Abstract: LED lamp assembly comprising a safety switch, a plurality of connector pins arranged at first and second ends of the LED lamp assembly, the connector pins being adapted for electrical connection to a lamp fixture, a plurality of filament simulation circuits, wherein at least one of the connector pins at each of the first and second ends is electrically coupled to a corresponding one of the filament simulation circuits, a plurality of rectifier circuits, one or more LEDs electrically coupled to an output of the rectifier circuits, and a safety switch control circuit operatively coupled to the safety switch. At least one of the connector pins at the first end is electrically coupled via the safety switch to an input of a first one of the rectifier circuits, and at least one of the connector pins at the second end is electrically coupled to an input of a second one of the rectifier circuits.

Abstract: An LED lamp (1) for use in a luminaire (2), the LED lamp (1) comprising a plurality of LEDs (14) connected in a plurality of groups (15, 16); one or more rectifier circuits (10, 10a, 10b) adapted for rectifying an electrical current received from the luminaire (2) for supply to the LEDs (14); a first control circuit (24) adapted to estimate electrical current or electrical power received by or used by the LED lamp (1), and adapted to generate an output on the basis of the estimate; and a switching circuit (20) comprising a first switch (21) for switching the plurality of groups of LEDs (15, 16) between a plurality of different circuit configurations at a switching frequency of at least 300 kHz and according to a duty cycle; wherein the switching circuit (20) is configured to adjust the duty cycle in dependence on the output of the first control circuit (24) to adjust the electrical power used by the LED lamp (1).

Abstract: LED lamp assembly comprising a safety switch, a plurality of connector pins arranged at first and second ends of the LED lamp assembly, the connector pins being adapted for electrical connection to a lamp fixture, a plurality of filament simulation circuits, wherein at least one of the connector pins at each of the first and second ends is electrically coupled to a corresponding one of the filament simulation circuits, a plurality of rectifier circuits, one or more LEDs electrically coupled to an output of the rectifier circuits, and a safety switch control circuit operatively coupled to the safety switch. At least one of the connector pins at the first end is electrically coupled via the safety switch to an input of a first one of the rectifier circuits, and at least one of the connector pins at the second end is electrically coupled to an input of a second one of the rectifier circuits.

Abstract: The application discloses a retrofit LED lamp (16) for replacing a fluorescent lamp in fixture having a magnetic or an electronic ballast (2). The retrofit LED lamp comprises a retrofit lamp connector (1; 1?, 2; 2?) for electrically connecting the retrofit lamp (16) to the ballast (2) of the fixture. Impedances (8,9) are connected between connector points of the retrofit lamp connector (1; 1?, 2; 2?) which correspond with connector points of filaments of the fluorescent lamp replaced. Rectifying circuitry (4,5) is coupled to the retrofit lamp connector (1; 1?, 2; 2?) for rectifying an AC current received from the ballast (2) via the retrofit lamp connector (1; 1?, 2; 2?). LED circuitry (3) is coupled to the rectifying circuitry (4, 5). The Led circuitry (3) comprises LEDs for emitting light when energized by the rectified current received from the rectifying circuitry (4, 5).

Abstract: The present invention relates to small molecule 4-(piperazin-1-yl)quinazolin-2-amino compounds with formula (I) useful for inhibiting signalling by certain toll-like receptors (TLRs), especially TLR9. Toll-like receptors (TLRs) are members of the larger family of evolutionarily conserved pattern recognition receptors which are critical first line of defense for self-nonself discrimination by the host immune response. Aberrant TLR9 activation is implicated in autoreactive inflammation in different autoimmune diseases. The invention depicts compounds with formula (I), composition and methods can be used in a number of clinical applications, including as pharmaceutical agents and methods for treating conditions involving unwanted immune activity due to TLR9 activation.

Abstract: An LED lamp suitable for use in a luminaire, the LED lamp adapted for receiving electrical power from the luminaire and comprising: one or more LEDs; a ballast protection circuit including an impedance; a filter circuit; a switched-mode power supply for driving the LEDs; one or more sensing circuits for generating at least one output, in dependence on whether the electrical power received from the luminaire indicates that the electrical power is generated via a magnetic ballast, an electronic ballast which operates as a constant current ballast, an electronic ballast which operates as a constant power ballast, or not via a ballast; and a plurality of switches for defining a plurality of operation modes of the LED lamp, and for switching among the plurality of operation modes in dependence on the at least one output of the sensing circuits.

Abstract: The present invention relates to small molecule4-(piperazin-1-yl)quinazolin-2-amino compounds with formula (I) useful for inhibiting signalling by certain toll-like receptors (TLRs), especially TLR9. Toll-like receptors (TLRs) are members of the larger family of evolutionarily conserved pattern recognition receptors which are critical first line of defence for self-nonself discrimination by the host immune response. Aberrant TLR9 activation is implicated in autoreactive inflammation in different autoimmune diseases. The invention depicts compounds with formula (I), composition and methods can be used in a number of clinical applications, including as pharmaceutical agents and methods for treating conditions involving unwanted immune activity due to TLR9 activation.

Abstract: An LED lamp arrangement adapted for fitting in a luminaire. The luminaire is adapted for a fluorescent lamp and having a ballast. The LED lamp arrangement has a plurality of LEDs, and two or more electrodes for releasably connecting to the luminaire and for conducting current from the ballast for supply to the LEDs. The LED lamp arrangement further has a sensor circuit and a protection circuit. The sensor circuit and the protection circuit are adapted to increase the total load impedance of the LED lamp arrangement if the ballast is a constant power electronic ballast.

Abstract: An LED lamp arrangement for replacing a fluorescent lamp in a luminaire having a ballast. The LED lamp arrangement has at least a first group of LEDs and a second group of LEDs, a first circuit adapted to generate an output indicating whether the ballast is a magnetic ballast or a non-magnetic ballast, and a second circuit adapted to change a connection of the first and second groups of LEDs on the basis of the output of the first circuit. The second circuit is adapted to connect the first and second groups of LEDs in series, if the output from the first circuit indicates the ballast is a magnetic ballast, and to connect the first and second groups of LEDs in parallel, if the output from the first circuit indicates the ballast is a non-magnetic ballast.

Abstract: An LED lamp arrangement adapted for fitting in a luminaire. The luminaire is adapted for a fluorescent lamp and having a ballast. The LED lamp arrangement has a plurality of LEDs, and two or more electrodes for releasably connecting to the luminaire and for conducting current from the ballast for supply to the LEDs The LED lamp arrangement further has a sensor circuit and a protection circuit. The sensor circuit and the protection circuit are adapted to increase the total load impedance of the LED lamp arrangement if the ballast is a constant power electronic ballast.

Abstract: An LED lamp arrangement (1) adapted for fitting in a luminaire. The luminaire is adapted for a fluorescent lamp and having a ballast. The LED lamp arrangement has a plurality of LEDs (25, 26, 27) and two or more electrodes (22) for releasably connecting to the luminaire and for conducting current from the ballast for supply to the LEDs. The LED lamp arrangement further has a sensor circuit (21) and a protection circuit (24). The sensor circuit and the protection circuit are adapted to increase the total load impedance of the LED lamp arrangement if the ballast is a constant power electronic ballast.

Abstract: An LED lamp arrangement (1) adapted for fitting in a luminaire. The luminaire is adapted for a fluorescent lamp and having a ballast. The LED lamp arrangement has a plurality of LEDs (25, 26, 27) and two or more electrodes (22) for releasably connecting to the luminaire and for conducting current from the ballast for supply to the LEDs. The LED lamp arrangement further has a sensor circuit (21) and a protection circuit (24). The sensor circuit and the protection circuit are adapted to increase the total load impedance of the LED lamp arrangement if the ballast is a constant power electronic ballast.

Abstract: An LED lamp arrangement for replacing a fluorescent lamp in a luminaire having a ballast. The LED lamp arrangement has at least a first group of LEDs and a second group of LEDs, a first circuit adapted to generate an output indicating whether the ballast is a magnetic ballast or a non-magnetic ballast, and a second circuit adapted to change a connection of the first and second groups of LEDs on the basis of the output of the first circuit. The second circuit is adapted to connect the first and second groups of LEDs in series, if the output from the first circuit indicates the ballast is a magnetic ballast, and to connect the first and second groups of LEDs in parallel, if the output from the first circuit indicates the ballast is a non-magnetic ballast.

Abstract: An LED lamp arrangement adapted to replace a fluorescent lamp in a luminaire having a ballast for supplying power to the lamp. The LED lamp arrangement has LEDs arranged in groups. The groups of LEDs are connectable in plural circuit configurations, including at least a first circuit configuration, and a second circuit configuration having a different circuit arrangement of the groups of LEDs in which at least a portion of the groups of LEDs are connected into the circuit differently than in the first circuit configuration. The LED lamp arrangement further has a first circuit adapted to generate an output indicating whether the ballast is a magnetic ballast or a non-magnetic ballast, and a second circuit adapted to change a connection of the groups of LEDs between the first circuit configuration and the second circuit configuration on the basis of the output of the first circuit.

Abstract: An LED lamp arrangement adapted to replace a fluorescent lamp in a luminaire having a ballast for supplying power to the lamp. The LED lamp arrangement comprises a plurality of LEDs arranged in a plurality of groups, wherein the groups of LEDs are connectable in a plurality of circuit configurations, including at least a first circuit configuration, and a second circuit configuration having a different circuit arrangement of the groups of LEDs in which at least a portion of the groups of LEDs are connected into the circuit differently than in the first circuit configuration. The LED lamp arrangement further comprises a first circuit adapted to generate an output indicating whether the ballast is a magnetic ballast or a non-magnetic ballast, and a second circuit adapted to change a connection of the plurality of groups of LEDs between the first circuit configuration and the second circuit configuration on the basis of the output of the first circuit.