Patents by Inventor Shizuko Harada

Shizuko Harada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnostic reagent for hepatitis C
    Patent number: 5750331
    Abstract: A diagnostic reagent for hepatitis C, which detects an antibody induced by infection of hepatitis C virus, and comprises the second envelope protein or first non-structural protein which is encoded by the gene of hepatitis C virus and has a sugar chain. This invention also provide a method for detecting an anti-hepatitis C virus antibody. The use of the diagnostic reagent for hepatitis C according to the present invention makes highly sensitive diagnosis of hepatitis C possible.
    Type: Grant
    Filed: October 19, 1994
    Date of Patent: May 12, 1998
    Assignee: Japan as represented by Director General of Agency of National Institute of Health
    Inventors: Tatsuo Miyamura, Izumu Saito, Shizuko Harada, Yoshikazu Honda
  • Diagnostic reagent for hepatitis c
    Patent number: 5747241
    Abstract: A diagnostic reagent for hepatitis C, which detects an antibody induced by infection of hepatitis C virus, comprising the second envelope protein or first non-structural protein which is encoded by the gene of hepatitis C virus and has a sugar chain. This invention also provides a method for detecting an anti-hepatitis C virus antibody. The use of the diagnostic reagent for hepatitis C according to the present invention makes highly sensitive diagnosis of hepatitis C possible.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 5, 1998
    Assignee: Japan as represented by Director General of Agency of National Institute of Health
    Inventors: Tatsuo Miyamura, Izumu Saito, Shizuko Harada, Yoshikazu Honda
  • Hepatitis C virus antigen polypeptide, production method therefor, and antibody detection method
    Patent number: 5734019
    Abstract: A hepatitis C virus antigen polypeptide having a molecular weight of approximately 22 kilodaltons expressed from a hepatitis C virus structural gene region; a production method for a hepatitis C virus antigen polypeptide having a molecular weight of 22 kilodaltons and/or a peptide related thereto, wherein an expression vector having inserted thereinto a cDNA fragment of a hepatitis C virus structural gene region is inserted into a cultured cell line and the transfected cell line thus obtained is cultured; and a detection method for a hepatitis C virus antibody, wherein a hepatitis C virus antigen polypeptide is used as an antigen, and an antibody specific thereto is detected.
    Type: Grant
    Filed: December 11, 1992
    Date of Patent: March 31, 1998
    Assignees: National Institute of Health, Joe Chiba
    Inventors: Tatsuo Miyamura, Izumu Saito, Shizuko Harada, Yoshiharu Matsuura, Joe Chiba
  • Hepatitis C virus antigen polypeptide, production method therefor, and antibody detection method
    Patent number: 5714314
    Abstract: A hepatitis C virus antigen polypeptide having a molecular weight of approximately 22 kilodaltons expressed from a hepatitis C virus structural gene region; a production method for a hepatitis C virus antigen polypeptide having a molecular weight of 22 kilodaltons and/or a peptide related thereto, wherein an expression vector having inserted thereinto a cDNA fragment of a hepatitis C virus structural gene region is inserted into a cultured cell line and the transfected cell line thus obtained is cultured; and a detection method for a hepatitis C virus antibody, wherein a hepatitis C virus antigen polypeptide is used as an antigen, and an antibody specific thereto is detected.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: February 3, 1998
    Assignees: National Institute of Health, Joe Chiba
    Inventors: Tatsuo Miyamura, Izumu Saito, Shizuko Harada, Yoshiharu Matsuura, Joe Chiba
  • Antigenic peptide for detecting anti-hepatitis C virus antibodies and use thereof
    Patent number: 5302507
    Abstract: The antigenic peptide represented by the following amino acid sequence (SEQ ID NO: 1) ##STR1## and a method of the detection of anti-HCV antibodies wherein the above peptide is brought into contact with a sample under the conditions that the peptide is bound to anti-HCV antibodies present in the sample to form an immunological complex and the formation of the immunological complex is measured to confirm the existence of the anti HCV antibodies in the sample. The method is highly specific and sensitive to anti-HCV antibodies.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: April 12, 1994
    Assignees: Japan as represented by Director General of the Agency of the National Institute of Health, Joe Chiba
    Inventors: Joe Chiba, Tatsuo Miyamura, Izumu Saito, Shizuko Harada, Yoshiharu Matsuura