Abstract: A method that includes (a) receiving a training dataset, a testing dataset, a number of iterations, and a parameter space of possible parameter values that define a base model, (b) for the number of iterations, performing a parametric search process that produces a report that includes information concerning a plurality of machine learning models, where the parametric search process includes (i) generating a Bayesian optimized parameter space with an option to validate through Stratified Kfold cross validation, where an optimized parameter set includes training data from the training dataset, and testing data from the testing dataset, (ii) running the base model with the final optimized parameter set, thus yielding model results for the plurality of machine learning models, (iii) calculating Kolmogorov-Smirnov (KS) statistics for the model results, and (iv) saving the model results and the KS statistics to the report, and (c) sending the report to a user device.

Abstract: Solid films and articles having a surface with discrete regions patterned with a deposited low molecular weight organic compound, such as pharmaceutical actives and new chemical entities, are provided. The organic compound may be present at ? about 99 mass % in the one or more discrete regions and may be crystalline or amorphous. The deposited organic compound may be deposited as a film having high surface area. The deposited organic compound exhibits enhanced solubility and bioavailability, by way of non-limiting example. Methods of organic vapor jet printing deposition method of such a low molecular weight organic compound in an inert gas stream are also provided.

Abstract: In an embodiment, the present disclosure pertains to a bioreactor. In some embodiments, the bioreactor includes an inlet and an outlet, a chamber having a wall and a cell area, and a screw drive. In some embodiments, the inlet and the outlet are in fluid communication via the chamber. In a further embodiment, the present disclosure pertains to a method of modeling peristalsis. In some embodiments, the method applying at least one of axial strain, multi-axial strain, or shear stress to a wall within a bioreactor of the present disclosure, and measuring mechanical forces applied on the wall via the screw drive.

Abstract: Solid films and articles having a surface with discrete regions patterned with a deposited low molecular weight organic compound, such as pharmaceutical actives and new chemical entities, are provided. The organic compound may be present at ?about 99 mass % in the one or more discrete regions and may be crystalline or amorphous. The deposited organic compound may be deposited as a film having high surface area. The deposited organic compound exhibits enhanced solubility and bioavailability, by way of non-limiting example. Methods of organic vapor jet printing deposition method of such a low molecular weight organic compound in an inert gas stream are also provided.