Patents by Inventor Shiro Shirakura
Shiro Shirakura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8865731Abstract: Provided are: an agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), which comprises a compound having adenosine A2A receptor antagonistic activity or a pharmaceutically acceptable salt thereof as an active ingredient; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance or constipation; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance; and the like.Type: GrantFiled: May 29, 2009Date of Patent: October 21, 2014Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Jun Ouchi, Shunji Kunori, Yozo Kojima, Katsumi Shinoda, Katsutoshi Sasaki, Shiro Shirakura
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Publication number: 20110105465Abstract: Provided are: an agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), which comprises a compound having adenosine A2A receptor antagonistic activity or a pharmaceutically acceptable salt thereof as an active ingredient; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance or constipation; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance; and the like.Type: ApplicationFiled: May 29, 2009Publication date: May 5, 2011Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Jun Ouchi, Shunji Kunori, Yozo Kojima, Katsumi Shinoda, Katsutoshi Sasaki, Shiro Shirakura
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Patent number: 7763625Abstract: A method for treating migraine comprising administering, as an active ingredient, a xanthine derivative represented by the following formula or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 28, 2005Date of Patent: July 27, 2010Assignee: Kyowa Hakko Kirin Co., Ltd.Inventors: Megumi Takeuchi, Makoto Takayama, Shiro Shirakura, Hiroshi Kase
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Publication number: 20090181948Abstract: The present invention provides a diamine derivative or the like represented by the general formula (I): {wherein Q represents an oxygen atom or the like, RG represents a hydrogen atom or the like, RI represents (wherein p and r may be the same or different, and each represents 0 or the like, RA represents a hydrogen atom or the like, and RB and RC may be the same or different, and each represents a hydrogen atom or the like), RH represents a hydrogen atom or the like, and RJ represents: (wherein q and s may be the same or different, and each represents 0 or the like, RD represents a hydrogen atom or the like, and RE and RF may be the same or different, and each represents a hydrogen atom or the like) or the like}, etc.Type: ApplicationFiled: January 31, 2006Publication date: July 16, 2009Applicant: KYOWA HAKKO KOGYO CO., LTD.Inventors: Setsuya Sasho, Takashi Seishi, Eri Atsumi, Mariko Osakada, Ryo Hirose, Shinichiro Toki, Katsuyoshi Tsukii, Shiro Shirakura
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Patent number: 7354949Abstract: The present invention provides a therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia comprising, as an active ingredient, a tricyclic compound represented by formula (I): [wherein R1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy or halogen; X1-X2-X3 represents CR5?CR6—CR7?CR8, N(O)m?CR6—CR7?CR8, CR5?CR6—N(O)m?CR8, CR5?CR6—CR7?N(O)m, CR5?CR6—O, CR5?CR6—S, O—CR7?CR8, S—CR7?CR8 or O—CR7?N; Y represents 13 CH2S—, —CH2SO—, —CH2SO2—, —CH2O—, —CH?CH—, —(CH2)p—, —SCH2—, —SOCH2—, —SO2CH2— or —OCH2—; and R2 represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkoxy, amino, mono(substituted or unsubstituted lower alkyl)-substituted amino, di(substituted or unsubstituted lower alkyl)-substituted amino, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyType: GrantFiled: March 29, 2002Date of Patent: April 8, 2008Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tsuyoshi Yamagata, Kaoru Atsuki, Tetsuji Ohno, Shiro Shirakura, Akira Karasawa
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Patent number: 7276532Abstract: The present invention provides a therapeutic agent for overactive bladder comprising, as an active ingredient, a tricyclic compound represented by formula (I): [wherein R1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, and the like; X1—X2—X3 represents CR5?CR6—CR7?CR8, CR5?CR6—S, and the like; Y represents —CH2S—, —SOCH2—, and the like; and R2 represents a hydrogen atom, and the like] or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 29, 2002Date of Patent: October 2, 2007Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tsuyoshi Yamagata, Kaoru Atsuki, Tetsuji Ohno, Shiro Shirakura, Akira Karasawa
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Publication number: 20070185168Abstract: For example, a piperidine derivative represented by following formula (I) (wherein, —C(?O)-Z- represents —C(?O)—CH2—, —C(?O)—C(CH3)2—, —C(?O)—NH—, —C(?O)—O—, —C(?O)—S—, —C(?O)—CH2CH2—, —C(?O)—CH?CH—, —C(?O)—CH2O—, —C(?O)—CH2S—, —C(?O)—CH2CH2CH2— or —C(?O)—NR8CH2—; R1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R2 represents a hydrogen atom or hydroxy; R3 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R5 represents a hydrogen atom, hydroxy, or the like; R6 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkyl, or the like, etc.Type: ApplicationFiled: April 7, 2005Publication date: August 9, 2007Inventors: Haruki Takai, Shunji Kunori, Shiro Shirakura, Katsumi Shinoda, Atsuko Mizutani, Koji Yamada, Shinichiro Toki, Tomoyuki Nishikawa
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Publication number: 20070161663Abstract: (wherein R1, R2 and R3 are the same or different, and represent a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or a group represented by the above formula (II); and X1 and X2 are the same or different, and represent an oxygen atom or a sulfur atom) The present invention provides, for example, agents for treating migraine comprising, as an active ingredient, a xanthine derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: January 28, 2005Publication date: July 12, 2007Applicant: Kyowa Hakko Kogyo CO., Ltd.Inventors: Megumi Takeuchi, Makoto Takayama, Shiro Shirakura, Hiroshi Kase
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Publication number: 20070149555Abstract: A prophylactic and/or therapeutic agent for diseases accompanied by chronic musculoskeletal pain comprising as an active ingredient a compound having an adenosine A2A receptor antagonistic action, for example, represented by the following formula (I) (wherein R1, R2 and R3 are the same or different, each representing a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R4 represents cycloalkyl, —(CH2)n—R5 or the following formula (II); and X1 and X2 are the same or different, each representing an oxygen atom or a sulfur atom) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: March 30, 2005Publication date: June 28, 2007Applicant: Kyowa Hakko Kogyo Co., LtdInventors: Hiroshi Kase, Isami Takahashi, Shunji Kunori, Minoru Kobayashi, Shizuo Shiozaki, Shiro Shirakura
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Publication number: 20060276531Abstract: The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K+ channel opening activity as an index.Type: ApplicationFiled: August 14, 2006Publication date: December 7, 2006Applicants: KYOWA HAKKO KOGYO CO., LTD., UNIVERSITY OF PITTSBURGHInventors: Tsuyoshi Yamagata, Kaoru Atsuki, Tetsuji Ohno, Shiro Shirakura, Akira Karasawa, William de Groat, Naoki Yoshimura, Adrian Sculptoreanu
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Patent number: 7122173Abstract: The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K+ channel opening activity as an index.Type: GrantFiled: March 29, 2002Date of Patent: October 17, 2006Assignees: Kyowa Hakko Kogyo Co., Ltd., University of PittsburghInventors: Tsuyoshi Yamagata, Kaoru Atsuki, Tetsuji Ohno, Shiro Shirakura, Akira Karasawa, William C. de Groat, Naoki Yoshimura, Adrian Sculptoreanu
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Publication number: 20060160887Abstract: The present invention provides a pharmaceutical composition which is useful in the treatment for overactive bladder and the like, and comprises 3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-d ihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide or a pharmaceutically acceptable salt thereof, and an anticholinergic agent.Type: ApplicationFiled: July 16, 2004Publication date: July 20, 2006Applicant: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tsuyoshi Yamagata, Shiro Shirakura
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Publication number: 20060148885Abstract: The present invention provides a pharmaceutical composition which is useful in the treatment for bladder irritative symptoms accompanied by benign prostatic hyperplasia and the like, and comprises 3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide or a pharmaceutically acceptable salt thereof, and an ?1-adrenoceptor antagonist.Type: ApplicationFiled: July 16, 2004Publication date: July 6, 2006Applicant: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tsuyoshi Yamagata, Shiro Shirakura
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Publication number: 20040132803Abstract: The present invention provides an agent for the treatment of overactive bladder, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of overactive bladder, comprising measuring a slowly-inactivating A-type K+ channel opening activity as an index.Type: ApplicationFiled: September 30, 2003Publication date: July 8, 2004Inventors: Tsuyoshi Yamagata, Kaoru Atsuki, Tetsuji Ohno, Shiro Shirakura, Akira Karasawa, William C de Groat, Naoki Yoshimura, Adrian Sculptoreanu
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Publication number: 20040122078Abstract: The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K+ channel opening activity as an index.Type: ApplicationFiled: September 30, 2003Publication date: June 24, 2004Inventors: Tsuyoshi Yamagata, Kaoru Atsuki, Tetsuji Ohno, Shiro Shirakura, Akira Karasawa, William C de Groat, Naoki Yoshimura, Adrian Sculptoreanu
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Publication number: 20040116459Abstract: The present invention provides a therapeutic agent for overactive bladder comprising, as an active ingredient, a tricyclic compound represented by formula (I): 1Type: ApplicationFiled: September 22, 2003Publication date: June 17, 2004Inventors: Tsuyoshi Yamagata, Kaoru Atsuki, Tetsuji Ohno, Shiro Shirakura, Akira Karasawa
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Publication number: 20040106671Abstract: The present invention provides a therapeutic agent for bladder hypersensitivity comprising, as an active ingredient, a tricyclic compound represented by formula (I): 1Type: ApplicationFiled: September 22, 2003Publication date: June 3, 2004Inventors: Tsuyoshi Yamagata, Kaoru Atsuki, Tetsuji Ohno, Shiro Shirakura, Akira Karazawa
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Patent number: 5679703Abstract: Disclosed is a tricyclic compound represented by formula (I): ##STR1## where X.sup.1 -X.sup.2 represents CH.dbd.CH--CH.dbd.CH, CH.dbd.CH--CH.dbd.N or S--CH.dbd.CH;Y--Z represents CH.sub.2 --O or CH.sub.2 --S; thenL--M represents C.dbd.CR.sup.9 (in which R.sup.9 represents hydrogen or lower alkyl) or CH--CR.sup.10 R.sup.11 (in which each of R.sup.10 and R.sup.11 independently represents hydrogen or lower alkyl);W represents NR.sup.4 (in which R.sup.4 represents hydrogen or lower alkyl) or O;each of R.sup.1, R.sup.2 and R.sup.3 independently represents hydrogen, lower alkyl, lower alkoxy, halogen, nitro, amino or mono or di-lower alkyl-substituted amino;R.sup.5 represents hydrogen or lower alkyl;each of R.sup.6, R.sup.7 and R.sup.8 independently represents hydrogen, halogen, lower alkyl or lower alkoxy;provided that when Y--Z represents CH.dbd.CH or CH.sub.2 CH.sub.2, then L--M represents C.dbd.CR.sup.9 (in which R.sup.9 has the same meaning as defined above),or CH--CR.sup.10a R.sup.11a (in which each of R.sup.Type: GrantFiled: September 7, 1995Date of Patent: October 21, 1997Assignee: Kyowa Hakko Kogyo, Co., Ltd.Inventors: Masashi Yanase, Toshiaki Kumazawa, Shiro Shirakura, Eiko Oishi, Koji Yamada
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Patent number: 5478835Abstract: Disclosed is a tricyclic compound represented by the formula (I): ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, amino, C1-6 alkylamino, halogenated C1-6 alkyl, halogenated C1-6 alkoxy, halogen, nitro, cyano, carboxy, C1-6 alkoxycarbonyl, hydroxymethyl, CR.sup.9 R.sup.10 CO.sub.2 R.sup.11 (wherein each of R.sup.9, R.sup.10 and R.sup.11 independently represents hydrogen or C1-6 alkyl) or CONR.sup.12 R.sup.13 (wherein each of R.sup.12 and R.sup.13 independently represents hydrogen or C1-6-alkyl); R.sup.5 represents hydrogen or C1-6 alkyl; each of R.sup.6, R.sup.7 and R.sup.8 independently represents hydrogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkanoyloxy, C1-6 alkylthio, thiocyanato or halogen; X represents CH or N; Y.sup.1 -Y.sup.2 represents CH.sub.2 -O, CH.sub.2 -S(O).sub.n, (wherein n represents 0, 1, or 2), CH.sub.2 CH.sub.2, CH.dbd.CH or CON(R.sup.14) (wherein R.sup.Type: GrantFiled: May 2, 1994Date of Patent: December 26, 1995Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Toshiaki Kumazawa, Masashi Yanase, Hiroyuki Harakawa, Hiroyuki Obase, Shoji Oda, Shiro Shirakura, Koji Yamada, Kazuhiro Kubo
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Patent number: 5340807Abstract: Disclosed is a tricyclic compound represented by the formula (I): ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, amino, C1-6 alkylamino, halogenated C1-6 alkyl, halogenated C1-6 alkoxy, halogen, nitro, cyano, carboxy, C1-6 alkoxycarbonyl, hydroxymethyl, CR.sup.9 R.sup.10 CO.sub.2 R.sup.11 (wherein each of R.sup.9, R.sup.10 and R.sup.11 independently represents hydrogen or C1-6 alkyl) or CONR.sup.12 R.sup.13 (wherein each of R.sup.12 and R.sup.13 independently represents hydrogen or C1-6 alkyl); R.sup.5 represents hydrogen or C1-6 alkyl; each of R.sup.6, R.sup.7 and R.sup.8 independently represents hydrogen, C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkanoyloxy, C1-6 alkylthio, thiocyanato or halogen; X represents CH or N; Y.sup.1 -Y.sup.2 represents CH.sub.2 --O, CH.sub.2 --(O).sub.n, (wherein n represents 0, 1, or 2), CH.sub.2 CH.sub.2, CH.dbd.CH or CON(R.sup.14) (wherein R.sup.Type: GrantFiled: December 11, 1992Date of Patent: August 23, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Toshiaki Kumazawa, Masashi Yanase, Hiroyuki Harakawa, Hiroyuki Obase, Shoji Oda, Shiro Shirakura, Koji Yamada, Kazuhiro Kubo