Abstract: Provided is a botulinum toxin producing method which is simple achieves a high toxin yield, and obtains a toxin having high specific activity. This botulinum toxin producing method includes: (A) a step in which a botulinum toxin is produced from botulinum toxin-producing bacteria in a medium, and a mixture a is obtained which contains a botulinum toxin, a bacterial component, and a nucleic acid component derived from the botulinum toxin; (B) a step in which the mixture a is subjected to the removal of the bacterial component, and a mixture b is obtained which contains a nucleic acid component and a botulinum toxin; (C) a step in which an endonuclease is added to the mixture b and a mixture c is obtained which contains a nucleic acid degradation product and a botulinum toxin; and (D) a step in which the mixture c is subjected to removal of the nucleic acid degradation product, and an isolated botulinum toxin liquid d is obtained.

Abstract: A vehicle bonnet structure, having designability, dent resistance and reduced weight, includes an outer panel, an inner panel attached to a back face of this outer panel, and a stiffener disposed between a front portion of the outer panel and a front portion of the inner panel and supported on the inner panel. A first step portion is provided in a vehicle-width-direction inner-side area of the outer panel which extends in the front-rear direction and has a smaller up-down dimension on the front side than on the rear side. The stiffener includes a first sealer which abuts against the outer panel in an extension line vicinity area toward the front side of a boundary portion of the first step portion and suppresses downward displacement of the outer panel, and a first bead portion extending in the front-rear direction at a position in the vicinity of the first sealer.

Abstract: A front vehicle-body structure of a vehicle ensures good vehicle appearance and ease in operating a bonnet without increasing the vehicle body weight. The front vehicle-body structure includes a bonnet including outer and inner panels, a hinge supporting the bonnet such that the bonnet can open and close, and a damper member urging the bonnet. The inner panel includes front and rear frame portions, and a pair of side frame portions respectively connecting left and right ends of the front and rear frame portions and each including a hinge mounting portion and a damper mounting portion for mounting the damper member frontward of the hinge mounting portion. The side frame portion includes a convex first bead portion formed partially in a curved shape between the hinge mounting portion and the damper mounting portion and extending back and forth from the hinge mounting portion to the damper mounting portion.

Abstract: A control device that controls a robot capable of self-propelling in a facility is provided. The control device comprises: a visitor identifying unit configured to identify a location of a visitor in the facility; a robot identifying unit configured to identify a position of the robot; an instruction unit configured to instruct the robot to capture an image of the visitor in a case where the robot is located in a predetermined range near the visitor; an estimation unit configured to estimate an emotion of the visitor, based on the image that has been captured by the robot; and a control unit configured to control whether the robot stays within the predetermined range or moves out of the predetermined range in accordance with the emotion of the visitor.

Abstract: A control device that controls a robot capable of self-propelling is provided. The control device comprises: a facility staff member identifying unit configured to identify a position of a facility staff member in a facility; a visitor identifying unit configured to identify a position of a visitor in the facility; and a control unit configured to instruct the robot capable of self-propelling to move. In a case where the control unit determines that the facility staff member that has been identified by the facility staff member identifying unit is absent in a predetermined range near the visitor that has been identified by the visitor identifying unit, the control unit causes the robot to move into the predetermined range.

Abstract: A vehicle bonnet structure, having designability, dent resistance and reduced weight, includes an outer panel, an inner panel attached to a back face of this outer panel, and a stiffener disposed between a front portion of the outer panel and a front portion of the inner panel and supported on the inner panel. A first step portion is provided in a vehicle-width-direction inner-side area of the outer panel which extends in the front-rear direction and has a smaller up-down dimension on the front side than on the rear side. The stiffener includes a first sealer which abuts against the outer panel in an extension line vicinity area toward the front side of a boundary portion of the first step portion and suppresses downward displacement of the outer panel, and a first bead portion extending in the front-rear direction at a position in the vicinity of the first sealer.

Abstract: A front vehicle-body structure of a vehicle ensures good vehicle appearance and ease in operating a bonnet without increasing the vehicle body weight. The front vehicle-body structure includes a bonnet including outer and inner panels, a hinge supporting the bonnet such that the bonnet can open and close, and a damper member urging the bonnet. The inner panel includes front and rear frame portions, and a pair of side frame portions respectively connecting left and right ends of the front and rear frame portions and each including a hinge mounting portion and a damper mounting portion for mounting the damper member frontward of the hinge mounting portion. The side frame portion includes a convex first bead portion formed partially in a curved shape between the hinge mounting portion and the damper mounting portion and extending back and forth from the hinge mounting portion to the damper mounting portion.

Abstract: In a blood purification device containing a blood purifier, a blood circuit, a blood pump, and a dialysate line having a fresh dialysate supply line and a used dialysate discharge line, a pair of plunger pumps are disposed in the dialysate line. The pair of plunger pumps are synchronized so that delivery of a fresh dialysate from one plunger pump and suction of a used dialysate into the other plunger pump simultaneously occur and the stroke of at least one of the pair of plunger pumps is made variable.

Abstract: In a blood purification device containing a blood purifier, a blood circuit, a blood pump, and a dialysate line having a fresh dialysate supply line and a used dialysate discharge line, a pair of plunger pumps are disposed in the dialysate line. The pair of plunger pumps are synchronized so that delivery of a fresh dialysate from one plunger pump and suction of a used dialysate into the other plunger pump simultaneously occur and the stroke of at least one of the pair of plunger pumps is made variable.

Abstract: It is an object of this invention to provide a stress assessment device capable of assessing mental stress without requiring another previous knowledge or imposing a load on an observer or an employee. A stress assessment device (10) of this invention includes: a work behavior acquisition unit (101) for acquiring a work behavior time-series pattern serving as information indicating a work behavior of each employee in temporal units; an eigen-behavior time-series pattern calculation unit (102) for calculating an eigen-behavior time-series pattern serving as information indicating a standard work behavior of each employee by using the work behavior time-series pattern; and a stress state assessment unit (103) for calculating a reconstruction accuracy indicating a degree to which the work behavior time-series pattern of each employee and the eigen-behavior time-series pattern agree with each other and assessing a stress state of the employee based on the calculated reconstruction accuracy.

Abstract: A constant velocity universal joint is disclosed in which the end of a track groove 24 which opens to the open end surface 26 of the outer joint member 2 is formed with a cut portion 28a, 28b for the incorporation of a ball, thereby making the incorporation of balls possible without shifting the position of the open end surface 26. Therefore, the strength of the inlet portion of the outer joint member 2 is increased. Furthermore, since the ball incorporating angle .alpha. of the cage 5 can be decreased, it is possible to increase the width of the pocket column portion 58 of the cage 5 and increase the strength of the cage 5.