Patents by Inventor Shipra Malik

Shipra Malik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Discoidal nano universal platform for efficient delivery of PNAs
    Patent number: 11833254
    Abstract: A self-assembled discoidal PNA delivery vehicle includes a zwitterionic short chain diacyl lipid, a zwitterionic long chain diacyl lipid, a charged long chain diacyl lipid, a PEGylated lipid of the formula distearoyl phosphoethanolamine (DSPE)-PEGn-TG, and an encapsulated PNA molecule with a defined molar ratio of the zwitterionic long chain diacyl lipid and the charged long chain diacyl lipid to the short chain diacyl lipid, the molar ratio of the charged long chain diacyl lipid to the zwitterionic long chain diacyl lipid, molar % of the PEGylated lipid to all lipids, and ratio of PNA to lipid. Also described are method of self-assembling the discoidal PNA delivery vehicle and methods of enhancing cellular uptake of PNA using the discoidal PNA delivery vehicle.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: December 5, 2023
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventors: Raman Bahal, Mu-Ping Nieh, Armin Tahmasbi Rad, Shipra Malik
  • ANTI-SEED PNAS AND MICRORNA INHIBITION
    Publication number: 20230304006
    Abstract: Described herein is a modified anti-seed PNA including 5?-Xaa1Xaa2Xaa3-N1N2N3N4N5N6N7N8 N9-Xaa4-3?, wherein Xaa1, Xaa2, Xaa3, and Xaa4 are each independently R or K, wherein N1N2N3N4N5N6N7N8 N9 is a PNA which Watson-Crick base pairs to a seed sequence of an miRNA, wherein N8 and N9 may be null. Also included are methods of inhibiting expression of a miRNA in vivo or in vitro, and methods of treating cancer and other diseases and disorders with the modified anti-see PNAs.
    Type: Application
    Filed: August 17, 2021
    Publication date: September 28, 2023
    Inventors: Raman Bahal, Shipra Malik, Frank Slack
  • Discoidal Nano Universal Platform for Efficient Delivery of PNAs
    Publication number: 20210369632
    Abstract: A self-assembled discoidal PNA delivery vehicle includes a zwitterionic short chain diacyl lipid, a zwitterionic long chain diacyl lipid, a charged long chain diacyl lipid, a PEGylated lipid of the formula distearoyl phosphoethanolamine (DSPE)-PEGn-TG, and an encapsulated PNA molecule with a defined molar ratio of the zwitterionic long chain diacyl lipid and the charged long chain diacyl lipid to the short chain diacyl lipid, the molar ratio of the charged long chain diacyl lipid to the zwitterionic long chain diacyl lipid, molar % of the PEGylated lipid to all lipids, and ratio of PNA to lipid. Also described are method of self-assembling the discoidal PNA delivery vehicle and methods of enhancing cellular uptake of PNA using the discoidal PNA delivery vehicle.
    Type: Application
    Filed: May 27, 2021
    Publication date: December 2, 2021
    Inventors: Raman Bahal, Mu-Ping Nieh, Armin Tahmasbi Rad, Shipra Malik