Abstract: A charged particle beam device 1 includes analysis means performed by a controller when a sample holder HL holding a sample SAM is installed on a stage 23. The analysis means includes a step (a) of raising a degree of vacuum of each of an observation chamber 10 and a preprocessing chamber 20 by opening a gate valve VL5, opening a valve VL1, closing a valve VL2, and driving a vacuum pump 40, a step (b) of closing the gate valve VL5 and opening the valve VL2 after the step (a), and a step (c) of processing the sample SAM by radiating an ion beam from an ion source 22 to the sample SAM while performing vacuum exhaust of the preprocessing chamber 20 by the vacuum pump 40 after the step (b). The analysis means can process the sample SAM quickly after performing the vacuum exhaust of the preprocessing chamber 20 in a short time.

Abstract: An object of the present invention is to provide an anti-BMP10 antibody, and a therapeutic agent for hypertension and a hypertensive disease, containing the antibody as an active ingredient. The present invention relates to an anti-BMP10 monoclonal antibody or an antibody fragment thereof that binds to human BMP10 (bone morphogenetic protein 10). Further, the present invention relates to a therapeutic agent for hypertension and a hypertensive disease containing an antagonist for at least one of BMP10 and a BMP9/BMP10 heterodimer, a diagnostic agent or a pharmaceutical composition for a disease associated with human BMP10, an immunological detection method or a measurement method for human BMP10 using the antagonist, and use of the antagonist for producing a pharmaceutical composition for treating hypertension and a hypertensive disease.

Abstract: A composite charged particle beam apparatus includes a first charged particle beam column that irradiates a thin sample with a first charged particle beam, and a second charged particle beam column that irradiates an irradiation position of the first charged particle beam on the thin sample with a second charged particle beam. A sample holder as a base stage disposed on a sample stage, a motor-driven rotation driving section, a rotation stand rotatable about a flip axis by the driving of the rotation driving section, and a TEM grid that holds the thin sample. The TEM grid is movable within a plane perpendicular to an observation surface of the thin sample together with the rotation stand by being reciprocally driven around the flip axis by the driving section.

Abstract: A book block supplying machine includes a reader which reads job information from an information portion printed on a book block; and a timing adjusting portion which adjusts a supply timing at which the book block is fed toward the book binding machine. A controller includes: a job information acquisition portion which acquires the job information; an upper limit processing speed acquisition portion which acquires an upper limit processing speed; a making speed decision portion which adopts and decides the making speed; a making speed instruction portion which instructs the book binding machine to make the bound material at the making speed; a timing decision portion which decides the supply timing based on the making speed, upper limit processing speed and accumulating number; and a timing instruction portion which instructs the timing adjusting portion to supply the book block at the supply timing.

Abstract: The device includes a first conveyor 1 and a second conveyor 12. The first conveyor transports the book blocks B to the bookbinding apparatus and can accumulate the book blocks on a transport surface 4. A first stopper 23 is arranged at an entrance of the second conveyor and a second stopper 28 is arranged in the middle of a path of book block on the transport surface of the first conveyor. The first and second stoppers can take a block position and a retracted position. The second conveyor and the first stopper operate in synchronization with an operation of the bookbinding apparatus. The second stopper takes the block position when the number of book blocks accumulated on upstream side of the first stopper exceeds a predetermined limit value, or when a thickness difference between the book blocks transported side by side exceeds a predetermined reference value.

Abstract: The cutting machine for cutting a paper, comprising: a conveying section configured to convey the paper one by one in a conveying direction; a rotating section configured to rotate the paper conveyed by the conveying section 2; and a downstream cutting section disposed on a downstream side of the rotating section in the conveying direction 1a, including at least one cutter, and configured to cut the paper rotated by the rotating section in the conveying direction 1a.

Abstract: The device includes a first conveyor 1 and a second conveyor 12. The first conveyor transports the book blocks B to the bookbinding apparatus and can accumulate the book blocks on a transport surface 4. A first stopper 23 is arranged at an entrance of the second conveyor and a second stopper 28 is arranged in the middle of a path of book block on the transport surface of the first conveyor. The first and second stoppers can take a block position and a retracted position. The second conveyor and the first stopper operate in synchronization with an operation of the bookbinding apparatus. The second stopper takes the block position when the number of book blocks accumulated on upstream side of the first stopper exceeds a predetermined limit value, or when a thickness difference between the book blocks transported side by side exceeds a predetermined reference value.

Abstract: A composite charged particle beam apparatus includes a first charged particle beam column that irradiates a thin sample with a first charged particle beam, and a second charged particle beam column that irradiates an irradiation position of the first charged particle beam on the thin sample with a second charged particle beam. A sample holder as a base stage disposed on a sample stage, a motor-driven rotation driving section, a rotation stand rotatable about a flip axis by the driving of the rotation driving section, and a TEM grid that holds the thin sample. The TEM grid is movable within a surface perpendicular to an observation surface of the thin sample together with the rotation stand by being reciprocally driven around the flip axis by the driving section.

Abstract: A target pedestrian who is present within a range of a predetermined distance from a roadway is detected. Whether or not the target pedestrian has gazed at a crossing destination and whether or not the target pedestrian has performed a safety confirmation regarding vehicles traveling on the roadway are determined based on a gaze direction of the target pedestrian. As a result, when the target pedestrian has performed one action of either of gazing at the crossing destination and the safety confirmation, and then performed the other action within a predetermined amount of time, the target pedestrian is detected as a pre-crossing pedestrian who has an intention to cross the roadway. Consequently, a pedestrian who is attempting to cross the roadway can be accurately detected at a stage before the pedestrian actually starts crossing.

Abstract: A book block supplying machine includes a reader which reads job information from an information portion printed on a book block; and a timing adjusting portion which adjusts a supply timing at which the book block is fed toward the book binding machine. A controller includes: a job information acquisition portion which acquires the job information; an upper limit processing speed acquisition portion which acquires an upper limit processing speed; a making speed decision portion which adopts and decides the making speed; a making speed instruction portion which instructs the book binding machine to make the bound material at the making speed; a timing decision portion which decides the supply timing based on the making speed, upper limit processing speed and accumulating number; and a timing instruction portion which instructs the timing adjusting portion to supply the book block at the supply timing.

Abstract: A composite charged particle beam apparatus includes a first charged particle beam column that irradiates a thin sample with a first charged particle beam, a second charged particle beam column that irradiates an irradiation position of the first charged particle beam of the thin sample with a second charged particle beam, a sample holder that fixes the thin sample, and a sample stage on which the sample holder is mounted. The sample holder is able to rotate the thin sample within a surface parallel to an observation surface of the thin sample around a first rotational axis on the sample stage.

Abstract: A bookbinding machine calculates a rotational speed coefficient, which represents the percent change of a rotational speed of a pump 6 relative to the reference rotational speed of the pump, depending on a thickness of a book block P to be bound and a conveying speed of a clamper by use of a first function defining a relationship between the thickness of the book block and the rotational speed coefficient and a second function defining a relationship between the rotational speed coefficient and the conveying speed of the clamper, calculates the set value of the rotational speed of the pump based on the rotational speed coefficients and the reference rotational speed, and sets the rotational speed of the pump according to the set value of the rotational speed.

Abstract: A bookbinding machine calculates a rotational speed coefficient, which represents the percent change of a rotational speed of a pump 6 relative to the reference rotational speed of the pump, depending on a thickness of a book block P to be bound and a conveying speed of a clamper by use of a first function defining a relationship between the thickness of the book block and the rotational speed coefficient and a second function defining a relationship between the rotational speed coefficient and the conveying speed of the clamper, calculates the set value of the rotational speed of the pump based on the rotational speed coefficients and the reference rotational speed, and sets the rotational speed of the pump according to the set value of the rotational speed.

Abstract: A composite charged particle beam apparatus includes a first charged particle beam column that irradiates a thin sample with a first charged particle beam, a second charged particle beam column that irradiates an irradiation position of the first charged particle beam of the thin sample with a second charged particle beam, a sample holder that fixes the thin sample, and a sample stage on which the sample holder is mounted. The sample holder is able to rotate the thin sample within a surface parallel to an observation surface of the thin sample around a first rotational axis on the sample stage.

Abstract: A target pedestrian who is present within a range of a predetermined distance from a roadway is detected. Whether or not the target pedestrian has gazed at a crossing destination and whether or not the target pedestrian has performed a safety confirmation regarding vehicles traveling on the roadway are determined based on a gaze direction of the target pedestrian. As a result, when the target pedestrian has performed one action of either of gazing at the crossing destination and the safety confirmation, and then performed the other action within a predetermined amount of time, the target pedestrian is detected as a pre-crossing pedestrian who has an intention to cross the roadway. Consequently, a pedestrian who is attempting to cross the roadway can be accurately detected at a stage before the pedestrian actually starts crossing.

Abstract: A composite charged particle beam apparatus includes a first charged particle beam column that irradiates a thin sample with a first charged particle beam, a second charged particle beam column that irradiates an irradiation position of the first charged particle beam of the thin sample with a second charged particle beam, a sample holder that fixes the thin sample, and a sample stage on which the sample holder is mounted. The sample holder is able to rotate the thin sample within a surface parallel to an observation surface of the thin sample around a first rotational axis on the sample stage.

Abstract: A composite charged particle beam apparatus includes a first charged particle beam column that irradiates a thin sample with a first charged particle beam, a second charged particle beam column that irradiates an irradiation position of the first the charged particle beam of the thin sample with a second charged particle beam, and a sample holder that fixes the thin sample, and a sample stage on which the sample holder is mounted. The sample holder is able to rotate the thin sample within a surface parallel to an observation surface of the thin sample around a first rotational axis on the sample stage.

Abstract: There is provided an apparatus and a method capable of preparing a standardized probe without need for working skill of probe processing.

Abstract: Provided are a device and method capable of machining a machining target such as a sample, a probe, or a sample table without requiring a high degree of device operation skill. First, a shape generation process of determining a shape of a machining target on the basis of an ion beam scanning signal and an absorption current of the machining target is performed. Next, a machining pattern positioning process of positioning a machining pattern over an image of the machining target is performed. Further, an ion beam stopping process of stopping ion beam irradiation is performed from a result of comparison between the image of the machining target and the machining pattern while the machining target is machined through the ion beam irradiation.

Abstract: A charged particle device includes a cylindrical column (102), a charged particle beam optical system disposed in the column; a sample stage (103) disposed on the column, and a support device (211, 212) supporting the column. The support device includes a simply supported structure that simply supports the column at a plurality of support points set along an axial line direction of the column. The support points for the column are disposed at positions corresponding to the positions of nodes of vibration of the column. In this way, the rigidity of the column can be increased without increasing the weight of the column itself, whereby vibrations acting on the column can be decreased.