Patents by Inventor Shiping BO

Shiping BO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identifying balanced translocation break points and carrying state for balanced translocations in embryos
    Patent number: 11837325
    Abstract: Provided is a method for identifying balanced translocation breakpoints and a carrying state for balanced translocations in embryos, comprising the following steps: amplifying and sequencing a sample; comparing the sequence which is obtained by means of sequencing with a reference genome and analyzing copy numbers; accurately determining the position of a translocation breakpoint; detecting single nucleotide polymorphisms (SNPs) around the breakpoint and genotyping the SNPs; analyzing an embryonic haplotype, and comprehensively determining a normal chromosome and a translocation chromosome haplotype; determining the embryonic carrying state and, according to the haplotype, selecting an embryo which does not carry a balanced translocation.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: December 5, 2023
    Assignee: YIKON GENOMICS (SHANGHAI) CO., LTD
    Inventors: Shiping Bo, Zhen Zhang, Jun Ren, Yumei Gao, Sijia Lu
  • METHOD FOR IDENTIFYING BALANCED TRANSLOCATION BREAK POINTS AND CARRYING STATE FOR BALANCED TRANSLOCATIONS IN EMBRYOS
    Publication number: 20200010890
    Abstract: Provided is a method for identifying balanced translocation breakpoints and a carrying state for balanced translocations in embryos, comprising the following steps: amplifying and sequencing a sample; comparing the sequence which is obtained by means of sequencing with a reference genome and analyzing copy numbers; accurately determining the position of a translocation breakpoint; detecting single nucleotide polymorphisms (SNPs) around the breakpoint and genotyping the SNPs; analyzing an embryonic haplotype, and comprehensively determining a normal chromosome and a translocation chromosome haplotype; determining the embryonic carrying state and, according to the haplotype, selecting an embryo which does not carry a balanced translocation.
    Type: Application
    Filed: March 2, 2018
    Publication date: January 9, 2020
    Applicant: YIKON GENOMICS (SHANGHAI) CO., LTD
    Inventors: Shiping BO, Zhen ZHANG, Jun REN, Yumei GAO, Sijia LU