Patents by Inventor Shu-Bing QIAN

Shu-Bing QIAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11884685
    Abstract: A composition comprising the following structure: (1) wherein Re represents a rhenium ion having a +1 charge; (I) represents an uncharged bidentate ligand containing at least one ring containing a ring nitrogen atom bound to the rhenium (Re), and the bidentate ligand containing another nitrogen atom, either in a ring or not in a ring, bound to the rhenium (Re); and L1, L2, L3, and L4 are neutral ligands with at least one neutral ligand being an isonitrile ligand of the formula —CN—R, wherein R is an aliphatic or aromatic hydrocarbon group containing 1-20 carbon atoms; and X? represents a non-coordinating monovalent anion; wherein the bidentate ligand and R are optionally substituted by one or more groups selected from (i)-(xi) as further discussed above. Methods for treating a condition that benefits from ER stress induction, such as cancer, by administering the above rhenium complex are also disclosed.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: January 30, 2024
    Assignee: CORNELL UNIVERSITY
    Inventors: Arthur Paden King, Sierra C. Marker, Robert Swanda, Shu-Bing Qian, Justin J. Wilson
  • Publication number: 20230074066
    Abstract: Provided are compositions, methods, kits, and articles of manufacture for use in RNA sequencing. The approach is referred to as easy RNA-adenylation sequencing (“Ezra-seq”). The approach provides an alternative to 3? end linker ligation and circularization by way of an enzymatic system capable of 3? end poly(A) tailing and 5?-end adenylation for the same RNA, using two separate enzymes, or a single fusion protein. The two enzymes or the fusion protein containing them as distinct segments are a cyclase and a polymerase.
    Type: Application
    Filed: February 8, 2021
    Publication date: March 9, 2023
    Inventors: Shu-Bing QIAN, Leiming DONG, Xin SHU
  • Publication number: 20210317151
    Abstract: A composition comprising the following structure: (1) wherein Re represents a rhenium ion having a +1 charge; (I) represents an uncharged bidentate ligand containing at least one ring containing a ring nitrogen atom bound to the rhenium (Re), and the bidentate ligand containing another nitrogen atom, either in a ring or not in a ring, bound to the rhenium (Re); and L1, L2, L3, and L4 are neutral ligands with at least one neutral ligand being an isonitrile ligand of the formula —CN—R, wherein R is an aliphatic or aromatic hydrocarbon group containing 1-20 carbon atoms; and X? represents a non-coordinating monovalent anion; wherein the bidentate ligand and R are optionally substituted by one or more groups selected from (i)-(xi) as further discussed above. Methods for treating a condition that benefits from ER stress induction, such as cancer, by administering the above rhenium complex are also disclosed.
    Type: Application
    Filed: August 16, 2019
    Publication date: October 14, 2021
    Inventors: Arthur Paden KING, Sierra C. MARKER, Robert SWANDA, Shu-Bing QIAN, Justin J. WILSON