Patents by Inventor Shiroh Futaki
Shiroh Futaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11179471Abstract: Provided is a peptide represented by the following formula (I): R1-IWLTALX5FLGX6X1AAX7X2X3AX8QX4LSX9L-R2?(I) wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, R1, and R2 are as defined in the specification.Type: GrantFiled: March 22, 2018Date of Patent: November 23, 2021Assignee: KYOTO UNIVERSITYInventors: Shiroh Futaki, Kentarou Sakamoto, Misao Akishiba
-
Publication number: 20200046840Abstract: Provided is a peptide represented by the following formula (I): R1-IWLTALX5FLGX6X1AAX7X2X3AX8QX4LSX9L-R2?(I) wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, R1, and R2 are as defined in the specification.Type: ApplicationFiled: March 22, 2018Publication date: February 13, 2020Applicant: KYOTO UNIVERSITYInventors: Shiroh FUTAKI, Kentarou SAKAMOTO, Misao AKISHIBA
-
Publication number: 20150202154Abstract: A lipid membrane structure for delivering a substance into a nucleus of a cell, wherein lipid membrane is modified with (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, and/or (b) a polypeptide consisting of an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1, but including deletion and/or substitution and/or insertion of one or several amino acid residues, and having an activity of promoting migration of the lipid membrane structure into a nucleus of a cell, which can efficiently deliver a nucleic acid into a nucleus of an immunocyte such as dendritic cell.Type: ApplicationFiled: February 9, 2015Publication date: July 23, 2015Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Hideyoshi HARASHIMA, Hidetaka AKITA, Mohammad Shaheen SHARIF, Takashi NAKAMURA, Soichiro ISHII, Shiroh FUTAKI
-
Patent number: 8981044Abstract: A lipid membrane structure for delivering a substance into a nucleus of a cell, wherein lipid membrane is modified with (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, and/or (b) a polypeptide consisting of an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1, but including deletion and/or substitution and/or insertion of one or several amino acid residues, and having an activity of promoting migration of the lipid membrane structure into a nucleus of a cell, which can efficiently deliver a nucleic acid into a nucleus of an immunocyte such as dendritic cell.Type: GrantFiled: April 20, 2011Date of Patent: March 17, 2015Assignee: National University Corporation Hokkaido UniversityInventors: Hideyoshi Harashima, Hidetaka Akita, Mohammad Shaheen Sharif, Takashi Nakamura, Soichiro Ishii, Shiroh Futaki
-
Patent number: 8946380Abstract: With the aim of providing a liposome, having a hydrophilic polymer introduced into the outer surface of the liposome membrane, which is a liposome capable of allowing the liposome-entrapped substance to escape from the endosome and be released into the cytoplasm, a liposome membrane component bound to the peptide shown by (a) or (b) below and a liposome membrane component bound to one end of a hydrophilic polymer the other end of which is bound to the peptide shown by (a) or (b) below are included in the liposome: (a) a peptide comprising the amino acid sequence of SEQ ID NO:1; (b) a peptide comprising the amino acid sequence of SEQ ID NO:1 with 1 or more amino acids deleted, replaced or added therein, and capable of fusing lipid membranes with one another under acidic conditions.Type: GrantFiled: January 12, 2007Date of Patent: February 3, 2015Assignee: Japan Science and Technology AgencyInventors: Kentaro Kogure, Shiroh Futaki, Hideyoshi Harashima, Shigetada Chaki
-
Patent number: 8592210Abstract: With the object of providing a liposome having cellular and nuclear entry ability, to achieve this object, a liposome is provided having on its surface a peptide comprising multiple consecutive arginine residues, and specifically a liposome is provided wherein the peptide is modified with a hydrophobic group or hydrophobic compound and the hydrophobic group or hydrophobic compound is inserted into a lipid bilayer so that the peptide is exposed on the surface of the bilayer.Type: GrantFiled: March 31, 2006Date of Patent: November 26, 2013Assignee: Japan Science and Technology AgencyInventors: Hideyoshi Harashima, Shiroh Futaki, Kentaro Kogure
-
Publication number: 20130122054Abstract: A lipid membrane structure for delivering a substance into a nucleus of a cell, wherein lipid membrane is modified with (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, and/or (b) a polypeptide consisting of an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1, but including deletion and/or substitution and/or insertion of one or several amino acid residues, and having an activity of promoting migration of the lipid membrane structure into a nucleus of a cell, which can efficiently deliver a nucleic acid into a nucleus of an immunocyte such as dendritic cell.Type: ApplicationFiled: April 20, 2011Publication date: May 16, 2013Applicant: National University Corporation Hokkaido UniversityInventors: Hideyoshi Harashima, Hidetaka Akita, Mohammad Shaheen Sharif, Takashi Nakamura, Soichiro Ishii, Shiroh Futaki
-
Publication number: 20100104623Abstract: It is intended to provide a positively charged liposome, particularly having a polyarginine peptide on a surface thereof, which is capable of increasing the resistance to a negatively charged biological component such as a protein in the blood and maintaining a high ability to deliver a substance even in the blood. An agent for enhancing the resistance of liposome against biological component comprising a peptide having at least one of the following characteristics (a) and (b) as an active ingredient: (a) A peptide comprising an amino acid sequence represented by SEQ ID No: 1 or 2; and (b) A peptide comprising an amino acid sequence represented by SEQ ID No: 1 or 2, in which one or more amino acids are deleted, substituted or added, and having an activity for promoting lipid membrane fusion under acidic condition.Type: ApplicationFiled: February 27, 2008Publication date: April 29, 2010Inventors: Hideyoshi Harashima, Kentaro Kogure, Hidetaka Akita, Akitada Iwasa, Yoshio Nakamura, Shiroh Futaki
-
Publication number: 20090305409Abstract: Disclosed is a non-viral vector capable of delivering a given substance into the nucleus of a target cell effectively even when the target cells is a undividable cell such as a dendritic cell. A bilamellar liposome having a first lipid membrane and a second lipid membrane successively from the outside, the first lipid membrane having a membrane-fusing ability and the second lipid membrane having on its surface a nuclear transport peptide.Type: ApplicationFiled: March 24, 2006Publication date: December 10, 2009Applicants: National University Corporation Hokkaido University, Kyoto University, Shionogi & Co., Ltd.Inventors: Kentaro Kogure, Takashi Nakamura, Hidetaka Akita, Hideyoshi Harashima, Shiroh Futaki
-
Publication number: 20070299244Abstract: With the aim of providing a liposome, having a hydrophilic polymer introduced into the outer surface of the liposome membrane, which is a liposome capable of allowing the liposome-entrapped substance to escape from the endosome and be released into the cytoplasm, a liposome membrane component bound to the peptide shown by (a) or (b) below and a liposome membrane component bound to one end of a hydrophilic polymer the other end of which is bound to the peptide shown by (a) or (b) below are included in the liposome: (a) a peptide comprising the amino acid sequence of SEQ ID NO:1; (b) a peptide comprising the amino acid sequence of SEQ ID NO:1 with 1 or more amino acids deleted, replaced or added therein, and capable of fusing lipid membranes with one another under acidic conditions.Type: ApplicationFiled: January 12, 2007Publication date: December 27, 2007Applicant: Japan Science and Technology AgencyInventors: Shinji Chaki, Shigetada Chaki, Kentaro Kogure, Shiroh Futaki, Hideyoshi Harashima
-
Publication number: 20070059353Abstract: With the object of providing a liposome having cellular and nuclear entry ability, to achieve this object, a liposome is provided having on its surface a peptide comprising multiple consecutive arginine residues, and specifically a liposome is provided wherein the peptide is modified with a hydrophobic group or hydrophobic compound and the hydrophobic group or hydrophobic compound is inserted into a lipid bilayer so that the peptide is exposed on the surface of the bilayer.Type: ApplicationFiled: March 31, 2006Publication date: March 15, 2007Applicant: Japan Science and Technology AgencyInventors: Hideyoshi Harashima, Shiroh Futaki, Kentaro Kogure
-
Publication number: 20060233790Abstract: The present invention provides an immunoglobulin preparation comprising an immunoglobulin-hydrophilic peptide complex in which an immunoglobulin and a hydrophilic peptide are linked optionally via a divalent group, and a pharmacologically acceptable carrier. The immunoglobulin preparation has cell permeability, or in other words, it can penetrate through a cell membrane and attain inside.Type: ApplicationFiled: March 19, 2003Publication date: October 19, 2006Inventors: Shiroh Futaki, Yukio Sugiura, Shouju Kameyama, Takeo Kikuchi