Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and comprise a capture agent for analyte detection and a substantially transparent magnetic polymer. The analog code is generated by a two-dimensional shape of a substantially non-transparent layer. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.

Abstract: A native NMOS device includes: a P-type epitaxial layer, a first and a second insulation region, a first P-type well, a second P-type well, a gate, an N-type source, and an N-type drain. The P-type epitaxial layer has a first concentration of P-type doped impurities. The first P-type well completely encompasses and is in contact with a lower surface of the N-type source. The second P-type well completely encompasses and is in contact with a lower surface of the N-type drain. Each of the first P-type well and the second P-type well has a second concentration of P-type doped impurities, and the second concentration of P-type doped impurities is higher than the first concentration of P-type doped impurities. The second concentration of P-type doped impurities is sufficient for preventing a leakage current from flowing between the N-type drain and the P-type substrate while the native NMOS device is in operation.

Abstract: A closed gas circulation system may include a sealed plenum, circulation fans, and a fan filter unit (FFU) inlet to contain, filter, condition, and re-circulate a gas through a chamber of an interface tool. The gas provided to the chamber is maintained in a conditioned environment in the closed gas circulation system as opposed to introducing external air into the chamber through the FFU inlet. This enables precise control over the relative humidity and oxygen concentration of the gas used in the chamber, which reduces the oxidation of semiconductor wafers that are transferred through the chamber. The closed gas circulation system may also include an air-flow rectifier, a return vent, and one or more vacuum pumps to form a downflow of collimated gas in the chamber and to automatically control the feed-forward pressure and flow of gas through the chamber and the sealed plenum.

Abstract: A high voltage device includes: a semiconductor layer, a well, a body region, a gate, a source, a drain, and a drift oxide region. The semiconductor layer is formed on a substrate, wherein the semiconductor layer has at least one trench. The well is formed in the semicoducotor layer. The body region is formed in the well. The gate is formed on the well, and is in contact with the well. The source and the drain are located below, outside, and at different sides of the gate, in the body region and the well respectively. The drift oxide region is formed on a drift region, wherein a bottom surface of the drift oxide region is higher than a bottom surface of the trench.

Abstract: A high voltage device includes: a semiconductor layer, a well, a body region, a gate, a source, a drain, and a drift oxide region. The semiconductor layer is formed on a substrate, wherein the semiconductor layer has at least one trench. The well is formed in the semiconductor layer. The body region is formed in the well. The gate is formed on the well, and is in contact with the well. The source and the drain are located below, outside, and at different sides of the gate, in the body region and the well respectively. The drift oxide region is formed on a drift region, wherein a bottom surface of the drift oxide region is higher than a bottom surface of the trench.

Abstract: The present invention provides a MOS (Metal-Oxide-Silicon) device having mitigated threshold voltage roll-off and a threshold voltage roll-off mitigation method therefor. The MOS device includes: a substrate, a well region, an isolation region, a gate, two LDDs (Lightly-Doped-Drains), a source, a drain and a compensation doped region. The compensation doped region is substantially in contact with at least a part of a recessed portion along the channel length direction. Viewing from a cross-section view, at a boundary where the compensation doped region is in contact with the isolation region along the channel length direction, the compensation doped region has two doped region widths along the channel width direction, wherein, the two doped region widths of the compensation doped region are both not greater than 10% of the width of the operation region. Two doped region widths are defined as distances within an interior part and an exterior part of the operation region, respectively.

Abstract: The invention relates to the use of Indoline derivatives, and their effective dose in the prevention and/or treatment of fibrosis diseases. The compound can effectively prevent and/or treat a fibrosis disease without cytotoxicity or genotoxicity.

Abstract: The present invention provides a MOS (Metal-Oxide-Silicon) device having mitigated threshold voltage roll-off and a threshold voltage roll-off mitigation method therefor. The MOS device includes: a substrate, a well region, an isolation region, a gate, two LDDs (Lightly-Doped-Drains), a source, a drain and a compensation doped region. The compensation doped region is substantially in contact with at least a part of a recessed portion along the channel length direction. Viewing from a cross-section view, at a boundary where the compensation doped region is in contact with the isolation region along the channel length direction, the compensation doped region has two doped region widths along the channel width direction, wherein, the two doped region widths of the compensation doped region are both not greater than 10% of the width of the operation region. Two doped region widths are defined as distances within an interior part and an exterior part of the operation region, respectively.

Abstract: The present invention discloses a semiconductor overlapped PN structure and manufacturing method thereof. The method includes: providing a substrate; providing a first mask to define a P (or N) type well and at least one overlapped region in the substrate; implanting P (or N) type impurities into the P (or N) type well and the at least one overlapped region; providing a second mask having at least one opening to define an N (or P) type well in the substrate, and to define at least one dual-implanted region in the at least one overlapped region; implanting N (or P) type impurities into the N (or P) type well and the at least one dual-implanted region such that the at least one dual-implanted region has P type and N type impurities.

Abstract: The present invention discloses a semiconductor overlapped PN structure and manufacturing method thereof. The method includes: providing a substrate; providing a first mask to define a P (or N) type well and at least one overlapped region in the substrate; implanting P (or N) type impurities into the P (or N) type well and the at least one overlapped region; providing a second mask having at least one opening to define an N (or P) type well in the substrate, and to define at least one dual-implanted region in the at least one overlapped region; implanting N (or P) type impurities into the N (or P) type well and the at least one dual-implanted region such that the at least one dual-implanted region has P type and N type impurities.

Abstract: The present invention discloses a semiconductor overlapped PN structure and manufacturing method thereof. The method includes: providing a substrate; providing a first mask to define a P (or N) type well and at least one overlapped region in the substrate; implanting P (or N) type impurities into the P (or N) type well and the at least one overlapped region; providing a second mask having at least one opening to define an N (or P) type well in the substrate, and to define at least one dual-implanted region in the at least one overlapped region; implanting N (or P) type impurities into the N (or P) type well and the at least one dual-implanted region such that the at least one dual-implanted region has P type and N type impurities.

Abstract: The present invention discloses a method for controlling the impurity density distribution in semiconductor device and a semiconductor device made thereby. The control method includes the steps of: providing a substrate; defining a doped area which includes at least one first region; partially masking the first region by a mask pattern; and doping impurities in the doped area to form one integrated doped region in the first region, whereby the impurity concentration of the first region is lower than a case where the first region is not masked by the mask pattern.

Abstract: An apparatus comprising a substrate of first dopant type and first dopant concentration; pocket regions in the substrate and having the first dopant type and a second dopant concentration greater than the first dopant concentration; a gate stack over the substrate and laterally between the pocket regions; first and second source/drain regions on opposing sides of the gate stack and vertically between the gate stack and the pocket regions, the first and second source/drain regions having a second dopant type opposite the first dopant type and a third dopant concentration; and third and fourth source/drain regions having the second dopant type and a fourth dopant concentration that is greater than the third dopant concentration, wherein the pocket regions are between the third and fourth source/drain regions, and the third and fourth source/drain regions are vertically between the first and second source/drain regions and a bulk portion of the substrate.

Abstract: The present invention discloses a semiconductor overlapped PN structure and manufacturing method thereof. The method includes: providing a substrate; providing a first mask to define a P (or N) type well and at least one overlapped region in the substrate; implanting P (or N) type impurities into the P (or N) type well and the at least one overlapped region; providing a second mask having at least one opening to define an N (or P) type well in the substrate, and to define at least one dual-implanted region in the at least one overlapped region; implanting N (or P) type impurities into the N (or P) type well and the at least one dual-implanted region such that the at least one dual-implanted region has P type and N type impurities.

Abstract: The present invention discloses a high voltage device and a manufacturing method thereof. The high voltage device includes: a substrate, having a P (or N) type well and an isolation structure for defining a device region; a drift region, located in the device region, having a first region and a second region wherein the first region is an N (or P) type region, and the second region is a P (or N) type region or an N (or P) type region with different dopant concentration from the first region, and from top view, the first region and the second region include sub-regions distributed in the drift region; an N (or P) type source and drain; and a gate on a surface of the substrate, between the source and drain in the device region.

Abstract: The invention provides a composition for inhibiting cancer metastasis, including: an effective amount of an amino acid hydroxamic acid derivative having a formula as shown as formula (I), formula (II) or formula (III): and a pharmaceutically acceptable carrier or salt, wherein the amino acid hydroxamic acid derivative has an effect for inhibiting cancer metastasis.

Abstract: A gated-diode semiconductor device or similar component and a method of fabricating the device. The device features a gate structure disposed on a substrate over a channel and adjacent a source and a drain. The top of the source or drain region, or both, are formed so as to be at a higher elevation, in whole or in part, than the bottom of the gate structure. This configuration may be achieved by overlaying the gate structure and substrate with a profile layer that guides a subsequent etch process to create a sloped profile. The source and drain, if both are present, may be symmetrical or asymmetrical. This configuration significantly reduces dopant encroachment and, as a consequence, reduces junction leakage.

Abstract: An organo-optoelectronic nanowire is fabricated. It is made through a one-step unit operation under a low temperature. An organo-optoelectronic template is obtained for the fabrication, whose idea is a bio-inspired one. The nanowire obtained has a high efficiency and a high surface area; and, heat generated on operation is easily emitted. Thus, the method has great potential for future use on optoelectronic devices.

Abstract: The present invention discloses a method for controlling the impurity density distribution in semiconductor device and a semiconductor device made thereby. The control method includes the steps of: providing a substrate; defining a doped area which includes at least one first region; partially masking the first region by a mask pattern; and doping impurities in the doped area to form one integrated doped region in the first region, whereby the impurity concentration of the first region is lower than a case where the first region is not masked by the mask pattern.

Abstract: A liquid crystal display (LCD) includes a bottom substrate having a top surface; a sealant located on the top surface of the bottom substrate, wherein the sealant has a pre-curing temperature; a liquid crystal mixture including a liquid crystal material and at least one reactive monomer located on the top surface of the bottom substrate and surrounded by the sealant, the at least one reactive monomer having a melting point higher than 120° C., wherein the melting point of the reactive monomer is higher than the pre-curing temperature of the sealant; at least one polymer layer polymerized from the reactive monomer, located between the bottom substrate and the liquid crystal material; and a top substrate covering the sealant and the bottom substrate to seal the liquid crystal mixture and the at least one polymer layer.