Patents by Inventor Shio KOMIYA

Shio KOMIYA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR LOADING AMINO ACID ON RESIN FOR SOLID-PHASE SYNTHESIS
    Publication number: 20240067674
    Abstract: An object of the present invention is to provide a method for efficiently producing a peptide compound of high purity at a high yield. It was found that an amino acid can be efficiently loaded on a resin for solid-phase synthesis by bringing an amino acid solution containing a specific solvent into contact with a resin for solid-phase synthesis that has been swollen with a specific solvent, thereby solving such problem.
    Type: Application
    Filed: December 28, 2021
    Publication date: February 29, 2024
    Inventors: Hiroko SEKITA, Shio KOMIYA, Katsunori DAN
  • DEPROTECTION METHOD AND RESIN REMOVAL METHOD IN SOLID-PHASE REACTION FOR PEPTIDE COMPOUND OR AMIDE COMPOUND, AND METHOD FOR PRODUCING PEPTIDE COMPOUND
    Publication number: 20230303619
    Abstract: The present inventors found that peptide compounds/amide compounds in which the protecting groups of interest are removed and/or which are removed from resins for solid-phase synthesis can be produced without main chain damage by contacting starting peptide compounds/amide compounds with silylating agents.
    Type: Application
    Filed: May 30, 2023
    Publication date: September 28, 2023
    Inventors: Kotaro IWASAKI, Shio KOMIYA
  • Deprotection method and resin removal method in solid-phase reaction for peptide compound or amide compound, and method for producing peptide compound
    Patent number: 11732002
    Abstract: The present inventors found that peptide compounds/amide compounds in which the protecting groups of interest are removed and/or which are removed from resins for solid-phase synthesis can be produced without main chain damage by contacting starting peptide compounds/amide compounds with silylating agents.
    Type: Grant
    Filed: November 29, 2019
    Date of Patent: August 22, 2023
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kotaro Iwasaki, Shio Komiya
  • METHOD FOR SYNTHESIZING PEPTIDE COMPOUND
    Publication number: 20230056969
    Abstract: The present inventors found that, in the synthesis of a peptide compound involving condensation of a C-terminal-activated substance of an acid component with an amine component, the C-terminal-activated substance can be removed by mixing a solution containing a residual C-terminal-activated substance after a condensation reaction with a tertiary amine and water or an aqueous solution.
    Type: Application
    Filed: December 25, 2020
    Publication date: February 23, 2023
    Inventors: Yasuhiro KONDO, Kentarou SETO, Shio KOMIYA, Zengye HOU, Masatoshi MURAKATA
  • DEPROTECTION METHOD AND RESIN REMOVAL METHOD IN SOLID-PHASE REACTION FOR PEPTIDE COMPOUND OR AMIDE COMPOUND, AND METHOD FOR PRODUCING PEPTIDE COMPOUND
    Publication number: 20220024972
    Abstract: The present inventors found that peptide compounds/amide compounds in which the protecting groups of interest are removed and/or which are removed from resins for solid-phase synthesis can be produced without main chain damage by contacting starting peptide compounds/amide compounds with silylating agents.
    Type: Application
    Filed: November 29, 2019
    Publication date: January 27, 2022
    Inventors: Kotaro IWASAKI, Shio KOMIYA