Patents by Inventor Shivaji Haribhau Shelke

Shivaji Haribhau Shelke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of sugammadex
    Patent number: 10577433
    Abstract: The present application provides an improved process for the preparation of sugammadex by reacting a salt of 3-mercapto propionic acid with 6-per-deoxy-6-per-halo-?-cyclodextrin in a suitable organic solvent. This application also provides crystalline form of a salt of 3-mercapto propionic acid, preferably di sodium salt of 3-mercapto propionic acid and its use for the preparation of sugammadex, whereas formula (I) shows the sodium salt of sugammadex.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: March 3, 2020
    Assignee: Fresenius Kabi iPSUM S.r.l.
    Inventors: Walter Cabri, Antonio Ricci, Jacopo Zanon, Saswata Lahiri, Govind Singh, Shivaji Haribhau Shelke, Tapanjyoti Biswal, Nitin Kumar, Madan Singh
  • AN IMPROVED PROCESS FOR THE PREPARATION OF SUGAMMADEX
    Publication number: 20190284308
    Abstract: The present application provides an improved process for the preparation of sugammadex by reacting a salt of 3-mercapto propionic acid with 6-per-deoxy-6-per-halo-?-cyclodextrin in a suitable organic solvent. This application also provides crystalline form of a salt of 3-mercapto propionic acid, preferably di sodium salt of 3-mercapto propionic acid and its use for the preparation of sugammadex, whereas formula (I) shows the sodium salt of sugammadex.
    Type: Application
    Filed: March 20, 2017
    Publication date: September 19, 2019
    Applicant: FRESENIUS KABI IPSUM S.R.L.
    Inventors: Walter CABRI, Antonio RICCI, Jacopo ZANON, Saswata LAHIRI, Govind SINGH, Shivaji Haribhau SHELKE, Tapanjyoti BISWAL, Nitin KUMAR, Madan SINGH
  • Crystalline forms of per-chloro-?-cyclodextrines
    Patent number: 10414830
    Abstract: The present application provides crystalline forms of 6-per-deoxy-6-per-chloro-?-cyclodextrin, and polymorphs thereof. The present application also provides methods for preparing said polymorphs by dissolving 6-per-deoxy-6-per-chloro-?-cyclodextrin in dimethylformamide and using an anti-solvent of a water/alcohol mixture.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: September 17, 2019
    Assignee: FRESENIUS KABI IPSUM S.R.L.
    Inventors: Walter Cabri, Antonio Ricci, Jacopo Zanon, Saswata Lahiri, Govind Singh, Shivaji Haribhau Shelke, Shridhar Reddy, Nitin Kumar, Madan Singh
  • CRYSTALLINE FORMS OF PER-CHLORO-GAMMA-CYCLODEXTRINES
    Publication number: 20180346608
    Abstract: The present application provides crystalline forms of 6-per-deoxy-6-per-chloro-?-cyclodextrin, and polymorphs thereof. The present application also provides methods for preparing said polymorphs by dissolving 6-per-deoxy-6-per-chloro-?-cyclodextrin in dimethylformamide and using an anti-solvent of a water/alcohol mixture.
    Type: Application
    Filed: November 24, 2016
    Publication date: December 6, 2018
    Applicant: FRESENIUS KABI IPSUM S.R.L.
    Inventors: Walter CABRI, Antonio RICCI, Jacopo ZANON, Saswata LAHIRI, Govind SINGH, Shivaji Haribhau SHELKE, Shridhar REDDY, Nitin KUMAR, Madan SINGH
  • Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
    Patent number: 8097754
    Abstract: Provided are syntheses of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin via a chiral intermediate of the following formula 4 wherein Ar is a C6-10 aromatic group, R is a straight or branched C1-4 alkyl, ester, or carboxylic acid, and R1 is a straight or branched C1-5 alkyl, aralkyl, or substituted aralkyl.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: January 17, 2012
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Vinod Kumar Kansal, Brijnath P. Chaurasia, Anand Prakash Tiwari, Shivaji Haribhau Shelke
  • Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
    Publication number: 20080306292
    Abstract: Provided are syntheses of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin via a chiral intermediate of the following formula 4 wherein Ar is a C6-10 aromatic group, R is a straight or branched C1-4 alkyl, ester, or carboxylic acid, and R1 is a straight or branched C1-5 alkyl, aralkyl, or substituted aralkyl.
    Type: Application
    Filed: March 24, 2008
    Publication date: December 11, 2008
    Inventors: Vinod Kumar Kansal, Brijnath P. Chaurasia, Anand Prakash Tiwari, Shivaji Haribhau Shelke