Abstract: The present invention provides a method of testing the integrity of a microporous membrane using a colloid solution containing metal particles or metal compound particles that can accurately determine the integrity of a virus removal membrane formed of hydrophilized synthetic polymer that has been subjected to protein solution filtration, and to provide a method of producing the colloid solution. The colloid solution comprises a solvent and metal particles dispersed in the solvent, and the solvent comprises components (A) and (B), (A) and (C), or (A), (B), and (C), wherein the component (A) is an anionic polymer having a sulfonic acid group, the component (B) is at least one nonionic surfactant selected from the group consisting of a nonionic surfactant having a polycyclic structure in a hydrophobic moiety and a polyoxyethylene sorbitan fatty acid ester, and the component (C) is a water-soluble polymer having a pyrrolidone group.

Abstract: A colloid solution that exhibits storage stability and pH stability, being useful as viral substitute particles for use in an integrity test for virus removal membrane. In particular, a metal colloid solution characterized in that it comprises metal particles or metal compound particles of 1 to 100 nm average diameter, a water soluble high-molecular-weight dispersant having an N group and water and/or a water soluble organic solvent, the metal colloid solution being stable for a prolonged period of time and being stable in at least pH values ranging from 4 to 11.

Abstract: [Problem] An object of the present invention is to provide a method of testing the integrity of a microporous membrane using a colloid solution containing metal particles or metal compound particles that can accurately determine the integrity of a virus removal membrane formed of hydrophilized synthetic polymer that has been subjected to protein solution filtration, and to provide a method of producing the colloid solution.

Abstract: A colloid solution that exhibits storage stability and pH stability, being useful as viral substitute particles for use in an integrity test for virus removal membrane. In particular, a metal colloid solution characterized in that it comprises metal particles or metal compound particles of 1 to 100 nm average diameter, a water soluble high-molecular-weight dispersant having an N group and water and/or a water soluble organic solvent, the metal colloid solution being stable for a prolonged period of time and being stable in at least pH values ranging from 4 to 11.

Abstract: Filter membranes for efficiently eliminating pathogens such as viruses from solutions of drugs or physiologically active substances employed as starting materials thereof which are contaminated with pathogens such as viruses. These filter membranes, which can simultaneously achieve favorable performance of eliminating small viruses and a high physiologically active substance-permeability, can be obtained by controlling the membrane characteristics to give a ratio (BP/&ggr;) of the bubble point BP (MPa) to the surface tension &ggr; (N/m) of 110 or above, and/or logarithmic elimination ratios of swine parvovirus at 0 to 5 l/m2 filtration volume and at 50 to 55 l/m2, and regulating the permeability for bovine immunoglubulin, wherein the monomer content amounts to at least 80%, to 70% or more. These filter membranes make it possible to provide drugs or starting materials therefor with little fear of the contamination with viruses, etc. and, therefore, are useful in the fields of pharmacy, medicine and the like.

Abstract: In a multiple automatic packing machine comprising a slitter for slitting a wide sheet-like packing material supplied from a take-up roll into a plurality of packing films, a heat sealing device for seal molding each of the packing films into an elongated bag-like configuration by a vertical heat sealer and a lateral heat sealer, and a material filling device for filling a material to be packed into each of the packing films which has been seal molded into an elongated bag-like configuration through a feed pipe with a filling screw disposed therein which screw is rotatable by a motor, the slitting, heat sealing and material filling operations being repeatedly performed in a consecutive manner by the slitter, heat sealing device and material filling device, respectively, thereby a plurality of stick-like packing products are seal molded at a time automatically and in a consecutive manner, a packing film feeder for the multiple automatic packing machine being characterized in that the feed pipes constituting th