Abstract: The visual appearance of skin such as axilla skin is not improved significantly by topical application of an antiperspirant composition that is a stick that comprises at least 8% by weight of a fatty alcohol gellant. The visual appearance of a cosmetic antiperspirant composition comprising 5-30% of an astringent antiperspirant salt, 40-80% of a continuous liquid phase comprising at least one water-immiscible oil and 5-30% of a fatty alcohol wax gellant, as indicated by tone, radiance and smoothness, is enhanced by incorporating at least 0,25% of a mica pigment, optionally on the presence of a di or tri-hydric humectant and/or a triglyceride oil. Preferably the composition comprises 20 to 35% by weight of a non-volatile oil, and/or a co-gellant that melts at from 75 to 90° C. such as caster wax or polyethylene of molecular weight 300 to 600.

Abstract: The perceived visual appearance of skin such as axilla skin, as indicated by tone, radiance and/or smoothness, is improved significantly by topical application of an antiperspirant composition that is a roll-on emulsion that comprises a dihydric or trihydric humectant and/or a glyceride oil. and a mica pigment, The visual appearance can be further enhanced by incorporating into the composition a particulate microfine aluminium oxide and/or a silicone elastomer. The mica-containing compositions are advantageously applied from a roll-ball dispenser in which the depth of film of fluid on the rolling ball is controlled, such as by a spider spaced inward of the ball and/or the flow of fluid within the ball housing is perturbed such as by a castellated sealing ring and/or a shallow bead outward of the sealing ring within the ball housing.

Abstract: The invention provides the use of a compound formula (I) wherein R1 and R2 independently represent H or C1-C6 alkyl, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of: dermatological disorders; peripheral neuropathies; arthritis; gastrointestinal or urogenital disease; headache associated with substances or their withdrawal; tension headache; pediatric migraine; post-traumatic dysautonomic cephalgia; orofacial pain; allergic or chronic obstructive airways diseases, glaucoma or ocular inflammation; or prophylaxis of migraine 1

Abstract: The invention provides the use of a compound of formula (I) wherein R1 and R2 independently represent H or C1-C6 alkyl, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of dermatological disorders; peripheral neuropathies; arthritis; gastrointestinal or urogenital diseases; headache associated with substances or their withdrawal; tension headache; pediatric migraine; post-traumatic dysautonomic cephalgia; orofacial pain; allergic or chronic obstructive airways diseases; glaucoma or ocular inflammation; or prophylaxis of migraine.

Abstract: An antiperspirant composition comprising 10 to 70% by weight ethanol, a thickener in an amount up to 1%, 5 to 20% by weight of an antiperspirant active and up to 5% by weight of an emollient.