Abstract: The present invention relates to an aqueous composition comprising water, virus like particles, at least one amino group containing mucoadhesive and at least one buffer. In certain embodiments, the virus like particles have a size average of no more than about 4 times the size average of a comparison sample of virus like particles without mucoadhesive in water. In certain embodiments, the virus like particles have a size average of no more than about 400 nm. In certain embodiments, the virus like particles have a positive zeta potential.

Abstract: [Problem] To provide a physiologically active peptide-loaded stable composition for injection into living bodies. [Solution] A composition containing a triblock copolymer represented by formula (I), a polyanionic polymer and a physiologically active peptide: CNR-PEG-CNR??(I) in the formula, CNR moieties are each independently a polymer segment containing a repeating unit that contains, as a part of a pendant group, a cyclic nitroxide radical bonded to a main polymer chain via a linking group that contains at least one amino group, and PEG is a segment that contains poly(ethylene glycol).

Abstract: [Problem] To provide a physiologically active peptide-loaded stable composition for injection into living bodies. [Solution] A composition containing a triblock copolymer represented by formula (I), a polyanionic polymer and a physiologically active peptide: CNR-PEG-CNR??(I) in the formula, CNR moieties are each independently a polymer segment containing a repeating unit that contains, as a part of a pendant group, a cyclic nitroxide radical bonded to a main polymer chain via a linking group that contains at least one amino group, and PEG is a segment that contains poly(ethylene glycol).

Abstract: A orally disintegrating tablet is obtained by tableting fine granules showing controlled release of lansoprazole and an additive, which is capable of suppressing breakage of the fine granules during tableting, and can control the release of lansoprazole for a long time, and can maintain a therapeutically effective concentration for a prolonged time, and shows superior disintegration property in the oral cavity.

Abstract: A scalpel suitable for Caesarian sections and myometrium sections. The scalpel includes two sides, an edge, a back, and a curved tip. Projections and recesses are alternately formed along the edge. Sharp edges are formed on the projections or the recesses.

Abstract: A method of destroying a brittle body by molding around an elastic tube or an elastic tube in which is inserted a plastic wire or a heat-fusible member for defining a charging hole where the member or tube is partly exposed at the surface of the brittle body, and, after pulling out the elastic tube or fusing the heat-fusible member, an expandable splitting agent capable of expanding by hydration is charged into the charging hole and subjected to hydration-expansion to destroy the brittle body. In another form, a water-impermeable film enclosing an expandable splitting agent capable of expanding by hydration therein is previously buried in a brittle body in a relation partly exposed at the surface of the brittle body, and, after aperturing the exposed end of the water-impermeable film, the expandable splitting agent is subjected to hydration-expansion to destroy the brittle body.

Abstract: An expansive demolition agent prepared by crushing a clinker for manufacturing powdered expansive demolition agent obtained by sintering, which is capable of hydrating and expanding in a hole drilled in a brittle material to demolish the brittle material, the maximum particle diameter of the agent being one-third or less the diameter of the hole, and containing 10% or less of fine particles having a particle diameter of 0.3 mm or less.

Abstract: An electro-manual drawer latch for a drawer which in a manual mode locks the drawer when the drawer is pushed into a housing and unlocks the drawer when the drawer is again pushed into the housing and which in an electrical mode prevents the drawer from being manually unlocked by pushing in on the drawer but which unlocks the drawer in response to an electrical signal, the latch including a housing, a drawer slidably mounted in the housing, the drawer having a latch for locking the drawer in housing, a spring disposed between the housing and the drawer for biasing the drawer out of the housing, a locking mechanism disposed in the housing for engaging the latch when the drawer is pushed into the housing to thereby lock the drawer in the housing, the locking mechanism being operable to disengage the latch in either a manual mode in response to a manual push on the drawer or an electrical mode in which manual unlocking of the drawer is prevented and instead the drawer is unlocked in response to an electrical sig

Abstract: A compulsory switch activating latch for being fixed to the casing of a cash drawer. The latch includes a pivotable latch member for engaging a latch bar on the drawer. The pivotable latch member is also capable of limited reciprocal movement in the direction of movement of the drawer in and out of the casing. A spring between the drawer and casing urges the drawer, latch bar and pivotable latch member in the outward direction of the drawer when the latch bar is locked in the pivotable latch member. A detector is provided for detecting such movement of the movable latch member, whereby the locked condition of the pivotable latch member is detected with certainty. In the preferred embodiment, the detector includes a slidable switch member in contact with the lever of a lever microswitch, and is positioned so as to be moved by the pivotable latch member to close the microswitch when the pivotable latch member is moved outward by the spring between the drawer and casing.

Abstract: A battery driven cash drawer provided with a latching arrangement in which a solenoid energizable by a battery operates to rotate a latch lever release arm pivotally mounted to the cash drawer casing, out of engagement with an extended portion of a latch lever. The latch lever is also pivotally mounted to the casing. The release arm is connected to the latch lever through a latching spring which biases the lever and release arm into engagement. The latch lever also includes a hook shaped portion which is pivotally engageable with a drawer latch member fixed to the rear of the drawer tray. A remote switch operates to couple the solenoid to the battery. When the latch lever is engaging the latch member to hold the drawer tray in its casing, energization of the solenoid causes the release arm to rotate so as to disengage the latch lever and rotate the hook portion of the latch lever out of engagement with the drawer latch member. A drawer pushing spring then pushes the drawer tray out of the casing.

Abstract: A cash drawer includes a separate compartmented money tray which is removable therefrom. The removable money tray is compartmented both for bills and coins. The drawer includes a number of compartments in the bottom thereof and slots in the front wall of the drawer which correspond to each of the compartments. When the money tray is received in the drawer, different kinds of media such as checks, slips, or coupons can be stored in the drawer by inserting the appropriate media through a corresponding slot so that it is guided by the bottom face of the money tray into a corresponding compartment in the bottom of the drawer.

Abstract: A demolition agent which acts by means of expansive stress generated upon hydration and which is prepared by calcining limestone at 1300.degree. to 1600.degree. C. to produce a hard-burned quick lime whose crystal sizes are 10 to 100 micron, pulverizing the resulting hard-burned quick lime to 1500 to 5000 cm.sup.2 /g (Blaine), mixing 5 to 70 parts by weight of a hydraulic material to 30 to 95 parts by weight of the hard-burned quick lime and furthermore adding 0.1 to 5 parts by weight of an admixture comprising a water reducing agent to 100 parts by weight of the mixture of the powdery hard-burned quick lime and the hydraulic material.The demolition agent is used as an aqueous slurry. The slurry is filled into holes of a brittle material to demolish the brittle material by means of expansive stress generated upon hydration.

Abstract: The present demolition agent for brittle materials is prepared by pulverizing a clinker which is obtained by mixing a calcareous material, a siliceous material and gypsum at the molar ratio of CaO/SiO.sub.2 =5.0-14.4 and CaSO.sub.4 /SiO.sub.2 =0.13-1.19 and burning the mixture under an oxidizing atmosphere to 1350.degree.-1550.degree. C. The main components of the clinker thus obtained consist of 24-65% by weight of 3CaO. SiO.sub.2 crystals, 30-60% by weight of CaO crystalline particles and 5-17% by weight of CaSO.sub.4, wherein more than 50% by weight of said CaO crystalline particles is included in the large 3CaO.SiO.sub.2 crystals grown.The present demolition agent is used to break brittle materials by means of the expansive stress of aqueous slurry of the demolition agent poured into the hole of the brittle materials.

Abstract: A battery driven cash drawer provided with a latching arrangement in which a solenoid energizable by a battery operates to rotate a latch lever release arm pivotally mounted to the cash drawer casing, out of engagement with an extended portion of a latch lever. The latch lever is also pivotally mounted to the casing. The release arm is connected to the latch lever through a latching spring which biases the lever and release arm into engagement. The latch lever also includes a hook shaped portion which is pivotally engageable with a drawer latch member fixed to the rear of the drawer tray. A remote switch operates to couple the solenoid to the battery. When the latch lever is engaging the latch member to hold the drawer tray in its casing, energization of the solenoid causes the release arm to rotate so as to disengage the latch lever and rotate the hook portion of the latch lever out of engagement with the drawer latch member. A drawer pushing spring then pushes the drawer tray out of the casing.