Patents by Inventor Shrinivas Venkataraman
Shrinivas Venkataraman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11198761Abstract: Synthesis of polyionenes with built-in degradable linkers through addition polymerization of a novel class of degradable A2-type monomers (d-A2), and their use as antimicrobial agents are disclosed. A library of biodegradable polyionenes and Gemini-surfactants made from d-A2 monomers are also disclosed. These materials have potent and broad spectrum of antimicrobial activity with high selectivity over mammalian cells.Type: GrantFiled: February 19, 2018Date of Patent: December 14, 2021Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Yi Yan Yang, Shrinivas Venkataraman, Pang Kern Jeremy Tan
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Publication number: 20200040136Abstract: Synthesis of polyionenes with built-in degradable linkers through addition polymerization of a novel class of degradable A2-type monomers (d-A2), and their use as antimicrobial agents are disclosed. A library of biodegradable polyionenes and Gemini-surfactants made from d-A2 monomers are also disclosed. These materials have potent and broad spectrum of antimicrobial activity with high selectivity over mammalian cells.Type: ApplicationFiled: February 19, 2018Publication date: February 6, 2020Inventors: Yi Yan Yang, Shrinivas Venkataraman, Pang Kern Jeremy Tan
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Patent number: 10457772Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.Type: GrantFiled: September 8, 2017Date of Patent: October 29, 2019Assignee: International Business Machines CorporationInventors: Dylan J. Boday, Willy Chin, Jeannette M. Garcia, James L. Hedrick, Eunice Leong Jiayu, Shrinivas Venkataraman, Zhi Xiang Voo, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20190077909Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.Type: ApplicationFiled: September 8, 2017Publication date: March 14, 2019Inventors: Dylan J. BODAY, Willy CHIN, Jeannette M. GARCIA, James L. HEDRICK, Eunice Leong JIAYU, Shrinivas VENKATARAMAN, Zhi Xiang VOO, Rudy J. WOJTECKI, Yi Yan YANG
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Publication number: 20180325111Abstract: This invention relates to an antibacterial polymer-modified particle comprising a particle core, wherein a polymer is covalently bound to the particle core via a linker and said polymer comprises a branched, amphiphilic cationic polyalkylene imine backbone having amine or amino functional groups and wherein optionally all or some of the amine or amino groups of the polymer have been further reacted with amphiphilic cyclic carbonates carrying a quaternary ammonium group under formation of a urethane bond. In a preferred embodiment the core is a silica core functionalized with the polyelkyleneimine. The invention also relates to methods of making such particles and their use in water disinfection applications.Type: ApplicationFiled: October 31, 2016Publication date: November 15, 2018Inventors: Yi Yan YANG, QingXing XU, Majad KHAN, Chuan YANG, Shrinivas VENKATARAMAN
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Patent number: 9951179Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.Type: GrantFiled: February 20, 2017Date of Patent: April 24, 2018Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. Ng, Robert J. Ono, Shrinivas Venkataraman, Yi Yan Yang
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Publication number: 20170158811Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.Type: ApplicationFiled: February 20, 2017Publication date: June 8, 2017Inventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. NG, Robert J. Ono, Shrinivas Venkataraman, Yi Yan Yang
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Patent number: 9624191Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.Type: GrantFiled: September 23, 2015Date of Patent: April 18, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. Ng, Robert J. Ono, Shrinivas Venkataraman, Zhi Xiang Voo, Yi Yan Yang
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Publication number: 20160009860Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.Type: ApplicationFiled: September 23, 2015Publication date: January 14, 2016Inventors: Mareva B. Fevre, James L. Hedrick, Victor W.L. Ng, Robert J. Ono, Shrinivas Venkataraman, Zhi Xiang Voo, Yi Yan Yang
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Patent number: 9084735Abstract: Cationic, anionic, and/or zwitterionic bis-urea compounds self-assemble by non-covalent interactions in aqueous solution to form high aspect ratio nanofibers. The nanofibers reversibly bind drugs by non-covalent interactions, forming drug compositions for exhibiting sustained release of the drug.Type: GrantFiled: August 1, 2013Date of Patent: July 21, 2015Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Daniel J. Coady, Richard A. Dipietro, Amanda C. Engler, James L. Hedrick, Shao Qiong Liu, Jed W. Pitera, Shrinivas Venkataraman, Yi Yan Yang
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Publication number: 20150037390Abstract: Cationic, anionic, and/or zwitterionic bis-urea compounds self-assemble by non-covalent interactions in aqueous solution to form high aspect ratio nanofibers. The nanofibers reversibly bind drugs by non-covalent interactions, forming drug compositions for exhibiting sustained release of the drug.Type: ApplicationFiled: August 1, 2013Publication date: February 5, 2015Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Daniel J. Coady, Richard A. Dipietro, Amanda C. Engler, James L. Hedrick, Shao Qiong Liu, Hareem T. Maune, Alshakim Nelson, Jed W. Pitera, Shrinivas Venkataraman, Yi Yan Yang
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Patent number: 8926998Abstract: An antimicrobial composition comprises an anionic drug and an amine polymer comprising a first repeat unit of formula (2): wherein a? is an integer equal to 1 or 2, b? is an integer equal to 1 or 2, and each R? is an independent monovalent radical selected from the group consisting of hydrogen, methyl, ethyl, and combinations thereof. G? is a divalent linking group selected from the group consisting of a single bond and groups comprising at least one carbon. X? is a negatively charged counterion. The drug and the amine polymer are bound by noncovalent interactions.Type: GrantFiled: September 12, 2012Date of Patent: January 6, 2015Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: James L. Hedrick, Shrinivas Venkataraman, Yi Yan Yang
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Patent number: 8834861Abstract: A cyclic carbonate monomer has the formula (2): wherein i) t and t? are integers independently having a value from 0 to 6 wherein t? and t cannot both be zero, ii) each Q1 is a monovalent radical independently selected from the group consisting of hydrogen, halides, alkyl groups comprising 1 to 30 carbons, and aryl groups comprising 6 to 30 carbon atoms, iii) L? is a divalent linking group comprising one or more carbons, and iv) S? is a steroidal group.Type: GrantFiled: August 23, 2011Date of Patent: September 16, 2014Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: James Lupton Hedrick, Ashlynn Lingzhi Lee, Shrinivas Venkataraman, Yi Yan Yang
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Publication number: 20140072607Abstract: An antimicrobial composition comprises an anionic drug and an amine polymer comprising a first repeat unit of formula (2): wherein a? is an integer equal to 1 or 2, b? is an integer equal to 1 or 2, and each R? is an independent monovalent radical selected from the group consisting of hydrogen, methyl, ethyl, and combinations thereof. G? is a divalent linking group selected from the group consisting of a single bond and groups comprising at least one carbon. X? is a negatively charged counterion. The drug and the amine polymer are bound by noncovalent interactions.Type: ApplicationFiled: September 12, 2012Publication date: March 13, 2014Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: James L. Hedrick, Shrinivas Venkataraman, Yi Yan Yang
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Patent number: 8633296Abstract: A composite hydrogel comprises an amphiphilic triblock copolymer (ABA) and a loaded micelle bound by noncovalent interactions. The loaded micelle comprises a biologically active substance and an amphiphilic diblock copolymer (CD). The A blocks comprise a steroidal repeat unit (repeat unit 1) having both a backbone carbonate and a side chain bearing a steroid functional group. Each of the A blocks has a degree of polymerization of about 0.5 to about 4.0. The B block comprises a first poly(alkylene oxide) backbone. The C block comprises a second poly(alkylene oxide) backbone. The D block comprises a steroidal repeat unit (repeat unit 2) having both a backbone carbonate group and a side chain comprising a steroid functional group. The composite hydrogel is capable of controlled release of the biologically active substance.Type: GrantFiled: September 12, 2012Date of Patent: January 21, 2014Assignees: International Business Machines Corporation, Agency for Science, Technology and ResearchInventors: Daniel J. Coady, Richard A. DiPietro, Amanda C. Engler, James L. Hedrick, Ashlynn L. Lee, Shrinivas Venkataraman, Yi Yan Yang
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Publication number: 20130078283Abstract: Disclosed herein is a compound of structure (A): In this compound, X is either O or S, R1 is a rigid group, R2 is a hydrophilic group such that (A) is capable of self-assembly in water, and R3 is an organic group.Type: ApplicationFiled: January 6, 2011Publication date: March 28, 2013Inventors: Yi-Yan Yang, Shrinivas Venkataraman
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Publication number: 20120232018Abstract: A cyclic carbonate monomer has the formula (2): wherein i) t and t? are integers independently having a value from 0 to 6 wherein t? and t cannot both be zero, ii) each Q1 is a monovalent radical independently selected from the group consisting of hydrogen, halides, alkyl groups comprising 1 to 30 carbons, and aryl groups comprising 6 to 30 carbon atoms, iii) L? is a divalent linking group comprising one or more carbons, and iv) S? is a steroidal group.Type: ApplicationFiled: August 23, 2011Publication date: September 13, 2012Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: James Lupton Hedrick, Ashlynn Lingzhi Lee, Shrinivas Venkataraman, Yi Yan Yang