Abstract: In an example method, a request for a dynamic access link is received from a first device. The request includes data identifying a first network resource. A subject associated with the first network resource is identified, and one or more additional network resources pertaining to the subject are determined. The dynamic access link is determined, and the dynamic access link is provided to the first device. A network resource access request is received from a second device. The network resource access request is generated responsive to the dynamic access link being selected. Responsive to receiving the network resource access request, at least one of the first resource or the one or more additional network resources is chosen, and a network address of the chosen resource is provided to the second device.

Abstract: Systems and methods for determining consensus base calls in nucleic acid sequencing are provided. A sequencing dataset is obtained corresponding to a plurality of base reads for a first base position within a plurality of base positions of a target nucleic acid molecule. The sequencing dataset includes at least two features, for each base read of the plurality of base reads. The at least two features are selected from among the features: a nucleotide base, a read quality score, a strand identifier, a trinucleotide context of the base read, and a confidence score associated with the trinucleotide context. The sequencing dataset is transformed into a feature tensor representing a distribution of the plurality of features in the sequencing dataset. The feature tensor is assessed with a classifier to determine a consensus base call for the first base position. The consensus base call comprises a predicted nucleotide base.

Abstract: In an example method, a request for a dynamic access link is received from a first device. The request includes data identifying a first network resource. A subject associated with the first network resource is identified, and one or more additional network resources pertaining to the subject are determined. The dynamic access link is determined, and the dynamic access link is provided to the first device. A network resource access request is received from a second device. The network resource access request is generated responsive to the dynamic access link being selected. Responsive to receiving the network resource access request, at least one of the first resource or the one or more additional network resources is chosen, and a network address of the chosen resource is provided to the second device.

Abstract: In an example method, a request for a dynamic access link is received from a first device. The request includes data identifying a first network resource. A subject associated with the first network resource is identified, and one or more additional network resources pertaining to the subject are determined. The dynamic access link is determined, and the dynamic access link is provided to the first device. A network resource access request is received from a second device. The network resource access request is generated responsive to the dynamic access link being selected. Responsive to receiving the network resource access request, at least one of the first resource or the one or more additional network resources is chosen, and a network address of the chosen resource is provided to the second device.

Abstract: In an example method, a request for a dynamic access link is received from a first device. The request includes data identifying a first network resource. A subject associated with the first network resource is identified, and one or more additional network resources pertaining to the subject are determined. The dynamic access link is determined, and the dynamic access link is provided to the first device. A network resource access request is received from a second device. The network resource access request is generated responsive to the dynamic access link being selected. Responsive to receiving the network resource access request, at least one of the first resource or the one or more additional network resources is chosen, and a network address of the chosen resource is provided to the second device.

Abstract: Improved methods for treating neoplastic diseases such as cancer are provided by using muteins of human tumor necrosis factor-alpha (TNF-?). Compared to wild-type human TNF-? these therapeutic TNF muteins have higher specific anti-tumor activity, but with much reduced systemic toxicity and milder side effects such chills and fever. In addition, potentially synergistic, novel combinations of the inventive TNF-? muteins with other anti-neoplastic agents are provided for effectively treating patients having particular types of cancer or malignancy or at particular stages of cancer development, and for mitigating resistance of the patients to treatment of non-TNF antineoplastic agents.