obtains a first temperature of the heat-generating member. The second temperature-measuring module obtains a second temperature measured by the temperature-measuring element. The controller determines the supplied electric power based on the first temperature after start of heating and before a transition point in time, and based on the second temperature after the transition point in time.

Abstract: A pump unit which can be made to be small-sized, and which enables to achieve a sufficient flow and an endoscope apparatus using such pump are provided. The pump unit which transports a fluid in a channel upon generating a progressive wave which is propagated in a longitudinal direction of the channel, in a first flexible thin film which constitutes at least a part of a channel-wall surface, includes a vibration exciter unit.

Abstract: A surgical treatment system include a pair of holding members holding a living tissue and a plurality of heater members disposed on at least one of the holding members. The surgical treatment system further includes a resistance pattern which transfer heat to the living tissue, a pair of electrodes disposed at opposite ends of the resistance pattern to generate the heat based on a energy to supply the heat to the resistance pattern, wires each connecting one of the heater members to another heater member and heater member energization line connected to the wire and to a energy source to supply the energy from the energy source to the electrodes via the wire.

Abstract: An endoscope fogging prevention system includes a heater which heats inside of a distal end portion, a temperature sensor which measures heat quantity information regarding the inside and a control unit which controls the driving of the heater based on the heat quantity information measured by the temperature sensor. The fogging prevention system judging the operating characteristics of the heater and the operating characteristics of the temperature sensor based on the heat quantity information, and deactivating the heater when judging that the judgment result is out of a desired range.

Abstract: A living tissue to be treated is brought into contact with a first high-frequency electrode having high thermal conductivity. A substrate on which an electric resistance pattern is formed is longer than the first electrode. The substrate includes an end portion projected from the first high-frequency electrode. A first lead connection portion electrically connected to the electric resistance pattern is formed on the projected end portion. The substrate is pasted to the first electrode by use of a high-thermal-conductivity heat-resistant adhesive sheet. A lead line for applying power to the electric resistance pattern is arranged in the first lead connection portion where it extends in the longitudinal direction of the first electrode and on the side close to the first electrode.

Abstract: Provided is a living body information acquisition apparatus comprising a sensor configured to acquire living body information of an inside of a subject, and a power supply apparatus comprising a power supply circuit configured to be able to wirelessly supply power necessary for driving the sensor of the living body information acquisition apparatus, wherein the living body information acquisition apparatus further comprises a power receiving circuit configured to receive power supplied from the power supply circuit and an extension part that is provided so as to extend from a main body part of the living body information acquisition apparatus, and is formed from a flexible member which can contain thereinside at least a part of the power receiving circuit.